Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review

International Journal of Biological Macromolecules - Tập 150 - Trang 765-774 - 2020
Jiahui Lü1, HE Rong-jun1, Peilong Sun1, Fuming Zhang2, Robert J. Linhardt3,2,4, Anqiang Zhang1
1College of Food Science and Engineering, Zhejiang University of Technology, 310014 Hangzhou, PR China
2Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
3Department of Biomedical Engineering, Biological Science, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA

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Zeng, 2019, Effects of deproteinization methods on primary structure and antioxidant activity of Ganoderma lucidum polysaccharides, Int. J. Biol. Macromol., 126, 867, 10.1016/j.ijbiomac.2018.12.222

Hu, 2012, Evaluation of antioxidant and anti-fatigue activities of Ganoderma lucidum polysaccharides, J. Anim. Vet. Adv., 11, 4040

Bishop, 2015, From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals, Phytochemistry, 114, 56, 10.1016/j.phytochem.2015.02.015

Sohretoglu, 2018, Ganoderma lucidum polysaccharides as an anti-cancer agent, Anti-Cancer Agent. Me., 18, 667, 10.2174/1871520617666171113121246

Kladar, 2016, Ganoderma: insights into anticancer effects, Eur. J. Cancer Prev., 25, 462, 10.1097/CEJ.0000000000000204

Zhang, 2018, Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum, Int. J. Biol. Macromol. 107 (Pt A), 486, 10.1016/j.ijbiomac.2017.09.015

Chung, 2017, Ganoderma lucidum repress injury of ethanol-induced steatohepatitis via anti-inflammation, anti-oxidation and reducing hepatic lipid in C57BL/6J mice, J. Funct. Foods, 33, 314, 10.1016/j.jff.2017.03.059

Wang, 2018, Antitumor and immunomodulatory activities of Ganoderma lucidum polysaccharides in glioma-bearing rats, Integr. Cancer Ther., 17, 674, 10.1177/1534735418762537

Xiao, 2018, Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ, Food & Funct, 9, 6496, 10.1039/C8FO01656A

Li, 2019, Preparation of Ganoderma lucidum polysaccharide-chromium (III) complex and its hypoglycemic and hypolipidemic activities in high-fat and high-fructose diet-induced pre-diabetic mice, Int. J. Biol. Macromol.

Zhu, 2013, Isolation, purification, and immunological activities of a low-molecular-weight polysaccharide from the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), Int. J. of Med. Mushrooms, 15, 407, 10.1615/IntJMedMushr.v15.i4.80

Pan, 2014, Structural characterization and bioactivity evaluation of an acidic proteoglycan extract from Ganoderma lucidum fruiting bodies for PTP1B inhibition and anti-diabetes, Biopolymers, 101, 613, 10.1002/bip.22426

Huang, 2010, Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity, Int. J. Biol. Macromol., 47, 336, 10.1016/j.ijbiomac.2010.03.019

Zhao, 2010, Extraction, purification, characterization and antitumor activity of polysaccharides from Ganoderma lucidum, Carbohyd. Polym., 80, 783, 10.1016/j.carbpol.2009.12.029

Huang, 2011, Purification and structural characterization of a new water-soluble neutral polysaccharide GLP-F1-1 from Ganoderma lucidum, Int. J. Biol. Macromol., 48, 165, 10.1016/j.ijbiomac.2010.10.015

Li, 2016, Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice, Chem. Biol. Interact., 247, 30, 10.1016/j.cbi.2016.01.013

Sanchez-Martinez, 2017, Effect of beta-glucan dietary levels on immune response and hematology of channel catfish Ictalurus punctatus juveniles, Lat. Am. J. of Aquat. Res., 45, 690, 10.3856/vol45-issue4-fulltext-5

Kondakova, 2004, Structure of the neutral O-polysaccharide and biological activities of the lipopolysaccharide of Proteus mirabilis O20, Carbohydr. Res., 339, 623, 10.1016/j.carres.2003.11.016

Ye, 2009, Structural characterisation of a heteropolysaccharide by NMR spectra, Food Chem., 112, 962, 10.1016/j.foodchem.2008.07.017

