Modulation of 5-HT2A receptor-mediated head-twitch behaviour in the rat by 5-HT2C receptor agonists

Pharmacology Biochemistry and Behavior - Tập 69 - Trang 643-652 - 2001
S.P Vickers1, N Easton1, C.S Malcolm1, N.H Allen1, R.H Porter1, M.J Bickerdike1, G.A Kennett1
1Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK

Tài liệu tham khảo

Berendsen, 1990, Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice, Br J Pharmacol, 101, 667, 10.1111/j.1476-5381.1990.tb14138.x Boes, 1997, Novel agonists of 5-HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylamines. Improved therapeutics for obsessive compulsive disorder, J Med Chem, 40, 2762, 10.1021/jm970030l Britt, 1988, Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors, J Pharmacol Exp Ther, 247, 965 Colpaert, 1983, The head twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist, Neuropharmacology, 22, 993, 10.1016/0028-3908(83)90215-0 Conn, 1987, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT2 and 5-HT1C) receptors, J Pharmacol Exp Ther, 242, 552 Darmani, 1990, Do functional relationships exist between 5-HT1A and 5-HT2 receptors?, Pharmacol Biochem Behav, 36, 901, 10.1016/0091-3057(90)90098-3 Fone, 1998, Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat, Br J Pharmacol, 123, 1707, 10.1038/sj.bjp.0701798 Fozard, 1979, Metoclopramide antagonism of 5-hydroxyptophan-induced “wet dog” shake behaviour in the rat, Naunyn-Schmeideberg's Arch Pharmacol, 307, 135, 10.1007/BF00498455 Goodall, 1993, Ritanserin attenuates anorectic, endocrine and thermic responses to d-fenfluramine in human volunteers, Psychopharmacology, 112, 461, 10.1007/BF02244895 Kennett, 1993, 5-HT1C receptors and their therapeutic relevance, Curr Opin Invest Drugs, 2, 317 Kennett, 1988, Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors, Br J Pharmacol, 94, 137, 10.1111/j.1476-5381.1988.tb11508.x Kennett, 1988, Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors, Psychopharmacology, 96, 93, 10.1007/BF02431539 Kennett, 1989, Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia, Br J Pharmacol, 103, 2016, 10.1111/j.1476-5381.1991.tb12369.x Kennett, 1989, Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists, Eur J Pharmacol, 164, 445, 10.1016/0014-2999(89)90252-5 Kennett, 1997, BW723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats, Neuropharmacology, 36, 233, 10.1016/S0028-3908(96)00171-2 Kennett, 1997, SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist, Neuropharmacology, 36, 609, 10.1016/S0028-3908(97)00038-5 Kennett, 1998, Anxiolytic-like actions of BW723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated, Neuropharmacology, 37, 1603, 10.1016/S0028-3908(98)00115-4 Lucaites, 1996, Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily, Life Sci, 59, 1081, 10.1016/0024-3205(96)00423-7 Marek, 1996, LSD and the phenylethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex, J Pharmacol Exp Ther, 278, 1373 Martin, 1994, Receptors of 5-hydroxytryptamine: current perspectives on classification and nomenclature, Neuropharmacology, 33, 261, 10.1016/0028-3908(94)90058-2 Martin, 1998, 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential, J Pharmacol Exp Ther, 286, 913 Mennini, 1991, Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs, Naunyn-Schmeideberg's Arch Pharmacol, 343, 483, 10.1007/BF00169550 Neill, 1989, Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors, Psychopharmacology, 97, 213, 10.1007/BF00442252 Pierce, 1989, Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex, Psychopharmacology, 97, 118, 10.1007/BF00443425 Porter, 1999, Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells, Br J Pharmacol, 128, 13, 10.1038/sj.bjp.0702751 Pranzatelli, 1990, Evidence for involvement of 5-HT2 and 5-HT1C receptors in the behavioral effects of the 5-HT agonist 1-(2,5-dimethoxy-4-iodophenyl aminopropane)-2 (DOI), Neurosci Lett, 115, 74, 10.1016/0304-3940(90)90520-J Sargent, 1997, 5-HT2C receptor activation decreases appetite and body weight in obese subjects, Psychopharmacology, 133, 309, 10.1007/s002130050407 Schreiber, 1995, (1-(2,5-Dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT2A) receptors: modulation by novel 5-HT2A/2C receptor antagonists, D1 antagonists and 5-HT1A agonists, J Pharmacol Exp Ther, 273, 101 Titeler, 1988, Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens, Psychopharmacology, 94, 213, 10.1007/BF00176847 Vickers, 1999, Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice, Psychopharmacology, 143, 309, 10.1007/s002130050952 Vickers, 2000, Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats, Br J Pharmacol, 130, 1305, 10.1038/sj.bjp.0703443 Vickers, 2000, Interaction of 5-HT2A and 5-HT2C receptors in the mediation of head shake behaviour in rats, Br J Pharmacol, 129, 152P Willins, 1997, Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head twitch response in rats, J Pharmacol Exp Ther, 282, 699