Molecular and Neuroanatomical Properties of the Endogenous Opioid System: Implications for Treatment of Opiate Addiction

Akil, 1976, Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist, Science, 191, 961, 10.1126/science.1251210 Akil, 1972, Comparison chez le rat entre l'analgesie induite par stimulation de la substance grise peri-aqueducale et l'analgesie morphinique, C R Acad Sci Paris Ser D, 274, 3603 Akil, 1994, Cloning of kappa opioid receptors: Functional significance and future directions Akil, 1984, Endogenous opioids: Biology and function, 223 Akil, 1981, Opiate binding properties of naturally occurring N- and C-terminus modified beta-endorphin, Peptides, 2, 289, 10.1016/S0196-9781(81)80121-0 Avidor-Reiss, 1996, Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma, J. Biol. Chem., 271, 21309, 10.1074/jbc.271.35.21309 Bals-Kubik, 1988, β-Endorphin-(1-27) is a naturally occurring antagonist of the reinforcing effects of opioids, Naunyn-Schmiedeberg's Arch. Pharmacol., 338, 392, 10.1007/BF00172115 Beckett, 1954, Synthetic analgesics: Stereochemical considerations, J. Pharm. Pharmacol., 6, 986, 10.1111/j.2042-7158.1954.tb11033.x Befort, 1994, Chromosomal localization of the δ opioid receptor gene to human 1p34.3–p36.1 and mouse 4D bands byin situ, Genomics, 20, 143, 10.1006/geno.1994.1146 Bloom, 1978, Beta-endorphin: Cellular localization, electrophysiological and behavioral effects, 89 Bunzow, 1994, Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type, FEBS Lett., 347, 279, 10.1016/0014-5793(94)00561-3 Burt, 1996, Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: Effects of receptor expression levels and comparisons with G-protein activation, Biochem. J., 320, 227, 10.1042/bj3200227 Chang, 1979, Multiple opiate receptors: Enkephalins and morphine bind to receptors of different specificity, J. Biol. Chem., 254, 2610 Chen, 1993, Molecular cloning and functional expression of a μ-opioid receptor from rat brain, Mol. Pharmacol., 44, 8 Chesselet, 1983, Local and distal effects induced by unilateral striatal application of opiates in the absence or in the presence of naloxone on the release of dopamine in both caudate nuclei and substantive nigrae of the cat, Brain Res., 258, 229, 10.1016/0006-8993(83)91146-0 Childers, 1993, Opioid receptor-coupled second messenger systems, 189 Cooper, 1991, Interactions between endogenous opioids and dopamine: Implications for reward and aversion, 331 Curran, 1995, Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: A doublein situ, J. Comp. Neurol., 361, 57, 10.1002/cne.903610106 Devine, 1993, Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release:In vivo, J. Pharmacol. Exp. Ther., 266, 1236 Devine, 1996, The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion, Brain Res., 727, 225, 10.1016/0006-8993(96)00476-3 Devine, 1996, Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ, Neurochem. Res., 21, 1387, 10.1007/BF02532380 Devine, 1994, Self-administration of morphine, DAMGO and DPDPE into the ventral tegmental area of rats, J. Neurosci., 14, 1978, 10.1523/JNEUROSCI.14-04-01978.1994 Di Chiara, 1988, Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats, J. Pharmacol. Exp. Ther., 244, 1067 Evans, 1992, Cloning of a delta opioid receptor by functional expression, Science, 258, 1952, 10.1126/science.1335167 Fukuda, 1993, Primary structures and expression from cDNAs of rat opioid receptor δ- and μ-subtypes, FEBS Lett., 327, 311, 10.1016/0014-5793(93)81011-N Fukuda, 1996, Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells, J. Neurochem., 67, 1309, 10.1046/j.1471-4159.1996.67031309.x Fukuda, 1995, Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ- and μ-opioid receptors, FEBS Lett., 373, 177, 10.1016/0014-5793(95)01034-C Gaudriault, 1997, Receptor-induced