Modulating effects of preconditioning exercise in the expression of ET-1 and BNP via HIF-1α in ischemically injured brain
Tóm tắt
It is well-known that in ischemia-induced hypoxia, hypoxia-inducible factor -1α (HIF-1α) is critical in triggering expression of its downstream target genes to produce several products, such as erythropoietin (EPO), vascular endothelial growth factor (VEGF), nitric oxide synthesis (NOS), glucose transportor-1 (GLUT-1), insulin-like growth factor (IGF), which further promote erythropoiesis, angiogenesis, vasodilation and capitalization of glucose to overcome hypoxia. Meanwhile, as the factors with opposite effects on blood vessels, endothelin-1 (ET-1) and brain natriuretic peptide (BNP) also stand out strikingly in ischemic pathophysiology. To this day, several preconditioning manners have been used to induce tolerance to ischemia. During our research, exercise preconditioning was applied and it was demonstrated that HIF-1α triggered expression of ET-1 and BNP, which confirmed their downstream target genes for HIF-1α. And ET-1 may influcence expression of BNP to some degree but not the only factor which regulates BNP expression. Therefore, our findings suggest exercise preconditioning may provide protection to the ischemic brain tissue via HIF-1α which in turn increases expression of BNP to cause vasodilation in cooperation with some other factors, such as VEGF and EPO, to increase the blood flow in the ischemic area and then relieve the injuries induced by ischemia.
Tài liệu tham khảo
Aboutaleb N, Shamsaei N, Khaksari M, Erfani S, Rajabi H, Nikbakht F (2015) Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation. J Physiol Sci 65:435–443
Aburaya M, Suzuki E, Minamino N, Kangawa K, Tanaka K, Matsuo H (1991) Concentration and molecular forms of brain natriuretic peptide in rat plasma and spinal cord. Biochem Biophys Res Commun 177:40–47
Alioglu Z, Orem A, Bulbul I, Boz C, Ozmenoglu M, Vanizor B (2002) Evaluation of plasma endothelin-1 levels in patients with cerebral infarction. Angiology 53:77–82
Barone FC, Globus MY, Price WJ, White RF, Storer BL, Feuerstein GZ, Busto R, Ohlstein EH (1994) Endothelin levels increase in rat focal and global ischemia. J Cereb Blood Flow Metab 14:337–342
Bernaudin M, Nedelec AS, Divoux D, MacKenzie ET, Petit E, Schumann-Bard P (2002) Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J Cereb Blood Flow Metab 22:393–403
Bhalla S, Leonard MG, Briyal S, Gulati A (2016) Distinct alteration in brain Endothelin a and B receptor characteristics following focal cerebral ischemia in rats. Drug Res (Stuttg) 66:189–195
Bruneau BG, Piazza LA, Bold AJ, De %J am J Physiol (1997), BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria Heart and circulatory physiology 273:2678–2686
Chawla S, Rahar B, Singh M, Bansal A, Saraswat D, Saxena S (2014) Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. PLoS One 9:e98025
Cheng G, Yu WH, Yan C, Liu Y, Li WJ, Zhang DD, Liu N (2016) Nuclear factor-κB is involved in oxyhemoglobin-induced endothelin-1 expression in cerebrovascular muscle cells of the rabbit basilar artery. NeuroReport 27:875–882
Chrysohoou C, Pitsavos C, Kokkinos P, Panagiotakos DB, Singh SN, Stefanadis C (2005) The role of physical activity in the prevention of stroke. Cent Eur J Public Health 13:132–136
Curry A, Guo M, Patel R, Liebelt B, Sprague S, Lai Q, Zwagerman N, Cao FX, Jimenez D, Ding Y (2010) Exercise pre-conditioning reduces brain inflammation in stroke via tumor necrosis factor-alpha, extracellular signal-regulated kinase 1/2 and matrix metalloproteinase-9 activity. Neurol Res 32:756–762
Ding YH, Ding Y, Li J, Bessert DA, Rafols JA (2006a) Exercise pre-conditioning strengthens brain microvascular integrity in a rat stroke model. Neurol Res 28:184–189
Ding YH, Li J, Yao WX, Rafols JA, Clark JC, Ding Y (2006b) Exercise preconditioning upregulates cerebral integrins and enhances cerebrovascular integrity in ischemic rats. Acta Neuropathol 112:74–84
Gras E, Arnaud C, Briancon-Marjollet A, Levy P, Godin-Ribuot DJF, Pharmacology C (2012) Involvement of the HIF-1 transcription factor and of endothelin-1 in systemic inflammation and vascular remodelling induced by chronic intermittent hypoxia. Fundam Clin Pharmacol 26:19–19
Hu J, Discher DJ, Bishopric NH, Webster KA (1998) Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 245:894–899
Iltumur K, Yavavli A, Apak I, Ariturk Z, Toprak N (2006) Elevated plasma N-terminal pro-brain natriuretic peptide levels in acute ischemic stroke. Am Heart J 151:1115–1122
James ML, Blessing R, Phillips-Bute BG, Bennett E, Laskowitz DT (2009) S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers 14:388–394
Jamison JT, Lewis MK, Kreipke CW, Rafols JA, DeGracia DJ (2011) Polyadenylated mRNA staining reveals distinct neuronal phenotypes following endothelin 1, focal brain ischemia, and global brain ischemia/ reperfusion. Neurol Res 33:145–161
Jiang C, Wang J, Li X, Liu C, Chen N, Hao Y (2009) Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke. Inflamm Res 58:619–624
Kaelin WG Jr, Ratcliffe PJ (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30:393–402
