Molecular characterisation of a pH-gated chloride channel from Sarcoptes scabiei

Kate E. Mounsey1, Joseph A. Dent2, Deborah C. Holt1, James S. McCarthy3, Bart J. Currie4, Shelley F. Walton1
1Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia
2Department of Biology, McGill University, Montreal, Canada
3Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Australia
4Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, NT, Australia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403–410

Blackhall WJ, Pouliot JF, Prichard RK, Beech RN (1998) Haemonchus contortus: Selection at a glutamate gated chloride channel gene in ivermectin and moxidectin selected strains. Exp Parasitol 90:42–48

Blackhall WJ, Prichard RK, Beech RN (2003) Selection at a GABA receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. Mol Biochem Parasitol 131:137–145

Bloomquist JR (2003) Chloride channels as tools for developing selective insecticides. Arch Insect Biochem Physiol 54:145–156

Cary RB, Klymkowsky MW, Evans RM, Domingo A, Dent JA, Backhus LE (1994) Vimentin’s tail interacts with actin-containing structures in vivo. J Cell Sci 107:1609–1622

Cully DF, Paress PS, Liu KK, Schaeffer JM, Arena JP (1996) Identification of a Drosophila melanogaster gluatmate-gated chloride channel sensitive to the antiparasitic agent avermectin. J Biol Chem 271:20187–20191

Cully DF, Vassilatis DK, Liu KK, Paress PS, Van der Ploeg LHT, Schaeffer JM, Arena JP (1994) Cloning of an avermectin sensitive glutamate gated chloride channel from Caenorhabditis elegans. Nature 371:707–711

Currie BJ, Harumal P, McKinnon M, Walton SF (2004) First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei. Clin Infect Dis 39:e8–12

Dent JA (2006) Evidence for a diverse cys-loop ligand-gated ion channel superfamily in early bilateria. J Mol Evol 62:523–535

Dent JA, Smith MM, Vassilatis DK, Avery L (2000) The genetics of ivermectin resistance in Caenorhabditis elegans. Proc Natl Acad Sci USA 97:2674–2679

Felsenstein J (1989) PHYLIP—Phylogeny Inference Package (Version 3.2). Cladistics 5:164–166

Feng XP, Hayashi J, Beech RN, Prichard RK (2002) Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. J Neurochem 83:870–888

Ffrench-Constant RH, Mortlock DP, Shaffer CD, MacIntyre RJ, Roush RT (1991) Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. Proc Natl Acad Sci USA 88:7209–7213

Fischer K, Holt DC, Harumal P, Currie BJ, Walton SF, Kemp DJ (2003a) Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens. Am J Trop Med Hyg 68:61–64

Fischer K, Holt DC, Wilson P, Davis J, Hewitt V, Johnson M, McGrath A, Currie BJ, Walton SF, Kemp DJ (2003b) Normalization of a cDNA library cloned in lambda ZAP by a long PCR and cDNA reassociation procedure. Biotechniques 34:250–252, 254

Galzi JL, Devillers-Thiery A, Hussy N, Bertrand S, Changeux JP, Bertrand D (1992) Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359:500–505

Georgiev PG, Wolstenholme AJ, Pak WL, Semenov EP (2002) Differential responses to avermectins in ort mutants of Drosophila melanogaster. Pestic Biochem Physiol 72:65–71

Gisselmann G, Pusch H, Hovemann B, Hatt H (2002) Two cDNAs encoding for histamine-gated ion channels in D. melanogaster. Nat Neurosci 5:11–12

Goldin AL (1992) Maintenence of Xenopus laevius and Oocyte Injection. Methods Enzymol 207:266–279

Hofmann K, Stoffel W (1993) TMbase—A database of membrane spanning proteins segments. J Biol Chem 374:166

Holden-Dye L, Walker RJ (1990) Avermectin and avermectin derivatives are antagonists at the γ-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology 101 Pt 2:265–271

Holt DC, Fischer K, Allen GE, Wilson D, Wilson P, Slade R, Currie BJ, Walton SF, Kemp DJ (2003) Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei: a multigene family of inactivated serine proteases. J Invest Dermatol 121:1419–1424

Jones AK, Sattelle DB (2006) The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera. Invert Neurosci 6:123–132

Kane NS, Hirschberg B, Qian S, Hunt D, Thomas B, Brochu R, Ludmerer SW, Zheng Y, Smith M, Arena JP, Cohen CJ, Schmatz D, Warmke J, Cully DF (2000) Drug resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. Proc Natl Acad Sci USA 97:13949–13954

Lawrence G, Leafasia J, Sheridan J, Hills S, Wate J, Wate C, Montgomery J, Pandeya N, Purdie D (2005) Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin. Bull World Health Organ 83:34–42

McDonald M, Currie BJ, Carapetis JR (2004) Acute rheumatic fever: a chink in the chain that links the heart to the throat? Lancet Infect Dis 4:240–245

Mounsey KE, Holt DC, McCarthy J, Walton SF (2006) Identification of ABC transporters in Sarcoptes scabiei. Parasitology 132:883–892

Nielsen H, Krogh A (2004) Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340:783–795

Njue AI, Hayashi J, Kinne L, Feng XP, Prichard RK (2004) Mutations in the extracellular domains of glutamate gated chloride channel α3 and β subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity. J Neurochem 89:1137–1147

Pemberton DJ, Franks CJ, Walker RJ, Holden-Dye L (2001) Characterisation of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-a2 in the function of the native receptor. Mol Pharmacol 59:1037–1043

Putrenko I, Zakikhani M, Dent JA (2005) A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans. J Biol Chem 280:6392–6398

Ranganathan R, Cannon SC, Horvitz HR (2000) MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Nature 408:470–475

Roberts LJ, Huffam SE, Walton SF, Currie BJ (2005) Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect 50:375–381

Schnizler K, Saeger B, Pfeffer C, Gerbaulet A, Ebbinghaus-Kintscher U, Methfessel C, Franken EM, Raming K, Wetzel CH, Saras A, Pusch H, Hatt H, Gisselmann G (2005) A novel chloride channel in Drosophila melanogaster is inhibited by protons. J Biol Chem 280:16254–16262

Walton SF, Currie BJ (2007) Problems in diagnosing scabies, a global disease in human and animal populations. Clin Microbiol Rev 20:268–279

Wolstenholme AJ, Fairweather I, Prichard RK, von Samson-Himmelstjerna G, Sangster NC (2004) Drug resistance in veterinary helminths. Trends Parasitol 20:379–476

Zheng Y, Priest B, Cully DF, Ludmerer SW (2003) RdlDv, a novel GABA-gated chloride channel gene from the American dog tick Dermacentor variabilis. Insect Biochem Mol Biol 33:595–599