internalization of selective peptidic μ and opioid ligands, J. Biol. Chem., 272, 2880, 10.1074/jbc.272.5.2880 Gether, 1993, Different binding epitopes on the NK1, Nature, 362, 345, 10.1038/362345a0 Goldstein, 1971, Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain, Proc. Natl. Acad. Sci. USA, 68, 1742, 10.1073/pnas.68.8.1742 Goldstein, 1979, Dynorphin-(1-13), an extraordinarily potent opioid peptide, Proc. Natl. Acad. Sci. USA, 76, 6666, 10.1073/pnas.76.12.6666 Graybiel, 1990, Neurotransmitters and neuromodulators in the basal ganglia, TINS, 13, 244 Grevel, 1983, An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans, Science, 221, 1198, 10.1126/science.6310750 Gulya, 1986, Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors, Life Sci., 30, 2221, 10.1016/0024-3205(86)90574-6 Gutstein, 1997, Opioid effects on protein kinase signaling cascades, Anesthesiology, 10.1097/00000542-199711000-00016 Handa, 1981, Analogues of beta-LPH 61–64 possessing selective agonist activity at mu opiate receptors, Eur. J. Pharmacol., 70, 531, 10.1016/0014-2999(81)90364-2 Heimer, 1982, Ventral striatum and ventral pallidum. Components of the motor system?, TINS, 5, 83 Heimer, 1991, Specificity in the projection patterns of accumbal core and shell in the rat, Neuroscience, 41, 89, 10.1016/0306-4522(91)90202-Y Hokfelt, 1977, The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system, Neurosci. Lett., 5, 25, 10.1016/0304-3940(77)90160-4 Hughes, 1975, Identification of two related pentapeptides from the brain with potent opiate agonist activity, Nature, 258, 577, 10.1038/258577a0 Jiang, 1991, Differential antagonism of opioid delta antinociception by [d256, J. Pharmacol. Exp. Ther., 257, 1069 Keith, 1996, Morphine activates opioid receptors without causing their rapid internalization, J. Biol. Chem., 271, 19021, 10.1074/jbc.271.32.19021 Kieffer, 1992, The delta opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization, Proc. Natl. Acad. Sci. USA, 89, 12048, 10.1073/pnas.89.24.12048 Kosterlitz, 1975, In vitro, Annu. Rev. Pharmacol., 15, 29, 10.1146/annurev.pa.15.040175.000333 Li, 1976, Isolation and structure of a triakontapeptide with opiate activity from camel pituitary glands, Proc. Natl. Acad. Sci. USA, 73, 1145, 10.1073/pnas.73.4.1145 Li, 1996, The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors, Mol. Pharmacol., 50, 599 Lord, 1977, Endogenous opioid peptides: Multiple agonists and receptors, Nature (London), 267, 495, 10.1038/267495a0 Mains, 1977, Common precursor to corticotropins and endorphins, Proc. Natl. Acad. Sci. USA, 74, 3014, 10.1073/pnas.74.7.3014 Mansour, 1994, Mu, delta and kappa opioid receptor mRNA expression in the rat CNS: Anin situ, J. Comp. Neurol., 350, 412, 10.1002/cne.903500307 Mansour, 1994, Kappa1, Cell. Mol. Neurosci., 5, 124, 10.1006/mcne.1994.1015 Mansour, 1994, Mu-opioid receptor mRNA expression in the rat CNS: Comparison to mu-receptor binding, Brain Res., 643, 245, 10.1016/0006-8993(94)90031-0 Mansour, 1995, The cloned μ, δ and κ receptors and their endogenous ligands: Evidence for two opioid peptide recognition cores, Brain Res., 700, 89, 10.1016/0006-8993(95)00928-J Mansour, 1988, Anatomy of CNS opioid receptors, TINS, 11, 308 Mansour, 1992, Site-directed mutagenesis of the human D2 receptor, Eur. J. Pharmacol., 227, 205, 10.1016/0922-4106(92)90129-J Mansour, 1997, Key residues defining the m opioid receptor binding pocket: A site-directed mutagenesis study, J. Neurochem., 68, 344, 10.1046/j.1471-4159.1997.68010344.x Martin, 1976, The effects of morphine and nalorphine-like drugs in nondependent and morphine-dependent chronic spinal dog, J. Pharmacol. Exp. Ther., 197, 517 Meng, 1995, A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ opioid receptors: Potential role of extracellular