Molecular chaperones and the aging process

Alexandre CO, Camargo LM, Mattei D et al. (1997) Humoral immune response to the 72 kDa heat shock protein from Plasmodium falciparum in populations at hypoendemic areas of malaria in western Brazilian Amazon. Acta Trop 64: 155–166 Arrigo AP (1998) Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death. Biol Chem 379: 19–26 Berlett BS, Levine RL and Stadtman ER (1996) Comparison of the effects of ozone on the modification of amino acid residues in glutamine synthase and bovine serum albumin. J Biol Chem271: 4177–4182 Blake MJ, Udelsman R, Feulner GJ et al. (1991) Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response. Proc Natl Acad Sci USA 88: 9873–9877 Bonelli MA, Alfieri RR, Petronini PG et al. (1999) Attenuated expression of 70-kDa heat shock protein in WI-38 human fibroblasts during aging in vitro. Exp Cell Res 252: 20–32 Buchner J (1999) Hsp90 & co.-a holding for folding. Trends Biochem Sci 24: 136–141 Bukau B and Horwich AL (1998) The Hsp70 and Hsp60 chaperone machines. Cell 92: 351–366 Cherian Mand Abraham EC (1995) Decreased molecular chaperone property of alpha-crystallins due to posttranslational modifications. Biochem Biophys Res Commun 208: 675–679 Choi HS, Lin Z, Li BS et al. (1990) Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts. J Biol Chem 265: 18005–18011 Cisse S, Perry G, Lacoste-Royal G et al. (1993) Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains. Acta Neuropathol Berl 85: 233–240 Conconi M, Szweda LI, Levine RL et al. (1996) Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat shock protein 90. Arch Biochem Biophys331: 232–240 Cristofalo VJ, Doggett DL, Brooks-Frederich KM et al. (1998) Growth factors as probes of cell aging. Exp Gerontol 24: 367–374 Csermely P (1997) Proteins, RNA-s, chaperones and enzyme evolution: a folding perspective. Trends Biochem Sci 22: 147–149 Csermely, P (1999) The 'chaperone-percolator' model: a possible molecular mechanism of Anfinsen-cage type chaperone action. BioEssays 21: 959–965 Csermely P, Schnaider T, Soti Cs et al. (1998) The 90 kDa molecular chaperone family: structure, function and clinical applications. A comprehensive review. Pharmacol Therapeutics 79: 129–168 Demchenko AP, Orlovska NN and Sukhomudrenko AG (1983) Agedependent changes of protein structure. The properties of young and old rabbit aldolase are restored after reversible denaturation. Exp Gerontol 18: 437–446 Deguchi Y, Negoro S and Kishimoto S (1988) Age-related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells. Biochem Biophys Res Commun 157: 580–584 Derham BK and Harding JJ (1997) Effect of aging on the chaperone-like function of human alpha-crystallin assessed by three methods. Biochem J 328: 763–768 Derham BK and Harding JJ (1999) Alpha-crystallin as a molecular chaperone. Progr Retinal Eye Res 18: 463–509 Duprat F, Guillemare E, Romey G et al. (1995) Susceptibility of cloned KC channels to reactive oxygen species. Proc Natl Acad Sci USA 92: 11796–11800 Effros RB, Zhu X and Walford RL (1994) Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J Gerontol 49: B65-B70 Ehrenfried JA, Evers BM, Chu KU et al. (1996) Caloric restriction increases the expression of heat shock protein in the gut. Ann Surg 223: 592–599 Faassen AE, O'Leary JJ, Rodysill KJ et al. (1989) Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes form aged donors. Exp Cell Res 183: 326–334 Fargnoli J, Kunisada T, Fornace AJ Jr et al. (1990) Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci USA 87: 846–850 Faulds G, Conroy S, Madaio M et al. (1995) Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mplpr/ lpr mice. Br J Rheumatol 34: 610–615 Fleming JE, Walton JK, Dubitsky R et al. (1988) Aging results in an unusual expression of Drosophila heat shock proteins. Proc Natl Acad Sci USA 85: 4099–4103 Friguet B, Stadtman ER and Szweda LI (1994) Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease. J Biol Chem 269: 21639–21643 Gabai VL, Meriin AB, Yaglom JA et al. (1998) Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 438: 1–4 Getchell TV, Krishna NS, Dhooper N et al. Human olfactory receptor neurons express heat shock protein 70: age-related trends. Ann Otho Rhinol Laryngol 104: 47–56 Guttsmann-Conrad A, Heydari AR, You S et al. (1998) The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects. Exp Cell Res 241: 404–413 Hamos JE, Oblas B, Pulaski-Salo D et al. (1991) Expression of heat shock proteins in Alzheimer's disease. Neurology 41: 345–350 Harding