Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells

N. Calonghi1, E. Pagnotta1, C. Parolin1, C. Molinari1, C. Boga2, F. Dal Piaz3, G.L. Brusa4, M.A. Santucci4, L. Masotti1
1Department of Biochemistry “G. Moruzzi”, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
2Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, University of Bologna, Bologna, Italy
3CIRB, Alma Mater Studiorum, University of Bologna, Bologna, Italy
4Department of Hematology and Clinical Oncology “L.A. Seragnoli”, Alma Mater Studiorum, University of Bologna, Bologna, Italy

Tài liệu tham khảo

Gu, 1997, Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, 90, 595, 10.1016/S0092-8674(00)80521-8 Vogelstein, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675 Attardi, 2004, Conquering the complexity of p53, Nat. Genet., 36, 7, 10.1038/ng0104-7 Appella, 2001, Post-translational modifications and activation of p53 by genotoxic stresses, Eur. J. Biochem., 268, 2764, 10.1046/j.1432-1327.2001.02225.x Brooks, 2003, Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation, Curr. Opin. Cell Biol., 15, 164, 10.1016/S0955-0674(03)00003-6 Chuikov, 2004, Regulation of p53 activity through lysine methylation, Nature, 432, 353, 10.1038/nature03117 Sakaguchi, 1998, DNA damage activates p53 through a phosphorylation-acetylation cascade, Genes Dev., 12, 2831, 10.1101/gad.12.18.2831 Steegenga, 1996, How phosphorylation regulates the activity of p53, J. Mol. Biol., 263, 103, 10.1006/jmbi.1996.0560 Waterman, 1998, ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins, Nat. Genet., 19, 175, 10.1038/542 Xirodimas, 2004, Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity, Cell, 118, 83, 10.1016/j.cell.2004.06.016 Luo, 2004, Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo, Proc. Natl. Acad. Sci. U. S. A., 101, 2259, 10.1073/pnas.0308762101 Ito, 2001, p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2, EMBO J., 20, 1331, 10.1093/emboj/20.6.1331 Liu, 1999, p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage, Mol. Cell. Biol., 19, 1202, 10.1128/MCB.19.2.1202 Murphy, 1999, Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a, Genes Dev., 13, 2490, 10.1101/gad.13.19.2490 Luo, 2000, Deacetylation of p53 modulates its effect on cell growth and apoptosis, Nature, 408, 377, 10.1038/35042612 Juan, 2000, Histone deacetylases specifically down-regulate p53-dependent gene activation, J. Biol. Chem., 275, 20436, 10.1074/jbc.M000202200 Narlikar, 2002, Cooperation between complexes that regulate chromatin structure and transcription, Cell, 108, 475, 10.1016/S0092-8674(02)00654-2 Fischle, 2001, The emerging role of class II histone deacetylases, Biochem. Cell. Biol., 79, 337, 10.1139/o01-116 Calonghi, 2004, 9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cells, Biochem. Biophys. Res. Commun., 314, 138, 10.1016/j.bbrc.2003.12.066 Pagnotta, 2006, N-methylformamide and 9-hydroxystearic acid: two anti-proliferative and differentiating agents with different modes of action in colon cancer cells, Anti-cancer Drugs, 17, 521, 10.1097/00001813-200606000-00005 Calonghi, 2005, Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer, J. Lipid Res., 46, 1596, 10.1194/jlr.M400424-JLR200 Yamashita, 1990, Okadaic acid, a potent inhibitor of type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells, EMBO J., 9, 4331, 10.1002/j.1460-2075.1990.tb07882.x Zanella, 2002, Mitochondrial nitrix oxide localization in H9c2 cells revealed by confocal microscopy, Biochem. Biophys. Res. Commun., 290, 1010, 10.1006/bbrc.2001.6284 Shevchenko, 1996, Mass spectrometric sequencing of proteins from silver stained polyacrilamide gels, Anal. Chem., 68, 850, 10.1021/ac950914h Nome, 2005, Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death, Mol. Cancer Ther., 4, 1231, 10.1158/1535-7163.MCT-04-0304 Sharpless, 2002, p53: good cop/bad cop, Cell, 110, 9, 10.1016/S0092-8674(02)00818-8 Menendez, 2006, The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes, Mol. Cell. Biol., 26, 2297, 10.1128/MCB.26.6.2297-2308.2006 Castedo, 2004, Cell death by mitotic catastrophe: a molecular definition, Oncogene, 23, 2825, 10.1038/sj.onc.1207528