Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity

Chambers, 2001, The aminoglycosides, 1219

Mingeot-Leclercq, 1999, Aminoglycosides: nephrotoxicity, Antimicrob. Agents Chemother., 43, 1003, 10.1128/AAC.43.5.1003

Just, 1977, The renal handling of polybasic drugs. 1. Gentamicin and aprotinin in intact animals, Naunyn-Schmiedeberg’s Arch. Pharmacol., 300, 57, 10.1007/BF00505080

Silverblatt, 1979, Autoradiography of gentamicin uptake by the rat proximal tubule cell, Kidney Int., 15, 335, 10.1038/ki.1979.45

Vandewalle, 1981, Gentamicin incorporation along the nephron: Autoradiographic study on isolated tubules, Kidney Int., 19, 529, 10.1038/ki.1981.50

Saito, 1986, Mechanisms of gentamicin transport in kidney epithelial cell line (LLC-PK1), J. Pharmacol. Exp. Ther., 238, 1071

Inui, 1988, Aminoglycoside-induced alterations in apical membranes of kidney epithelial cell line (LLC-PK1), Am. J. Physiol., 254, C251, 10.1152/ajpcell.1988.254.2.C251

Hori, 1992, Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line (LLC-PK1), J. Pharmacol. Exp. Ther., 261, 1200

Takano, 1994, Transport of gentamicin and fluid-phase endocytosis markers in the LLC-PK1 kidney epithelial cell line, J. Pharmacol. Exp. Ther., 268, 669

Josepovitz, 1982, Inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polycations, J. Pharmacol. Exp. Ther., 223, 314

Giuliano, 1986, In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats, J. Pharmacol. Exp. Ther., 236, 470

Molitoris, 1997, Cell biology of aminoglycoside nephrotoxicity: newer aspects, Curr. Opin. Nephrol. Hypertens., 6, 384, 10.1097/00041552-199707000-00013

Schacht, 1979, Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney, Arch. Otorhinolaryngol., 224, 129, 10.1007/BF00455236

Schacht, 1978, Purification of polyphosphoinositides by chromatography on immobilized neomycin, J. Lipid Res., 19, 1063, 10.1016/S0022-2275(20)40692-3

Just, 1977, The renal handling of polybasic drugs. 2. In vitro studies with brush border and lysosomal preparations, Naunyn-Schmiedeberg’s Arch. Pharmacol., 300, 67, 10.1007/BF00505081

Lipsky, 1980, Gentamicin uptake by renal tubule brush border membrane vesicles, J. Pharmacol. Exp. Ther., 215, 390

Sastrasinh, 1982, Identification of the aminoglycoside binding site in rat renal brush border membranes, J. Pharmacol. Exp. Ther., 222, 350

Laurent, 1990, Aminoglycoside-induced renal phospholipidosis and nephrotoxicity, Biochem. Pharmacol., 40, 2383, 10.1016/0006-2952(90)90078-Y

Kaloyanides, 1992, Drug-phospholipid interactions: role in aminoglycoside nephrotoxicity, Ren. Fail., 14, 351, 10.3109/08860229209106642

Ali, 1995, Gentamicin nephrotoxicity in humans and animals: some recent research, Gen. Pharmac., 26, 1477, 10.1016/0306-3623(95)00049-6

Humes, 1982, Clinical and pathophysiological aspects of aminoglycoside nephrotoxicity, Am. J. Kidney Dis., 2, 5, 10.1016/S0272-6386(82)80039-5

Williams, 1987, Correlation between renal membrane binding and nephrotoxicity of aminoglycosides, Antimicrob. Agents Chemother., 31, 570, 10.1128/AAC.31.4.570

Williams, 1986, Inhibition of renal membrane binding and nephrotoxicity of aminoglycosides, J. Pharmcol. Exp. Ther., 237, 919

Ramsammy, 1989, Polyaspartic acid protects against gentamicin nephrotoxicity in the rat, J. Pharmcol. Exp. Ther., 250, 149

Kishore, 1992, Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against gentamicin-induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats, J. Pharmacol. Exp. Ther., 262, 424

Todd, 1995, Renal brush border membrane vesicle aminoglycoside binding and nephrotoxicity, J. Pharmacol. Exp. Ther., 274, 258

