Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats

Badimon, 2010, Nutraceuticals and atherosclerosis: human trials, Cardiovasc Ther, 28, 202, 10.1111/j.1755-5922.2010.00189.x Changizi-Ashtiyani, 2013, The effects of Portulaca oleracea alcoholic extract on induced hypercholesteroleomia in rats, Zah J Res Med Sci, 15, 34 Bocan, 1998, Animal models of atherosclerosis and interpretation of drug intervention studies, Curr Pharm Des, 4, 37 Kabiri, 2011, Lipid lowering by hydroalcoholic extracts of Amaranthus Caudatus L. induces regression of rabbits atherosclerotic lesions, Lipids Health Dis, 10, 1, 10.1186/1476-511X-10-89 Wang, 2013, Influences ofsimvastatinon vascular endothelial function of patients with coronaryheartdisease complicated with congestiveheartfailure, Eur Rev Med Pharmacol Sci, 17, 1590 Minder, 2013, Statins for primary preventionofcardiovascular disease: the benefits outweigh the risks, Curr Opin Cardiol, 28, 554, 10.1097/HCO.0b013e32836429e6 Jaiswal, 2012, Experimental evaluation of analgesic andanti-inflammatoryactivity of simvastatin and atorvastatin, Indian J Pharmacol, 44, 475, 10.4103/0253-7613.99311 Matalka, 2013, Antioxidant activity of simvastatin prevents l-arginine-induced acute toxicity of pancreas, Int J Physiol Pathophysiol Pharmacol, 5, 102 Deucher, 1988, EDTA chelation (an antioxidant strategy), J Adv Med, 1, 182 Modi, 2007, Combined administration of selenium and meso-2, 3-dimercaptosuccinic acid on arsenic mobilization and tissue oxidative stress in chronic arsenic-exposed male rats, Indian J Pharmacol, 39, 107, 10.4103/0253-7613.32530 Sompamit, 2010, Reversal of cadmium-induced vascular dysfunction and oxidative stress by meso-2,3-dimercaptosuccinic acidin mice, Toxicol Lett, 198, 77, 10.1016/j.toxlet.2010.04.007 Ashour, 2007, Blood, serum glucose and renal parameters in lead-loaded albino rats and treatment with some chelating agents and natural oils, Turk J Biol, 31, 25 Malinovska, 1983, The therapeutic effect of glucagon and chelation III on the arterial wall after experimental lipidosis and calcification, Scr Med (Brno), 56, 391 Elihu, 1998, Chelation therapy in cardiovascular disease: ethylenediaminetetraacetic acid, deferoxamine, and dexrazoxane, J Clin Pharmacol, 38, 101, 10.1002/j.1552-4604.1998.tb04397.x Shrihari, 2006, Role of EDTA chelation therapy in cardiovascular diseases, Natl Med J India, 19, 24 Lamas, 2013, Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial, JAMA, 309, 1241, 10.1001/jama.2013.2107 Bonetti, 2003, Statin effects beyond lipid lowering – are they clinically relevant?, Eur Heart J, 24, 225, 10.1016/S0195-668X(02)00419-0 Tang, 2006, HypercholesterolemiaacceleratesvascularcalcificationinducedbyexcessivevitaminDviaoxidativestress, Calcif Tissue Int, 79, 326, 10.1007/s00223-006-0004-8 Jin, 2011, Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild lead-poisoning, Environ Toxicol Pharmacol, 31, 137, 10.1016/j.etap.2010.09.015 Owczarek, 2012, Effects of 4-week administration ofsimvastatinin different doses onheartrate and blood pressure after metoprolol injection in normocholesterolaemic and normotensiverats, Arch Med Sci, 8, 17, 10.5114/aoms.2012.27275 Pengzhan, 2003, Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta), Pharmacol Res, 48, 543, 10.1016/S1043-6618(03)00215-9 Friedewald, 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, 18, 499, 10.1093/clinchem/18.6.499 Hostmark, 1991, Lipoprotein-related coronary risk factors in patients with angiographically defined coronary artery disease and controls: improved group separation by indexes reflecting the balance between low-and high-density lipoproteins, Coronary artery dis, 2, 679 Miranda, 2001, A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite, Nitric oxide, 5, 62, 10.1006/niox.2000.0319 Mihara, 1978, Determination of malondialdehyde precursor in tissues by thiobarbituric acid test, Anal Biochem, 86, 271, 10.1016/0003-2697(78)90342-1 Marklund, 1974, Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur J Biochem, 47, 469, 10.1111/j.1432-1033.1974.tb03714.x Beutler, 1963, Kelly