JJ, Beswick HT, Ajiboye R et al. (1989) Non-enzymatic post-translational modification of proteins in aging. A review. Mech Aging Dev 50: 7–16 Hartl F-U (1996) Molecular chaperones in cellular protein folding. Nature 381: 571–580 Heydari AR, Wu B, Takahashi R et al. (1993) Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Mol Cell Biol 13: 2909–2918 Heydari AR, Takahashi R, Gutsmann A et al. (1994) Hsp70 and aging. Experientia 50: 1092–1098 Holt SE, Aisner DL, Baur J et al. (1999) Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 13: 817–826 Kamei A, Iwase H and Masuda K (1997) Cleavage of amino acid residue(s) from the N-terminal region of alpha A-, and alpha B-crystallins in human crystalline lens during aging. Biochem Biophys Res Commun 231: 373–378 Khazaeli AA, Tatar M, Pletcher SD et al. (1997) Heat-induced longevity extension in Drosophila. 1. Heat treatment, mortality, and thermotolerance. J Gerontol A 52: B48-B52 Kimura Y, Sakai T, Takeuchi M et al. (1996) An unique CD4CCD8C intestinal lymphocyte specific for DnaK (Escherichia coli Hsp70) may be selected by intestinal microflora of rats. Immunobiology 196: 550–556 Krawczyk Z and Szymik N (1989) Effect of age and busulphan treatment of the hsp70 gene-related transcript level in rat testes. Int J Androl 12: 72–79 Kregel KC and Moseley PL (1996) Differential effects of exercise and heat stress on liver hsp70 accumulation with aging. J Appl Physiol 80: 547–551 Lin P, Smith DL and Smith JB (1997) In vivo modification of the C-terminal lysine of human lens alphaB-crystallin. Exp Eye Res 65: 673–680 Lithgow GJ and Kirkwood TBL (1996) Mechanisms and evolution of aging. Science 273: 80 Lithgow GJ, White T, Melov S et al. (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92: 7540–7544 Liu AY-C, Lin Z, Choi H-S et al. (1989) Attenuated induction of heat shock gene expression in aging diploid fibroblasts. J Biol Chem 264: 12037–12045 Liu AY-C, Lee Y-K, Manalo D et al. (1996) Attenuated heat shock transcriptional response in aging: molecular mechanism and implication in the biology of aging. In: Feige U, Morimoto RI, Yahara I et al. (eds) Stress Inducible Cellular Responses. EXS Vol 77, pp 393–408. Birkhauser Verlag, Basel Locke M and Tanguay RM (1996) Diminished heat shock response in the aged myocardium. Cell Stress and Chaperones 1: 251–260 Maiello M, Boeri D, Sampietro L et al. (1998) Basal synthesis of heat shock protein 70 increases with age in rat kidneys. Gerontology 44: 15–20 Marchalonis JJ, Schluter SF, Wilson L et al. (1993) Natural human antibodies to synthetic peptide autoantigens: correlation with age and autoimmune disease. Gerontology 39: 65–79 Miyaishi O, Ito Y, Kozaki K et al. (1995) Age-related attenuation of Hsp47 heat response in fibroblasts. Mech Ageing Dev 77: 213–226 Monnier VMand Cerami A (1981) Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science 211: 491–493 Moore SA, Lopez A, Richardson A et al. (1998) Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages. Mech Ageing Dev 104: 59–73 Morimoto RI (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12: 3788–3796 Nakanishi Y and Yasumoto K (1997) Induction after administering paraquat of heme oxigenase-1 and heat shock protein in the liver of senescence-accelerated mice. Biosci Biotechnol Biochem 61: 1302–1306 Niedzwiecki A, Kongpachith AM and Fleming JE (1991) Aging affects expression of 70-kDa heat shock proteins in Drosophila. J Biol Chem 266: 9332–9338 Niedzwiecki A, Reveillaud I and Fleming JE (1992) Changing in superoxide dismutase and catalase in aging heat-shocked Drosophila. Free Radic Res Commun 17: 355–367 Nitta Y, Abe K, Aoki M et al. (1994) Diminished heat shock protein 70 mRNA induction in aged rat hearts after ischemia. Am J Physiol 267: H1795-H1803 Pahlavani MA, Harris MD, Moore SA et al. (1995) The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys. Exp Cell Res 218: 310–318 Pahlavani MA, Harris MD, Moore SA et al. (1996) Expression of heat shock protein 70 in rat spleen lymphocytes is affected by age but not by food restriction. J Nutr 126: 2069–2075 Perez N, Sugar J, Charya S et al. (1991) Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Brain Res Mol Brain Res 11: 249–254 Piotrowicz RS, Weber LA, Hickey E et al. (1995) Accelerated growth and senescence of arterial cells expressing the small molecular weight heat-shock protein Hsp27. FASEB J 9: 1079–1084 Portig I, Pankuweit S and Maisch B (1997) Antibodies against stress proteins in sera of patients with dilated