Kakinuma Y, Miyauchi T, Suzuki T, Yuki K, Murakoshi N, Goto K, Yamaguchi I (2002), Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha. Clinical science (London, England : 1979) 103 Suppl 48:210s–214s
Kang KA, Seong H, Jin HB, Park J, Lee J, Jeon JY, Kim YJ (2011) The effect of treadmill exercise on ischemic neuronal injury in the stroke animal model: potentiation of cerebral vascular integrity. J Korean Acad Nurs 41:197–203
Kreipke CW, Schafer PC, Rossi NF, Rafols JA (2010) Differential effects of endothelin receptor a and B antagonism on cerebral hypoperfusion following traumatic brain injury. Neurol Res 32:209–214
Kuwahara K, Saito Y, Ogawa Y, Tamura N, Ishikawa M, Harada M, Ogawa E, Miyamoto Y, Hamanaka I, Kamitani S, Kajiyama N, Takahashi N, Nakagawa O, Masuda I, Nakao K (1998) Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms. J Cardiovasc Pharmacol 31(Suppl 1):S354–S356
Lee CD, Folsom AR, Blair SN (2003) Physical activity and stroke risk: a meta-analysis. Stroke 34:2475–2481
Li Y, Xia ZL, Chen LB (2011) HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats. Neurol Res 33:583–592
Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84–91
Lu X, Kang Y (2010) Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 16:5928–5935
Lu L, Li HQ, Li JH, Liu AJ, Zheng GQ (2015) Neuroprotection of Sanhua decoction against focal cerebral ischemia/reperfusion injury in rats through a mechanism targeting aquaporin 4. Evid Based Complement Alternat Med 2015:584245
Maack T (2006) The broad homeostatic role of natriuretic peptides. Arq Bras Endocrinol Metabol 50:198–207
Makikallio AM, Makikallio TH, Korpelainen JT, Vuolteenaho O, Tapanainen JM, Ylitalo K, Sotaniemi KA, Huikuri HV, Myllyla VV (2005) Natriuretic peptides and mortality after stroke. Stroke 36:1016–1020
Masada T, Hua Y, Xi G, Ennis SR, Keep RF (2001) Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat. J Cereb Blood Flow Metab 21:22–33
Matsuda T, Abe T, Wu JL, Fujiki M, Kobayashi H (2005) Hypoxia-inducible factor-1alpha DNA induced angiogenesis in a rat cerebral ischemia model. Neurol Res 27:503–508
McGirt MJ, Blessing R, Nimjee SM, Friedman AH, Alexander MJ, Laskowitz DT, Lynch JR (2004) Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage. Neurosurgery 54:1369–1373; discussion 1373-1364
Minchenko A, Caro J (2000) Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsive element. Mol Cell Biochem 208:53–62
Ogle ME, Gu X, Espinera AR, Wei L (2012) Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1alpha. Neurobiol Dis 45:733–742
Robitaille GA, Larivière R, Richard DEJCP (2004) Activation of endothelin-1 production by TGF-beta1 in endothelial cells: implication of the hypoxia-inducible transcription factor HIF-1. J Hypertens 13:141–141
Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447–5454
Stetler RA, Leak RK, Gan Y, Li P, Zhang F, Hu X, Jing Z, Chen J, Zigmond MJ, Gao Y (2014) Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol 114:58–83
Tomita H, Metoki N, Saitoh G, Ashitate T, Echizen T, Katoh C, Fukuda M, Yasujima M, Osanai T, Okumura K (2008) Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity. Hypertens Res 31:1695–1702
van der Zander K, Houben AJ, Kroon AA, De Mey JG, Smits PA, de Leeuw PW (2002) Nitric oxide and potassium channels are involved in brain natriuretic peptide induced vasodilatation in man. J Hypertens 20:493–499
Wacker BK, Perfater JL, Gidday JM (2012) Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. J Neurochem 123:954–962
Wang L, Deng W, Yuan Q, Yang H (2015) Exercise preconditioning reduces ischemia reperfusion-induced focal cerebral infarct volume through up-regulating the expression of HIF-1alpha. Pak J Pharm Sci 28:791–798
Wilhide ME, Jones WK (2006) Potential therapeutic gene for the treatment of ischemic disease: Ad2/hypoxia-inducible factor-1alpha (HIF-1)/VP16 enhances B-type natriuretic peptide gene expression via a HIF-1-responsive element. Mol Pharmacol 69:1773–1778
Wu C, Hu Q, Chen J, Yan F, Li J, Wang L, Mo H, Gu C, Zhang P, Chen GJBBRC (2013) Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats. Biochem Biophys Res Commun 437:469–474
Yeh SH, Ou LC, Gean PW, Hung JJ, Chang WC (2011) Selective inhibition of early--but not late--expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage. Brain Pathol 21:249–262
Young W, Rappaport ZH, Chalif DJ, Flamm ES (1987) Regional brain sodium, potassium, and water changes in the rat middle cerebral artery occlusion model of ischemia. Stroke 18:751–759
Zagorska A, Dulak J (2004) HIF-1: the knowns and unknowns of hypoxia sensing. Acta Biochim Pol 51:563–585
Zhang R, Xue YY, Lu SD, Wang Y, Zhang LM, Huang YL, Signore AP, Chen J, Sun FY (2006) Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion. Neurobiol Dis 24:345–356
Zhang F, Wu Y, Jia J (2011) Exercise preconditioning and brain ischemic tolerance. Neuroscience 177:170–176
Zhang Q, Zhang L, Yang X, Wan Y, Jia J (2014) The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats. J Stroke Cerebrovasc Dis 23:1696–1702
Zhao X, Wu T, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J (2015) Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun 46:293–310
Zhou F, Guo J, Cheng J, Wu G, Xia Y (2011) Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency. J Appl Physiol (1985) 111:1877–1887