Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis

Lasers in Surgery and Medicine - Tập 38 Số 7 - Trang 682-688 - 2006
Hana Tuby1, Lidya Maltz1, Uri Oron1
1Department of Zoology, The George S. Wise Faculty of Life Sciences Tel Aviv University, Tel Aviv 69978, Israel

Tóm tắt

AbstractBackground and ObjectivesIt has been shown previously that low‐level laser therapy (LLLT) significantly reduces infarct size following induction of myocardial infarction in rats and dogs. The aim of the present study was to investigate the effect of LLLT on the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS).Study Design and Material and MethodsMyocardial infarction was induced by occlusion of the left descending artery in 87 rats. LLLT was applied to intact and post‐infarction. VEGF, iNOS, and angiogenesis were determined.ResultsBoth the laser‐irradiated rat hearts post‐infarction and intact hearts demonstrated a significant increase in VEGF and iNOS expression compared to non‐laser‐irradiated hearts. LLLT also caused a significant elevation in angiogenesis.ConclusionsIt is concluded that VEGF and iNOS expression in the infarcted rat heart is markedly upregulated by LLLT and is associated with enhanced angiogenesis and cardioprotection. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.

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Lasers in Surgery and Medicine

Tập 38 Số 7

682-688

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