BM. Improved method for the determination of blood glutathione, J Lab Clin Med, 61, 882 Essalihi, 2005, Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase, Circulation, 112, 1628, 10.1161/CIRCULATIONAHA.104.528984 Martins, 2011, Immunolocalization of nitric oxide synthase isoforms in human archival and rat tissues, and cultured cells, J Neurosci Methods, 198, 16, 10.1016/j.jneumeth.2011.02.024 Abdel Maksoud, 2012, Antihyperlipidemic effect of iced black tea (Camellia sinensis) extract, 3, 8 Amanolahi, 2013, Effects of ethanolic extract of green tea on decreasing the level of lipid profile in rat, AJP, 3, 98 McDonagh, 1982, The effect of intravenous disodium ethylenediaminetetraacetic acid (EDTA) upon blood cholesterol in a private practice environment, J Int Acad Prevent Med, 7, 5 Uhl, 1992, EDTA reduces liver cholesterol content in cholesterol-fed rabbits, Atherosclerosis, 96, 181, 10.1016/0021-9150(92)90064-N Hininger, 2005, Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy, Free Radic Biol Med, 38, 1565, 10.1016/j.freeradbiomed.2005.02.016 Roussel, 2009, EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation, Altern Med Rev, 14, 56 Flora, 2011, Co-administration of meso 2,3-dimercaptosuccinic acidmonoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats, Clin Exp Pharmacol Physiol, 38, 423, 10.1111/j.1440-1681.2011.05529.x Garjani, 2009, The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats, J Ethnopharmacol, 126, 525, 10.1016/j.jep.2009.09.003 Lamb, 1992, The effect of EDTA on the oxidation of low density lipoprotein, Atherosclerosis, 94, 35, 10.1016/0021-9150(92)90185-J Knudtson, 2002, Chelation therapy for ischemic heart disease, JAMA, 287, 481, 10.1001/jama.287.4.481 Demopoulos, 1983, The development of secondary pathology with free radical reactions as a threshold mechanism, Int J Toxicol, 2, 173, 10.3109/10915818309140700 Wang, 2011, Adiponectin inhibits hyperlipidemia-induced platelet aggregation via attenuating oxidative/nitrative stress, Physiol Res, 60, 347, 10.33549/physiolres.932044 Ferlito, 1999, Nitrite plasma levels in normolipemic and hypercholesterolemic patients with peripheral occlusive arteriopathy, Panminerva Med, 41, 307 Kanazawa, 1996, Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation, Am J Pathol, 148, 1949 Rahman, 2001, Paradoxical increase in nitric oxide synthase activity in hypercholesterolaemic rats with impaired renal function and decreased activity of nitric oxide, Nephrol Dial Transplant, 16, 262, 10.1093/ndt/16.2.262 Wu, 2009, Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet, J Ethnopharmacol, 122, 509, 10.1016/j.jep.2009.01.017 Laufs, 1998, Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors, Circulation, 97, 1129, 10.1161/01.CIR.97.12.1129 Foglieni, 2006, Protective effect of EDTA preadministration on renal ischemia, BMC Nephrol, 7, 5, 10.1186/1471-2369-7-5 Fisher, 2004, Superoxide and hydrogen peroxide suppression by metal ions and their EDTA complexes, Biochem Biophys Res Commun, 316, 48, 10.1016/j.bbrc.2004.02.013 Li, 2007, Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity, Am J Physiol Endocrinol Metab, 293, 1703, 10.1152/ajpendo.00462.2007 Anderson, 1997, Oxidative stress, endothelial function and coronary atherosclerosis, Cardiologia, 42, 701 Risher, 2005, Mercury exposure: evaluation and intervention the inappropriate use of chelating agents in the diagnosis and treatment of putative mercury poisoning, Neurotoxicology, 26, 691, 10.1016/j.neuro.2005.05.004 Attia, 2012, Protective effect of vitamin E and selenium on the liver, heart and aorta, J Vet Anat, 5, 17, 10.21608/jva.2012.44881 Steinberg, 1997, Oxidative modification of LDL and atherogenesis, Circulation, 95, 1062, 10.1161/01.CIR.95.4.1062 Meisinger, 2005, Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population, Circulation, 112, 651, 10.1161/CIRCULATIONAHA.104.529297 Lima, 2004, Statin-induced cholesterol lowering and plaque regression after 6months of magnetic resonance imaging–monitored therapy, Circulation, 110, 2336, 10.1161/01.CIR.0000145170.22652.51