Ye, 2008, Purification, NMR study and immunostimulating property of a fucogalactan from the fruiting bodies of Ganoderma lucidum, Planta Med., 74, 1730, 10.1055/s-2008-1081354

Ye, 2010, NMR characterization for polysaccharide moiety of a glycopeptide, Fitoterapia, 81, 93, 10.1016/j.fitote.2009.08.007

Kao, 2012, Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies, J. Biomed. Biotechnol., 2012, 1, 10.1155/2012/673764

Li, 2020, Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum, Int. J. Biol. Macromol., 143, 806, 10.1016/j.ijbiomac.2019.09.141

Bao, 2001, Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum, Biosci. Biotechnol. Biochem., 65, 2384, 10.1271/bbb.65.2384

Bao, 2001, Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst, Carbohydr. Res., 332, 67, 10.1016/S0008-6215(01)00075-1

Wang, 2017, Structural characterization and immuno-enhancing activity of a highly branched water-soluble beta-glucan from the spores of Ganoderma lucidum, Carbohydr. Polym., 167, 337, 10.1016/j.carbpol.2017.03.016

Li, 2007, Structure and bioactivities of a galactose rich extracellular polysaccharide from submergedly cultured Ganoderma lucidum, Carbohyd. Polym., 68, 323, 10.1016/j.carbpol.2006.12.001

Ye, 2008, Structural elucidation of the polysaccharide moiety of a glycopeptide (GLPCW-II) from Ganoderma lucidum fruiting bodies, Carbohydr. Res., 343, 746, 10.1016/j.carres.2007.12.004

Ye, 2009, Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro, Carbohyd. Polym., 77, 276, 10.1016/j.carbpol.2008.12.031

Kang, 2019, Comparison on characterization and antioxidant activity of polysaccharides from Ganoderma lucidum by ultrasound and conventional extraction, Int. J. Biol. Macromol., 124, 1137, 10.1016/j.ijbiomac.2018.11.215

Liu, 2010, Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum, Int. J. Biol. Macromol., 46, 451, 10.1016/j.ijbiomac.2010.02.006

Hung, 2008, Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, Molecules, 13, 1538, 10.3390/molecules13081538

Liu, 2014, Physicochemical characterization of a high molecular weight bioactive β-D-glucan from the fruiting bodies of Ganoderma lucidum, Carbohydr. Polym., 101, 968, 10.1016/j.carbpol.2013.10.024

Dong, 2012, A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum, Carbohydr. Res., 353, 100, 10.1016/j.carres.2012.02.029

Synytsya, 2013, Structural diversity of fungal glucans, Carbohyd. Polym., 92, 792, 10.1016/j.carbpol.2012.09.077

Zhang, 2003, Single-molecule force spectroscopy on curdlan: unwinding helical structures and random coils, Nano Lett., 3, 1119, 10.1021/nl034298d

Wu, 2019, Isolation and structural characterization of a non-competitive alpha-glucosidase inhibitory polysaccharide from the seeds of Litchi chinensis Sonn, Int. J. Biol. Macromol., 10.1016/j.ijbiomac.2019.11.170

Kulicke, 1997, Correlation between immunological activity, molar mass, and molecular structure of different (1→3)-beta-D-glucans, Carbohydr. Res., 297, 135, 10.1016/S0008-6215(96)00273-X

Yang, 2002, Chemical modification, characterization and structure-anticoagulant activity relationships of Chinese lacquer polysaccharides, Int. J. Biol. Macromol., 31, 55, 10.1016/S0141-8130(02)00066-1

Lo, 2011, Correlation evaluation of antioxidant properties on the monosaccharide components and glycosyl linkages of polysaccharide with different measuring methods, Carbohyd. Polym., 86, 320, 10.1016/j.carbpol.2011.04.056

Xu, 2009, Carboxymethylation of a polysaccharide extracted from Ganoderma lucidum enhances its antioxidant activities in vitro, Carbohyd. Polym., 78, 227, 10.1016/j.carbpol.2009.03.028

Urbinati, 2004, Chemically sulfated Escherichia coli K5 polysaccharide derivatives as extracellular HIV-1 Tat protein antagonists, FEBS Lett., 568, 171, 10.1016/j.febslet.2004.05.033