Moestrup, 1995, Evidence that epithelial glycoprotein 330/ megalin mediates uptake of polybasic drugs, J. Clin. Invest., 96, 1404, 10.1172/JCI118176

Kerjaschki, 1982, The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border, Proc. Natl. Acad. Sci. USA, 79, 5557, 10.1073/pnas.79.18.5557

Christensen, 1992, Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein, J. Histochem. Cytochem., 40, 1481, 10.1177/40.10.1382088

Willnow, 1992, Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance, J. Biol. Chem., 267, 26172, 10.1016/S0021-9258(18)35732-6

Kounnas, 1992, The 39-kDa receptor-associated protein interacts with two members of the low-density lipoprotein receptor family, a2-macroglobulin receptor and glycoprotein 330, J. Biol. Chem., 267, 21162, 10.1016/S0021-9258(19)36811-5

Moestrup, 1994, The α2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands, Biochim. Biophys. Acta, 1197, 197, 10.1016/0304-4157(94)90005-1

Makker, 1993, Analysis of glomeruli-eluted gp330 autoantibodies and of Gp330 antigen of Heymann nephritis, J. Immunol., 151, 6500, 10.4049/jimmunol.151.11.6500

Raychowdhury, 1989, Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor, Science, 244, 1163, 10.1126/science.2786251

Saito, 1994, Complete cloning and sequencing of rat gp330/“megalin”, a distinctive member of the low density lipoprotein receptor gene family, Proc. Natl. Acad. Sci. USA, 91, 9725, 10.1073/pnas.91.21.9725

Hjälm, 1996, Cloning and sequencing of human gp330, a Ca2+-binding receptor with potential intracellular signaling properties, Eur. J. Biochem., 239, 132, 10.1111/j.1432-1033.1996.0132u.x

Willnow, 1999, Lipoprotein receptors: new roles for ancient proteins, Nat. Cell Biol., 1, E157, 10.1038/14109

Howell, 2001, The LDL receptor gene family: signaling functions during development, Curr. Opin. Neurobiol., 11, 74, 10.1016/S0959-4388(00)00176-8

Krieger, 1994, Structures and functions of mutiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP), Annu. Rev. Biochem., 63, 601, 10.1146/annurev.bi.63.070194.003125

Davis, 1987, Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region, Nature, 326, 760, 10.1038/326760a0

Chen, 1990, NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low-density lipoprotein receptor, J. Biol. Chem., 265, 3116, 10.1016/S0021-9258(19)39742-X

Takeda, 2003, Identification of an apical sorting determinant in the cytoplasmic tail of megalin, Am. J. Physiol. Cell. Physiol., 284, C1105, 10.1152/ajpcell.00514.2002

Oleinikov, 2000, Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin, Biochem. J., 347, 613, 10.1042/0264-6021:3470613

Xu, 1995, Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product, J. Biol. Chem., 270, 14184, 10.1074/jbc.270.23.14184

Morris, 2002, Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport, EMBO J., 21, 1555, 10.1093/emboj/21.7.1555

Fazili, 1999, Disabled-2 inactivation is an early step in ovarian tumorigenicity, Oncogene, 18, 3104, 10.1038/sj.onc.1202649

Rader, 2000, Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin, J. Am. Soc. Nephrol., 11, 2167, 10.1681/ASN.V11122167

Christensen, 1998, Membrane receptors for endocytosis in the renal proximal tubule, Int. Rev. Cytol., 180, 237, 10.1016/S0074-7696(08)61772-6

Moestrup, 1993, Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes, J. Biol. Chem., 268, 16564, 10.1016/S0021-9258(19)85456-X

Zheng, 1994, Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, Gp330 and LRP/α2 MR, and the receptor-associated protein (RAP), J. Histochem. Cytochem., 42, 531, 10.1177/42.4.7510321

Lundgren, 1997, Tissue distribution of human gp330/megalin, a putative Ca2+ -sensing protein, J. Histochem. Cytochem., 45, 383, 10.1177/002215549704500306

Christensen, 1995, Segmental distribution of the endocytosis receptor gp330 in renal prox imal tubules, Eur. J. Cell. Biol., 66, 349

Christensen, 2002, Megalin and cubilin: Multifunctional endocytic receptors, Nat. Rev. Mol. Cell Biol., 3, 256, 10.1038/nrm778