domains, J. Biol. Chem., 270, 12730, 10.1074/jbc.270.21.12730 Meng, 1996, Mapping the receptor domains critical for the binding selectivity of δ opioid receptor ligands, Eur. J. Pharmacol., 311, 285, 10.1016/0014-2999(96)00431-1 Meng, 1993, Cloning and pharmacological characterization of a rat kappa opioid receptor, Proc. Natl. Acad. Sci. USA, 90, 9954, 10.1073/pnas.90.21.9954 Mestek, 1995, The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C, J. Neurosci., 15, 2396, 10.1523/JNEUROSCI.15-03-02396.1995 Meunier, 1995, Isolation and structure of the endogenous agonist of opioid receptor-like ORL1, Nature, 377, 532, 10.1038/377532a0 Minami, 1993, Cloning and expression of a cDNA for the rat κ-opioid receptor, FEBS Lett., 329, 291, 10.1016/0014-5793(93)80240-U Misawa, 1990, Kappa-opioid agonist inhibits phospholipasa C, possibly via an inhibition of G-protein activity, Neurosci. Lett., 112, 324, 10.1016/0304-3940(90)90224-W Mollereau, 1994, ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization, FEBS Lett., 341, 33, 10.1016/0014-5793(94)80235-1 Mosberg, 1983, Bis-pencillamine enkephalins possess highly improved specificity toward delta opioid receptors, Proc. Natl. Acad. Sci. USA, 80, 5871, 10.1073/pnas.80.19.5871 Mulder, 1991, Pharmacological profile of various kappa-agonists at kappa-, mu- and delta-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain, Br. J. Pharmacol., 102, 518, 10.1111/j.1476-5381.1991.tb12203.x Nakanishi, 1979, Nucleotide sequence of clones cDNA for bovine corticotropin-beta-lipotropin precursor, Nature, 278, 423, 10.1038/278423a0 Narita, 1995, Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse, Eur. J. Pharmacol., 280, R1, 10.1016/0014-2999(95)00322-C Negri, 1991, Evidence for two subtypes of δ opioid receptors in rat brain, Eur. J. Pharmacol., 196, 335, 10.1016/0014-2999(91)90450-5 Oka, 1980, Enkephalin receptor in the rabbit ileum, Life Sci., 38, 1889 Pei, 1995, Agonist-dependent phosphorylation of the mouse delta-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C, Mol. Pharmacol., 48, 173 Periyasamy, 1990, Kappa opioid receptors stimulate phosphoinositide turnover in rat brain, Life Sci., 47, 219, 10.1016/0024-3205(90)90323-J Pert, 1973, Opiate receptor; demonstration in nervous tissue, Science, 179, 1011, 10.1126/science.179.4077.1011 Piros, 1996, Functional analysis of cloned opioid receptors in transfected cell lines, Neurochem. Res., 21, 1271, 10.1007/BF02532368 Portoghese, 1987, Binaltorphimine and norbinaltorphimine, potent and selective κ-opioid receptor antagonists, Life Sci., 40, 1287, 10.1016/0024-3205(87)90585-6 Portoghese, 1988, Natrindole, a highly selective and potent non-peptide delta opioid receptor antagonist, Eur. J. Pharmacol., 146, 185, 10.1016/0014-2999(88)90502-X Prather, 1995, Properties of a kappa-opioid receptor expressed in CHO cells: Interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors, Mol. Brain Res., 29, 336, 10.1016/0169-328X(94)00264-F Reinscheid, 1995, Orphanin FQ: A neuropeptide that activates an opioid-like G-protein-coupled receptor, Science, 270, 792, 10.1126/science.270.5237.792 Rothman, 1988, β-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence, J. Pharmacol. Exp. Ther., 247, 405 Schulz, 1979, Selective receptors for β-endorphin on the rat vas deferens, Life Sci., 24, 843, 10.1016/0024-3205(79)90368-0 Schwyzer, 1986, Molecular mechanism of opioid receptor selection, Biochemistry, 25, 6335, 10.1021/bi00368a075 Shippenberg, 1987, Motivational properties of opioids: Evidence that an activation of delta-receptors mediates reinforcement processes, Brain Res., 436, 234, 10.1016/0006-8993(87)91667-2 Shippenberg, 1991, Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists, Psychopharmacology, 103, 209, 10.1007/BF02244205 Shippenberg, 1992, Conditioning