Molecular identification of a renal urate–anion exchanger that regulates blood urate levels

Halliwell, B. in Handbook of Antioxidants (eds Cadenas, E. & Packer, L.) 243–255 (Dekker, New York, 1996)

Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. Uric acid provides an antioxidant defence in humans against oxidant- and radical-caused aging and cancer: A hypothesis. Proc. Natl Acad. Sci. USA 78, 6858–6862 (1981)

Becker, B. F. Towards the physiological function of uric acid. Free Radical Biol. Med. 14, 615–631 (1993)

Hooper, D. C. et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl Acad. Sci. USA 95, 675–680 (1998)

Keller, J. N. et al. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18, 687–697 (1998)

Abramson, R. G. & Lipkowitz, M. S. in Basic Principles in Transport, Comparative Physiology Vol. 3 (ed. Kinne, R. K. H.) 115–153 (Karger, Basel, 1990)

Wu, X., Lee, C. C., Muzny, D. M. & Caskey, C. T. Urate oxidase: Primary structure and evolutionary implications. Proc. Natl Acad. Sci. USA 86, 9412–9416 (1989)

Wu, X., Muzny, D. M., Lee, C. C. & Caskey, C. T. Two independent mutational events in the loss of urate oxidase. J. Mol. Evol. 34, 78–84 (1992)

Maesaka, J. K. & Fishbane, S. Regulation of renal urate excretion: A critical review. Am. J. Kidney Dis. 32, 917–933 (1998)

Sica, D. A. & Schoolwerth, A. C. in The Kidney, 6th edn (ed. Brenner, B. M.) 680–700 (Saunders, Philadelphia, 2000)

Berlinger, R. W., Hilton, J. G., Yü, T. F. & Kennedy, T. J. Jr The renal mechanism for urate excretion in man. J. Clin. Invest. 29, 396–401 (1950)

Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y. & Endou, H. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272, 18526–18529 (1997)

Sweet, D. H., Wolff, N. A. & Pritchard, J. B. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J. Biol. Chem. 272, 30088–30095 (1997)

Cha, S. H. et al. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. 275, 4507–4512 (2000)

International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001)

Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M. & Koepsell, H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372, 549–552 (1994)

Koepsell, H. Organic cation transporters in intestine, kidney, liver, and brain. Annu. Rev. Physiol. 60, 243–246 (1998)

Roch-Ramel, F., Werner, D. & Guisan, B. Urate transport in brush-border membrane of human kidney. Am. J. Physiol. 266, F797–F805 (1994)

Guggino, S. E., Martin, G. J. & Aronson, P. S. Specificity and modes of the anion exchanger in dog renal microvillus membranes. Am. J. Physiol. 244, F612–F621 (1983)

Kahn, A. M., Branham, S. & Weinman, E. J. Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles. Am. J. Physiol. 245, F151–F158 (1983)

Emmerson, B. T. The management of gout. N. Engl. J. Med. 334, 445–451 (1996)

Cullem, J. H., LeVine, M. & Fiore, J. M. Studies on hyperuricemia produced by pyrazinamide. Am. J. Med. 23, 587–595 (1957)

Roch-Ramel, F., Guisan, B. & Schild, L. Indirect coupling of urate and p-aminohippurate transport to sodium in human brush-border membrane vesicles. Am. J. Physiol. 270, F61–F68 (1996)

Mandel, L. J. Metabolic substrates, cellular energy production, and the regulation of proximal tubular transport. Annu. Rev. Physiol. 47, 85–101 (1985)

Kikuchi, Y. et al. Patients with renal hypouricemia with exercise-induced acute renal failure and chronic renal dysfunction. Clin. Nephrol. 53, 467–472 (2000)

Igarashi, T., Sekine, T., Sugimura, H., Hayakawa, H. & Arayama, T. Acute renal failure after exercise in a child with renal hypouricemia. Pediatr. Nephrol. 7, 292–293 (1993)

Halabe, A. & Sperling, O. Uric acid nephrolithiasis. Miner. Electrol. Metab. 20, 424–431 (1994)

Lipkowitz, M. S. et al. Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter. J. Clin. Invest. 107, 1103–1115 (2001)

Johnson, R. J., Kivlighn, S. D., Kim, Y. G., Suga, S. & Fogo, A. B. Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease. Am. J. Kidney Dis. 33, 225–234 (1999)

Cutler, R. G. Antioxidants and aging. Am. J. Clin. Nutr. 53, 373S–379S (1991)