Orlando, 1997, Identification of the second cluster of ligand-binding repeats in megalin as a site for receptorligand interactions, Proc. Natl. Acad. Sci. USA, 94, 2368, 10.1073/pnas.94.6.2368

Willnow, 1996, Defective forebrain development in mice lacking gp330/megalin, Proc. Natl. Acad. Sci. USA, 93, 8460, 10.1073/pnas.93.16.8460

Leheste, 1999, Megalin knockout mice as an animal model of low molecular weight proteinuria, Am. J. Pathol., 155, 1361, 10.1016/S0002-9440(10)65238-8

Nykjaer, 1999, An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3, Cell, 96, 507, 10.1016/S0092-8674(00)80655-8

Leheste, 2003, Hypocalcemia and osteopathy in mice with kidneyspecific megalin gene defect, FASEB J., 17, 247, 10.1096/fj.02-0578fje

Gburek, 2003, Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin, Am. J. Physiol. Renal Physiol., 285, F451, 10.1152/ajprenal.00062.2003

Christensen, 1999, Essential role of megalin in renal proximal tubule for vitamin homeostasis, J. Am. Soc. Nephrol., 10, 2224, 10.1681/ASN.V10102224

Takano, 2002, Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney, Kidney Int., 62, 1707, 10.1046/j.1523-1755.2002.00623.x

Cui, 1996, Megalin/gp330 mediates uptake of albumin in renal proximal tubule, Am. J. Physiol., 271, F900

Birn, 2000, Cubilin is an albumin binding protein important for renal tubular albumin reabsorption, J. Clin. Invest., 105, 1353, 10.1172/JCI8862

Zhai, 2000, Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney, Kidney Int., 58, 1523, 10.1046/j.1523-1755.2000.00314.x

Moestrup, 2000, Cubilin, a high-density lipoprotein receptor, Curr. Opin. Lipidol., 11, 133, 10.1097/00041433-200004000-00005

Kozyraki, 2001, Cubilin, a multifunctional epithelial receptor: an overview, J. Mol. Med., 79, 161, 10.1007/s001090100193

Verroust, 2002, The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology, Kidney Int., 62, 745, 10.1046/j.1523-1755.2002.00501.x

Nagai, 2001, Role of megalin in renal handling of aminoglycosides, Am. J. Physiol, Renal Physiol., 281, F337, 10.1152/ajprenal.2001.281.2.F337

Humes, 1984, Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity, J. Clin. Invest., 73, 134, 10.1172/JCI111184

Quarum, 1984, Increasing dietary calcium moderates experimental gentamicin nephrotoxicity, J. Lab. Clin. Med., 103, 104

Elliott, 1992, Aminoglycosidemediated calciuresis, J. Pharmacol. Exp. Ther., 262, 151

Elliott, 2000, Gentamicin effects on urinary electrolyte excretion in healthy subjects, Clin. Pharmacol. Ther., 67, 16, 10.1067/mcp.2000.103864

Nagai, 2002, Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney, J. Pharm. Pharmacol., 54, 1491, 10.1211/00223570272

Schmitz, 2002, Megalin deficiency offers protection from renal aminoglycoside accumulation, J. Biol. Chem., 277, 618, 10.1074/jbc.M109959200

Birn, 2000, Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules, J. Am. Soc. Nephrol., 11, 191, 10.1681/ASN.V112191

Bergeron, 1996, Specific effect of maleate on an apical membrane glycoprotein (gp330) in proximal tubule of rat kidneys, Am. J. Phys iol., 271, F908

Farquhar, 1995, The Heymann nephritis antigenic complex: megalin (gp330) and RAP, J. Am. Soc. Nephrol., 6, 35, 10.1681/ASN.V6135

Willnow, 1998, Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors, Biol. Chem., 379, 1025

Watanabe, 2004, Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor an tagonists, J. Control. Release, 95, 423, 10.1016/j.jconrel.2003.12.005

Yu, 1990, gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein, Science, 250, 1413, 10.1126/science.2255912

Janmey, 1992, Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin, J. Biol. Chem., 267, 11818, 10.1016/S0021-9258(19)49772-X

Prehoda, 2000, Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex, Science, 290, 801, 10.1126/science.290.5492.801

Ali, 2003, Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research, Food Chem. Toxicol., 41, 1447, 10.1016/S0278-6915(03)00186-8

