Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Aruffo, 1987, Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system, 84, 8573

Baenzinger, 1974, Isolation of human platelets and platelet surface membranes, Meth. Enzymol., 31, 149, 10.1016/0076-6879(74)31015-4

Bar-Shavit, 1983, Monocyte chemotaxis: stimulation by specific exosite region in thrombin, Science, 220, 728, 10.1126/science.6836310

Berndt, 1981, Platelet membrane proteins: composition and receptor function, 43

Berndt, 1985, Thrombin interactions with platelet membrane proteins, Ann. NY Acad. Sci., 485, 374, 10.1111/j.1749-6632.1986.tb34598.x

Bode, 1978, The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding, J. Mol. Biol., 118, 99, 10.1016/0022-2836(78)90246-2

Charo, 1977, Interrelations of platelet aggregation and secretion, J. Clin. Invest., 63, 866, 10.1172/JCI108841

Chen, 1975, Mitogenic activity of blood components. I. Thrombin and prothrombin, 72, 131

Chen, 1976, Mitogenicity of thrombin and surface alterations on mouse splenocytes, Exp. Cell Res., 101, 41, 10.1016/0014-4827(76)90409-2

Coleman, 1984, Translation of eukaryotic mRNA in Xenopus oocytes, 271

Dahlback, 1986, Localization of thrombin cleavage sites in the amino-terminal region of bovine protein S, J. Biol. Chem., 261, 5111, 10.1016/S0021-9258(19)89221-9

Daniel, 1986, Thrombin stimulates c-sis gene expression in microvascular endothelial cells, J. Biol. Chem., 261, 9579, 10.1016/S0021-9258(18)67551-9

Davey, 1967, Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets, Nature, 216, 857, 10.1038/216857a0

Detwiler, 1973, Kinetics of the thrombin-induced release of calcium by platelets, Biochemistry, 12, 282, 10.1021/bi00726a017

Detwiler, 1973, Kinetics of the thrombin-induced release of adenosine triphosphate by platelets, Biochemistry, 12, 2462, 10.1021/bi00737a015

Dixon, 1987, Structural features required for ligand binding to the beta-adrenergic receptor, EMBO J., 6, 3269, 10.1002/j.1460-2075.1987.tb02645.x

Dohlman, 1990, Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta2-adrenergic receptor, Biochemistry, 29, 2335, 10.1021/bi00461a018

Eidt, 1989, Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury, J. Clin. Invest., 84, 18, 10.1172/JCI114138

Fehlhammer, 1977, Crystal structure of bovine trypsinogen at 1.8A resolution, J. Mol. Biol., 111, 415, 10.1016/S0022-2836(77)80062-4

Feng, 1987, Progressive sequence alignment as a prerequisite to correct phylogenetic trees, J. Mol. Evol., 25, 351, 10.1007/BF02603120

Fraser, 1989, Site-directed mutagenesis of beta-adrenergic receptors: identification of conserved cysteine residues that independently affect ligand binding and receptor activation, J. Biol. Chem., 264, 9266, 10.1016/S0021-9258(18)60524-1

Greenberg, 1988, Characterization of a new megakaryocytic cell line: the Dami cell, Blood, 72, 1968, 10.1182/blood.V72.6.1968.1968

Gronke, 1987, Thrombin interaction with platelets: influence of a platelet protease nexin, J. Biol. Chem., 262, 3030, 10.1016/S0021-9258(18)61464-4

Grynkiewicz, 1985, A new generation of Ca2+ indicators with greatly improved fluorescence properties, J. Biol. Chem., 260, 3440, 10.1016/S0021-9258(19)83641-4

Gubler, 1983, A simple and very efficient method for generating cDNA libraries, Gene, 25, 263, 10.1016/0378-1119(83)90230-5

Hansen, 1988, Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin PPACK, 85, 3184

Hattori, 1989, Stimulated secretion of endothelial vWF is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140, J. Biol. Chem., 264, 7768, 10.1016/S0021-9258(18)83104-0

Hogg, 1978, The mechanism of the fibrinogen-thrombin relation, Thromb. Res., 12, 953, 10.1016/0049-3848(78)90051-8

Jakubowski, 1990, Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin, Blood, 75, 399, 10.1182/blood.V75.2.399.bloodjournal752399

Julius, 1988, Molecular characterization of a functional cDNA encoding the serotonin 1c receptor, Science, 241, 558, 10.1126/science.3399891