of opioid reinforcement: Neuroanatomical and neurochemical substrates, Ann. N.Y. Acad. Sci., 654, 347, 10.1111/j.1749-6632.1992.tb25980.x Simon, 1973, Stereospecific binding of the potent narcotic analgesic 3H-etorphine to rat brain homogenate, Proc. Natl. Acad. Sci. USA, 70, 1947, 10.1073/pnas.70.7.1947 Sofuoglu, 1991, Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes, J. Pharmacol. Exp. Ther., 257, 676 Strader, 1988, Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function, J. Biol. Chem., 263, 10267 Surratt, 1994, Mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity, J. Biol. Chem., 269, 20548 Terenius, 1973, Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat brain cortex, Acta Pharmacol. Toxicol. (Copenh), 32, 317, 10.1111/j.1600-0773.1973.tb01477.x Thompson, 1993, Cloning and pharmacological characterization of a rat mu opioid receptor, Neuron, 11, 903, 10.1016/0896-6273(93)90120-G Trapaidze, 1996, Sequestration of the opioid receptor: Role of the c terminus in agonist-mediated internalization, J. Biol. Chem., 271, 29279, 10.1074/jbc.271.46.29279 Trujillo, 1991, Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801, Science, 251, 85, 10.1126/science.1824728 Tseng, 1986, Beta-endorphin (1-27) inhibits the spinal beta-endorphin-induced release of met-enkephalin, Int. J. Pept. Protein Res., 27, 394, 10.1111/j.1399-3011.1986.tb01033.x Ueda, 1995, Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes, J. Neurosci., 15, 7485, 10.1523/JNEUROSCI.15-11-07485.1995 Von Voightlander, 1983, U-50, 488H: A selective and structurally novel non-mu (kappa) opioid agonist, J. Pharmacol. Exp. Ther., 24, 111 Wang, 1994, Human μ opiate receptor cDNA and genomic clones, pharmacologic characterization and chromosomal assignment, FEBS Lett., 338, 217, 10.1016/0014-5793(94)80368-4 Wang, 1993, μ Opiate receptor: cDNA cloning and expression, Proc. Natl. Acad. Sci. USA, 90, 10230, 10.1073/pnas.90.21.10230 Wang, 1994, Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for mu/kappa chimeras, J. Biol. Chem., 269, 25966 Wang, 1995, Studies on μ and δ opioid receptor selectivity utilizing chimeric and site-mutagenized receptors, Proc. Natl. Acad. Sci. USA, 92, 12436, 10.1073/pnas.92.26.12436 Watson, 1996, A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands, Neurobiol. Dis., 3, 87, 10.1006/nbdi.1996.0009 Watson, 1981, Dynorphin immunocytochemical localization in brain and peripheral nervous system: Preliminary studies, Proc. Natl. Acad. Sci. USA, 78, 1260, 10.1073/pnas.78.2.1260 Watson, 1978, Evidence for two separate opiate peptide neuronal systems, Nature, 275, 226, 10.1038/275226a0 Willner, 1991, The mesolimbic dopamine system Wolozin, 1981, Classification of multiple morphine and enkephalin binding sites in the central nervous system, Proc. Natl. Acad. Sci. USA, 78, 6181, 10.1073/pnas.78.10.6181 Xue, 1995, The third extracellular loop of the μ opioid receptor is important for agonist selectivity, J. Biol. Chem., 270, 12977 Xue, 1994, Differential binding domains of peptide and non-peptide ligands in the cloned rat κ opioid receptor, J. Biol. Chem., 269, 30195 Yasuda, 1994, Localization of the kappa opioid receptor gene to human chromosome band 8q11.2, Genomics, 19, 596, 10.1006/geno.1994.1117 Yasuda, 1993, Cloning and functional comparison of kappa and delta opioid receptors from mouse brain, Proc. Natl. Acad. Sci. USA, 90, 6736, 10.1073/pnas.90.14.6736 Zagon, 1989, Characterization of zeta: A new opioid receptor involved in growth, Brain Res., 482, 297, 10.1016/0006-8993(89)91192-X Zahm, 1988, Ventral striatopallidal parts of the basal ganglia in the rat. I. Neurochemical compartmentation as reflected by the distributions of neurotensin and substance P immunoreactivity, J. Comp. Neurol., 272, 516, 10.1002/cne.902720406