Molecular mechanism of GANT61 combined with doxorubicin in the treatment of gliomas based on network pharmacology

Electronic Journal of Biotechnology - Tập 55 - Trang 18-26 - 2022
Jing Chen1, Qiang Zhang1, Yuandong Zhuang1, Shuang Liu1, Xi Zhou1, Guoliang Zhang1
1Department of Neurosurgery, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, Fujian, China

Tài liệu tham khảo

Sun, 2019, RRM2 is a potential prognostic biomarker with functional significance in glioma, Int J Biol Sci, 15, 533, 10.7150/ijbs.30114 Huang J, Chen H, Wei Q, et al. Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma. Oncol Lett, 2017;13(3):1688–1694. https://doi.org/10.3892/ol.2017.5631. PMid: 28454310. Liu, 2016, Dual receptor recognizing cell penetrating peptide for selective targeting, efficient intratumoral diffusion and synthesized anti-glioma therapy, Theranostics, 6, 177, 10.7150/thno.13532 Joshi, 2016, Liposome size and charge optimization for intraarterial delivery to gliomas, Drug Deliv Translat Res, 6, 225, 10.1007/s13346-016-0294-y Zong, 2014, Synergistic dual-ligand doxorubicin liposomes improve targeting and therapeutic efficacy of brain glioma in animals, Mol Pharm, 11, 2346, 10.1021/mp500057n Wang, 2011, Adjuvant chemotherapy and radiotherapy in triple-negative breast carcinoma: a prospective randomized controlled multi-center trial, Radiother Oncol, 100, 200, 10.1016/j.radonc.2011.07.007 Kiyokawa, 2019, Preclinical and clinical development of oncolytic adenovirus for the treatment of malignant glioma, Oncolytic virotherapy, 8, 27, 10.2147/OV.S196403 Zhang, 2021, Application progress of network pharmacology in traditional chinese medicine research, J Nanjing Univ Tradit Chinese Med, 37, 156 Gong, 2021, Anti-aging function and molecular mechanism of Radix Astragali and Radix Astragali preparata via network pharmacology and PI3K/Akt signaling pathway, Phytomedicine, 84, 153509, 10.1016/j.phymed.2021.153509 Yuan, 2021, Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer, Life Sci, 270, 119105, 10.1016/j.lfs.2021.119105 Chaturvedi NK, Kling MJ, Coulter DW, et al. Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy. Oncotarget, 2018;9(24):16619–16633. https://doi.org/10.18632/oncotarget.24618, PMid: 29682173. Koike, 2017, Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells, Breast Cancer, 24, 683, 10.1007/s12282-017-0757-0 Geng L, Lu K, Li P, et al. GLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3. Oncotarget, 2017;8(30):48701–10. https://doi.org/10.18632/oncotarget.9792, PMid: 27275540. Li, 2018, Effect of GANT61 on the proliferation, migration, and invasion ability of Hela cells, Med J Wuhan Univ, 39, 394 Borah, 2020, GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K/Akt-mediated inhibition in breast adenocarcinoma, Nanotechnology, 31, 185102, 10.1088/1361-6528/ab6d20 Cohen, 2004, United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets, Clin Cancer Res, 10, 1212, 10.1158/1078-0432.CCR-03-0564 Massagué, 2016, Metastatic colonization by circulating tumour cells, Nature, 529, 298, 10.1038/nature17038 Chen, 2017, Cadherin switching induced by P120-catenin can promote the migration and invasion of oral squamous cell cancer cells, West China J Stomatol, 35, 183 Kalluri, 2009, The basics of epithelial-mesenchymal transition, J Clin Investig, 119, 1420, 10.1172/JCI39104 Kagaya, 2002, Abscisic acid-induced transcription is mediated by phosphorylation of an abscisic acid response element binding factor, TRAB1, Plant Cell, 14, 3177, 10.1105/tpc.005272 Ashburner, 2000, Gene ontology: tool for the unification of biology, Nat Genet, 25, 25, 10.1038/75556 Meek, 2015, Regulation of the p53 response and its relationship to cancer, Biochem J, 469, 325, 10.1042/BJ20150517 Gao S, Li D. Research advances in tumor necrosis factor and cancer. Chinese Pharmacological Bulletin, 2020;36(09):1209-1213. [Accessed: 23 March, 2021]. Available from: http://kns.cnki.net/kcms/detail/detail.aspx?FileName=YAOL202009006&DbName=CJFQ2020. Armas-López L, Zúñiga J, Arrieta O, et al. The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy. Oncotarget, 2017;8(36):60684–703. https://doi.org/10.18632/oncotarget.19527 PMid: 28948003. Han YD, Sun YX, Zhang YS, et al. High DPP4 expression predicts poor prognosis in patients with low-grade glioma. Mol Biol Rep, 2020;47(3):2189-2196. https://doi.org/10.1007/s11033-020-05321-w PMid: 32076999. He Y, Zhong W, Li Y. Progress in the diagnosis and treatment of recurrent gliomas. Hainan Med J, 2021;32(02):246-249. [Accessed: 21 March, 2021]. Available from: http://kns.cnki.net/kcms/detail/detail.aspx?FileName=HAIN202102029&DbName=CJFQ2021. Lee, 2014, Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy for diffuse large B-cell lymphoma in pregnancy may be associated with preterm birth, Obstetrics Gynecol Sci, 57, 526, 10.5468/ogs.2014.57.6.526 Xue Q, Cao L, Chen X-Y, et al. High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates. Oncol Lett, 2017;13(3):1325–1330. https://doi.org/10.3892/ol.2017.5567 PMid: 28454256. Zhang M, Li Y, Zhang Y. Expression and significance of MMP3, TIMP-1 and VEGF in glioma. Modern Med J China, 2014;16(02):20-22. [Accessed: 11 December, 2020].Available at: http://kns.cnki.net/kcms/detail/detail.aspx?FileName=ZHTY201402009&DbName=CJFQ2014. Oh, 2017, Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma, PLoS ONE, 12, e0178881, 10.1371/journal.pone.0178881 Sokolowska, 2008, Effects of PACAP and VIP on cAMP-generating system and proliferation of C6 glioma cells, J Mol Neurosci, 36, 286, 10.1007/s12031-008-9071-9 Nakagawa, 2002, Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor, during cyclic AMP-induced differentiation in rat C6 glioma cells, Mol Brain Res, 106, 12, 10.1016/S0169-328X(02)00404-7 Van Kolen, 2004, P2Y12 receptor stimulation inhibits β-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B, J Neurochem, 89, 442, 10.1111/j.1471-4159.2004.02339.x Walia MK, Ho PMW, Taylor S, et al. Activation of PTHrP-cAMP-CREB1signaling following p53 loss is essential for osteosarcoma initiation and maintenance. E life, 2016;5:e13446. https://doi.org/10.7554/eLife.13446 PMid: 27070462. Peverelli, 2017, Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells, Cancer Lett, 406, 54, 10.1016/j.canlet.2017.07.025