Karnik, 1988, Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin, 85, 8459

Kettner, 1979, d-Phe-pro-arg-CH2Cl: a selective affinity label for thrombin, Thromb. Res., 14, 969, 10.1016/0049-3848(79)90014-8

Krieg, 1987, In vitro RNA synthesis with SP6 RNA polymerase, Meth. Enzymol., 155, 397, 10.1016/0076-6879(87)55027-3

Kunkel, 1987, Rapid and efficient site-specific mutagenesis without phenotypic selection, Meth. Enzymol., 154, 367, 10.1016/0076-6879(87)54085-X

Kyte, 1982, A simple method for displaying the hydropathic character of a protein, J. Mol. Biol., 157, 105, 10.1016/0022-2836(82)90515-0

Lohse, 1989, Inhibition of β-adrenergic receptor kinase prevents rapid homologous desensitization of β2-adrenergic receptors, 86, 3011

Martin, 1975, Platelet stimulation by thrombin and other proteases, Biochemistry, 14, 1308, 10.1021/bi00677a032

Masu, 1987, cDNA cloning of bovine substance-K receptor through oocyte expression system, Nature, 329, 836, 10.1038/329836a0

Muszbek, 1984, Interaction of thrombin with proteins other than fibrinogen (thrombin-susceptible bonds), 83

Okamura, 1978, Platelet glycocalicin: interaction with thrombin and role as thrombin receptor on the platelet surface, J. Biol. Chem., 253, 3435, 10.1016/S0021-9258(17)34819-6

Papayannopoulou, 1987, Constitutive and inducible secretion of PDGF analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers, J. Clin. Invest., 79, 859, 10.1172/JCI112895

Paris, 1988, Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts, J. Biol. Chem., 263, 11250, 10.1016/S0021-9258(18)37949-3

Phillips, 1974, Thrombin interaction with human platelets: potentiation of thrombin-induced aggregation and release by inactivated thrombin, Thromb. Diath. Haemorrh., 32, 207

Pipili-Synetos, 1990, Expression of functional thrombin receptors in Xenopus oocytes injected with human endothelial cell mRNA, Biochem. Biophys. Res. Commun., 171, 913, 10.1016/0006-291X(90)90770-N

Rittenhouse-Simmons, 1979, Production of diglyceride from phosphatidylinositol in activated human platelets, J. Clin. Invest., 63, 580, 10.1172/JCI109339

Rydel, 1990, The structure of a complex of recombinant hirudin and human α-thrombin, Science, 249, 277, 10.1126/science.2374926

Saiki, 1988, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science, 239, 487, 10.1126/science.2448875

Sambrook, 1989

Sanger, 1977, DNA sequencing with chain-terminating inhibitors, 74, 5463

Scheraga, 1977, Active site mapping of thrombin, 145

Shuman, 1986, Thrombin-cellular interactions, Ann. NY Acad. Sci., 485, 349, 10.1111/j.1749-6632.1986.tb34585.x

Shuman, 1979, Thrombin-induced secretion: further evidence for a specific pathway, J. Clin. Invest., 63, 1211, 10.1172/JCI109416

Stenflo, 1982, Amino acid sequence of the light heavy chain of bovine protein C, J. Biol. Chem., 257, 12180, 10.1016/S0021-9258(18)33697-4

Sumikawa, 1982, The molecular cloning and characterization of cDNA coding for the alpha subunit of the acetylcholine receptor, Nucl. Acids Res., 10, 5809, 10.1093/nar/10.19.5809

Tate, 1990, Secreted alkaline phosphatase: an internal standard for expression of injected mRNAs in the Xenopus oocyte, FASEB J., 4, 227, 10.1096/fasebj.4.2.2298343

Tollefsen, 1974, The binding of thrombin to the surface of platelets, J. Biol. Chem., 249, 2646, 10.1016/S0021-9258(19)42779-8

Van Obberghen-Schilling, 1990, Functional expression of Ca2+-mobilizing alpha-thrombin receptors in mRNA-injected Xenopus oocytes, FEBS Lett., 262, 330, 10.1016/0014-5793(90)80221-4

von Heijne, 1984, How signal sequences maintain cleavage specificity, J. Mol. Biol., 173, 243, 10.1016/0022-2836(84)90192-X

Williams, 1988, Expression of receptors for cholecystokinin and other Ca2+-mobilizing hormones in Xenopus oocytes, 85, 4939

Workman, 1977, Structure-function relationships in the interaction of alpha-thrombin with blood platelets, J. Biol. Chem., 252, 7118, 10.1016/S0021-9258(19)66942-5