Slaughter, 1998, Economic impact of aminoglycoside toxicity and its prevention through therapeutic drug monitoring, Pharmacoeconomics, 14, 385, 10.2165/00019053-199814040-00005

Verpooten, 1989, Once-daily dosing decreases renal accumulation of gentamicin and netilmicin, Clin. Pharmacol. Ther., 45, 22, 10.1038/clpt.1989.4

Hitt, 1997, Pharmacoeconomic impact of once-daily aminoglycoside administration, Pharmacotherapy, 17, 810, 10.1002/j.1875-9114.1997.tb03760.x

Bass, 1998, Pharmacokinetics of once-daily gentamicin dosing in pediatric patients, J. Pediatr. Surg., 33, 1104, 10.1016/S0022-3468(98)90540-1

Beauchamp, 2001, Aminoglycoside nephrotoxicity: do time and frequency of administration matter?, Curr Opin. Crit. Care, 7, 401, 10.1097/00075198-200112000-00006

Freeman, 1997, Once-daily dosing of aminoglycosides: review and recommendations for clinical practice, J. Antimicrob. Chemother., 39, 677, 10.1093/jac/39.6.677

Martin, 2003, Once-daily aminoglycoside dosing: where are we now?, J. Crit. Care, 18, 113, 10.1053/jcrc.2003.50007

Kounnas, 1994, Immunological localization of glycoprotein 330, low-density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic tissues, In Vivo, 8, 343

Mizuta, 1999, Ultrastructural localization of megalin in the rat cochlear duct, Hearing Res., 129, 83, 10.1016/S0378-5955(98)00221-4

Hashino, 1995, Endocytosis of aminoglycoside antibiotics in sensory hair cells, Brain Res., 704, 135, 10.1016/0006-8993(95)01198-6

Christensen, 1999, Evidence for an essential role of megalin in transepithelial transport of retinol, J. Am. Soc. Nephrol., 10, 685, 10.1681/ASN.V104685

Moestrup, 1996, Megalin-mediated endocytosis of transcobalamin-vitamin-B 12 complexes suggests a role of the receptor in vitamin-B12 homeostasis, Proc. Natl. Acad. Sci. USA, 93, 8612, 10.1073/pnas.93.16.8612

Gburek, 2002, Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin, J. Am. Soc. Nephrol., 13, 423, 10.1681/ASN.V132423

Sousa, 2000, Evidence for the role of megalin in renal uptake of transthyretin, J. Biol. Chem., 275, 38176, 10.1074/jbc.M002886200

Stefansson, 1995, Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100, J. Biol. Chem., 270, 19417, 10.1074/jbc.270.33.19417

Moestrup, 1998, β2 glycoprotein-I (apolipoprotein H) and β2-glycoproteinI-phospholipid complex harbor a recognition site for the endocytic receptor megalin, J. Clin. Invest., 102, 902, 10.1172/JCI3772

Kounnas, 1995, Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin, J. Biol. Chem., 270, 13070, 10.1074/jbc.270.22.13070

Orlando, 1998, Megalin is an endocytic receptor for insulin, J. Am. Soc. Nephrol., 9, 1759, 10.1681/ASN.V9101759

Hilpert, 1999, Megalin antagonizes activation of the parathyroid hormone receptor, J. Biol. Chem., 274, 5620, 10.1074/jbc.274.9.5620

Zheng, 1998, Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg), Endocrinology, 139, 1462, 10.1210/endo.139.3.5978

Chan, 2000, Trichosanthin interacts with and enters cells via LDL receptor family members, Biochem. Biophys. Res. Commun., 270, 453, 10.1006/bbrc.2000.2441

Kounnas, 1993, Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro, J. Biol. Chem., 268, 14176, 10.1016/S0021-9258(19)85224-9

Kanalas, 1991, Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen, J. Biol. Chem., 266, 10825, 10.1016/S0021-9258(18)99093-9

Stefansson, 1995, gp330 on type II pneumocytes mediates endocytosis leading to degradation of prourokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex, J. Cell Sci, 108, 2361, 10.1242/jcs.108.6.2361

Orlando, 1992, gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex, Proc. Natl. Acad. Sci. USA, 89, 6698, 10.1073/pnas.89.15.6698