Molecular basis of cooperativity in vertebrate muscle thin filaments
Tóm tắt
Extraction of as little as one troponin C per regulatory strand on a thin filament reduces the slope of the pCa/tension relation thus the regulatory units along a thin filament of rabbit psoas fibers are linked cooperatively so that a thin filament activates as a unit. This explains why the pCa/tension relation in skinned fibers has a slope much higher than can be expected by binding of Ca2+ to one regulatory unit (Brandt et al. 1980;Brandt et al. 1982). These results also show that troponin C is the only myfibrillar component responsible for calcium sensitivity in psoas muscle.
Tài liệu tham khảo
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