cardiomyopathy. J Mol Cell Cardiol 29: 2245–2251 Pratt WB (1997) The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. Annu Rev Pharmacol Toxicol 37: 297–326 PrattWB and Toft DO (1997) Steroid receptor interactions with heat shock protein and immunophilin complexes. Endocrine Rev 18: 306–360 Rao DV, Watson K and Jones GL (1999) Age-related attenuation in the expression of the major heat shock proteins in human peripheral lymphocytes. Mech Ageing Dev 107: 105–118 Razzaque MS, Shimokawa I, Nazneen A et al. (1998) Age-related nephropathy in the Fischer 344 rat is associated with overexpression of collagens and collagen-binding heat shock protein 47. Cell Tissue Res 293: 471–478 Reiss U and Rothstein M (1974) Heat-labile isozymes of isocitrate lyase from aging Turbatrix aceti. Biochem Biophys Res Commun 61: 1012–1016 Renkawek K, Bosman GJ and Gaestel M (1993) Increased expression of heat-shock protein 27 kDa in Alzheimer disease: a preliminary study. Neuroreport 5: 14–16 Rutherford SL and Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396: 336–342 Schauerte JA and Gafni A (1995) Photodegradation of tryptophan residues and attenuation of molecular chaperone activity in alpha-crystallin are correlated. Biochem Biophys Res Commun 212: 900–905 Schirmer EC, Glover JR, Singer MA et al. (1996) HSP100/Clp proteins: a common mechanism explains diverse functions. Trends Biochem Sci 21: 289–296 Schliwa M, van Blerkom J and Porter KR (1981) Stabilization of the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc Natl Acad Sci USA 78: 4329–4333 Serrano M, Lin AW, McCurrah ME et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593–602 Shama S, Lai CY, Antoniazzi JM et al. (1998) Heat stress-induced life span extension in yeast. Exp Cell Res 245: 379–388 Sharma KK and Ortwerth BJ (1995) Effect of cross-linking on the chaperone-like function of alpha crystallin. Exp Eye Res 61: 413–421 Shepherd JC, Walldorf U, Hug P et al. (1989) Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Proc Natl Acad Sci USA 86: 7520–7521 Shikama N, Ackermann R and Brack C (1994) Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster. Proc Natl Acad Sci USA 91: 4199–4203 Shinohara H, Inaguma Y, Goto S et al. (1993) Alpha B crystallin and Hsp28 are enhanced in the cerebral cortex of patients with Alzheimer's disease. J Neurol Sci 119: 203–208 Smith JB, Jiang X and Abraham EC (1997) Identification of hydrogen peroxide oxidation sites of alpha A-and alpha B-crystallins. Free Radic Res 26: 103–111 Smith JR and Pereira-Smith OM (1996) Replicative senescence: implications for in vivo aging and tumor suppression. Science 273: 63–67 Sohal RS and Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273: 59–63 Stadtman ER (1992) Protein oxidation and aging. Science 257: 1220–1224 Sun J, Kale SP, Childress AM et al. (1994) Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269: 18638–18645 Sun H, Gao J, Ferrington DA et al. (1999) Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase. Biochemistry 38: 105–112 Tatar M, Khazaeli AA and Curtsinger JW (1997) Chaperoning extended life. Nature 390: 30 Voorter CEM, de Haard-Hoekman WA, van den Oetelaar PJM et al. (1988) Spontaneous peptide bond cleavage in aging _-crystallin through a succinimide intermediate. J Biol Chem 263: 19020–19023 Wadhwa R, Kaul SC, Ikawa Y et al. (1993a) Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. J Biol Chem 268: 6615–6621 Wadhwa R, Kaul SC, Sugimoto Y et al. (1993b) Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells. J Biol Chem 268: 22239–22242 Wakutani Y, Urakami K, Shimomura T et al. (1995) Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the Alzheimer type. Dementia 6: 301–305 Wheeler JC, Bieschke ET and Tower J (1995) Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress. Proc Natl Acad Sci USA 92: 10408–10412 Wolosewick JJ and Porter KR (1979) Microtrabecular lattice of the cytoplasmic ground substance. Artifact or reality. J Cell Biol 82: 114–139 Wright HT (1991) Nonenzymatic deamination of asparaginyl and glutaminyl residues in proteins. Crit Rev Biochem Mol Biol 26: 1–52 Wu B, Gu MJ, Heydari AR et al. (1993) The effect of age on the synthesis of two heat shock proteins in the hsp70 family. J Gerontol 48: B50-B56 Youngman LD, Park J-YK and Ames BN (1992) Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc Natl Acad Sci USA 89: 9112–9116 Yuh KCM and Gafni A (1987) Reversal of age-related effects in rat muscle phosphoglycerate kinase. Proc Natl Acad Sci USA 84: 7458–7462