Zhang, 2012, Antitumor activity of sulfated extracellular polysaccharides of Ganoderma lucidum from the submerged fermentation broth, Carbohyd. Polym., 87, 1539, 10.1016/j.carbpol.2011.09.051

Muschin, 2011, Synthesis and specific influenza a virus-adsorptive functionality of alkyl curdlan sulfate-coated membrane filter, J. of Polym. Sci. Pol. Chem., 49, 3241, 10.1002/pola.24738

Pan, 2015, Isolation and characterization of a hyperbranched proteoglycan from Ganoderma lucidum for anti-diabetes, Carbohyd. Polym., 117, 106, 10.1016/j.carbpol.2014.09.051

Ma, 2013, Optimization for the extraction of polysaccharides from Ganoderma lucidum and their antioxidant and antiproliferative activities, J. Taiwan Inst. Chem. E., 44, 886, 10.1016/j.jtice.2013.01.032

Sui, 2016, Structure features of the intracellular polysaccharide from Ganoderma lucidum and the irrelative immune-anticancer activities of GLPs, Bio. Carbohyd. Die. Fibre, 8, 43, 10.1016/j.bcdf.2016.11.001

Xu, 2019, Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum, Int. J. Biol. Macromol., 135, 706, 10.1016/j.ijbiomac.2019.05.166

Ooi, 2002, Induction of gene expression of immunomodulatory cytokines in the mouse by a polysaccharide from Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae), Int. J. Med. Mushrooms, 4, 27, 10.1615/IntJMedMushr.v4.i1.30

Chen, 2019, Monosaccharide composition influence and immunomodulatory effects of probiotic exopolysaccharides, Int. J. Biol. Macromol., 133, 575, 10.1016/j.ijbiomac.2019.04.109

Zhang, 2016, Extraction, characterization and antioxidant activity of polysaccharides of spent mushroom compost of Ganoderma lucidum, Int. J. Biol. Macromol., 82, 432, 10.1016/j.ijbiomac.2015.10.016

Shi, 2013, Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP), Carbohyd. Polym., 95, 200, 10.1016/j.carbpol.2013.02.081

Si, 2019, Medium composition optimization, structural characterization, and antioxidant activity of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi, Int. J. Biol. Macromol., 124, 1186, 10.1016/j.ijbiomac.2018.11.274

Peng, 2015, Effects of culture conditions on monosaccharide composition of Ganoderma lucidum exopolysaccharide and on activities of related enzymes, Carbohydr. Polym., 133, 104, 10.1016/j.carbpol.2015.07.014

Chen, 2009, Modulatory effect of Ganoderma lucidum polysaccharides on serum antioxidant enzymes activities in ovarian cancer rats, Carbohyd. Polym., 78, 258, 10.1016/j.carbpol.2009.03.030

Wu, 2018, Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide, Int. J. Biol. Macromol., 118, 2001, 10.1016/j.ijbiomac.2018.07.082

Pan, 2013, Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities, Int. J. Biol. Macromol., 55, 301, 10.1016/j.ijbiomac.2013.01.022

Jia, 2009, Evaluation of in vivo antioxidant activities of Ganoderma lucidum polysaccharides in STZ-diabetic rats, Food Chem., 115, 32, 10.1016/j.foodchem.2008.11.043

Shi, 2014, Effect of ultrasonic extraction conditions on antioxidative and immunomodulatory activities of a Ganoderma lucidum polysaccharide originated from fermented soybean curd residue, Food Chem., 155, 50, 10.1016/j.foodchem.2014.01.037

Zhang, 2016, Toxicology and immunology of Ganoderma lucidum polysaccharides in Kunming mice and Wistar rats, Int. J. Biol. Macromol., 85, 302, 10.1016/j.ijbiomac.2015.12.090

Zheng, 2019, Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances, Int. J. Biol. Macromol., 121, 1240, 10.1016/j.ijbiomac.2018.10.072

Basnet, 1995, Bellidifolin stimulates glucose uptake in rat 1 fibroblasts and ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats, Planta Med., 61, 402, 10.1055/s-2006-958124

Xu, 2017, Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice, J. Funct. Foods, 38 (, 545, 10.1016/j.jff.2017.09.032

Liu, 2019, Hypoglycemic effect of inulin combined with Ganoderma lucidum polysaccharides in T2DM rats, J. Funct. Foods, 55, 381, 10.1016/j.jff.2019.02.036

Xiao, 2017, Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice, J. Ethnopharmacol., 196, 47, 10.1016/j.jep.2016.11.044

Meng, 2016, Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities, Carbohydr. Res., 424, 30, 10.1016/j.carres.2016.02.008

De Silva, 2012, Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action, Fungal Divers., 55, 1, 10.1007/s13225-012-0151-3

Feng, 2004, Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models, J. Immunol., 173, 797, 10.4049/jimmunol.173.2.797

Chan, 2009, The effects of β-glucan on human immune and cancer cells, J. Hematol. Oncol., 2, 25, 10.1186/1756-8722-2-25

Jiang, 2017, Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells, Oncol. Rep., 37, 594, 10.3892/or.2016.5246

Xu, 2011, Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities, Am. J. Chinese Med., 39, 15, 10.1142/S0192415X11008610

Cao, 2004, Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide, Acta Pharmacol. Sin., 25, 833

Stanley, 2005, Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-β1 from prostate cancer cells, Biochem. Biophy. Res. Co., 330, 46, 10.1016/j.bbrc.2005.02.116

Cao, 2006, Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell, Life Sci., 78, 1457, 10.1016/j.lfs.2005.07.017

Jin, 2017, Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats, Int. J. Biol. Macromol., 94, 1, 10.1016/j.ijbiomac.2016.09.099

Li, 2016, Effects of Ganoderma lucidum polysaccharides on chronic pancreatitis and intestinal microbiota in mice, Int. J. Biol. Macromol., 93, 904, 10.1016/j.ijbiomac.2016.09.029

Nagai, 2015, Tu1851 the potential role of polysaccharides derived from Ganoderma lucidum fungus mycelia (designated as MAK) on ameliorating indomethacin-induced small intestinal injuries through GM-CSF, Gastroenterology, 148, S, 10.1016/S0016-5085(15)33121-8

Wu, 2018, Hypolipidaemic and anti-lipidperoxidant activities of Ganoderrna lucidum polysaccharide, Int. J. Biol. Macromol., 118, 2001, 10.1016/j.ijbiomac.2018.07.082

Yang, 2010, HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression, Int. J. Biol. Macromol., 46, 167, 10.1016/j.ijbiomac.2009.11.002

Opattova, 2019, Ganoderma lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo, Mutat. Res./Gen. Tox. En., 845

Xu, 2017, Effects of Ganoderma lucidum polysaccharides against doxorubicin-induced cardiotoxicity, Biomed. Pharmacother., 95, 504, 10.1016/j.biopha.2017.08.118

Wang, 2014, Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides, Food Chem. Toxicol., 68, 183, 10.1016/j.fct.2014.03.003

Zhang, 2019, Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response, Carbohydr. Polym., 205, 192, 10.1016/j.carbpol.2018.10.028

Liu, 2015, Development of liposomal Ganoderma lucidum polysaccharide: formulation optimization and evaluation of its immunological activity, Carbohydr. Polym., 117, 510, 10.1016/j.carbpol.2014.09.093

Liu, 2016, Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response, Carbohyd. Polym., 142, 141, 10.1016/j.carbpol.2016.01.021

Yao, 2017, Ganoderma lucidum polysaccharide loaded sodium alginate micro-particles prepared via electrospraying in controlled deposition environments, Int. J. Pharm., 524, 148, 10.1016/j.ijpharm.2017.03.064

Zhang, 2019, Porous yolk-shell particle engineering via nonsolvent-assisted trineedle coaxial electrospraying for burn-related wound healing, ACS Appl. Material. Inter., 11, 7823, 10.1021/acsami.8b22112

Calvino, 2010, Ganoderma lucidum induced apoptosis in NB4 human leukemia cells: involvement of Akt and Erk, J. Ethnopharmacol., 128, 71, 10.1016/j.jep.2009.12.027