Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma

Schwabe, 2020, Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis, Gastroenterology, 158, 1913, 10.1053/j.gastro.2019.11.311 Buzzetti, 2016, The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD), Metabolism, 65, 1038, 10.1016/j.metabol.2015.12.012 Negro, 2020, Natural history of NASH and HCC, Liver Int., 40, 72, 10.1111/liv.14362 Dhamija, 2019, Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: An increasing concern, Indian J. Med. Res., 149, 9, 10.4103/ijmr.IJMR_1456_17 Febbraio, 2019, Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?, Cell Metab., 29, 18, 10.1016/j.cmet.2018.10.012 Ma, 2018, Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes, FEBS J., 285, 752, 10.1111/febs.14209 Chen, 2020, Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, Free Radic. Biol. Med., 152, 116, 10.1016/j.freeradbiomed.2020.02.025 Sakurai, 2008, Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis, Cancer Cell, 14, 156, 10.1016/j.ccr.2008.06.016 Farber, 1991, Hepatocyte proliferation in stepwise development of experimental liver cell cancer, Dig. Dis. Sci., 36, 973, 10.1007/BF01297150 Hall, 2021, Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma, Hepatology, 73, 1028, 10.1002/hep.31391 Peck, 2016, Lipid desaturation - the next step in targeting lipogenesis in cancer?, FEBS J., 283, 2767, 10.1111/febs.13681 Peck, 2016, Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments, Cancer Metab., 4, 10.1186/s40170-016-0146-8 Younossi, 2019, Nonalcoholic Steatohepatitis Is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates, Clin. Gastroenterol Hepatol., 17, 748, 10.1016/j.cgh.2018.05.057 Fujii, 2013, A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma, Med. Mol. Morphol., 46, 141, 10.1007/s00795-013-0016-1 Abdollahi, 2014, Streptozotocin, 402 Szkudelski, 2001, The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas, Physiol. Res., 50, 537 Schnedl, 1994, STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells, Diabetes, 43, 1326, 10.2337/diab.43.11.1326 Fujimoto, 2011, IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice, Am. J. Clin. Pathol., 179, 2327, 10.1016/j.ajpath.2011.08.001 Takeda, 2012, Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice, Diabetologia, 55, 404, 10.1007/s00125-011-2365-4 Bennett, 1981, Alkylation of DNA in rat tissues following administration of streptozotocin, Cancer Res., 41, 2786 Morgan, 1994, Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis, Biosci. Rep., 14, 243, 10.1007/BF01209729 Kröncke, 1995, Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage, Bio. Chem. Hoppe-Seyler, 376, 179, 10.1515/bchm3.1995.376.3.179 West, 1996, Streptozotocin alters pancreatic beta-cell responsiveness to glucose within six hours of injection into rats, The West Indian Med. J., 45, 60 Portha, 1974, Diabetogenic effect of streptozotocin in the rat during the perinatal period, Diabetes, 23, 889, 10.2337/diab.23.11.889 Giroix, 1983, Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas, Diabetes, 32, 445, 10.2337/diab.32.5.445 Sasaki, 2020, Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content, Sci. Rep., 10, 7818, 10.1038/s41598-020-64902-8 Saito, 2017, Pathophysiological analysis of the progression of hepatic lesions in STAM mice, Physiol. Res, 66, 791, 10.33549/physiolres.933592 Iida, 2019, Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice, Exp. Anim., 68, 417, 10.1538/expanim.18-0152 van der Windt, 2018, Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis, Hepatology, 68, 1347, 10.1002/hep.29914 Eklund, 2012, Immune functions of serum amyloid A, Crit. Rev. Immunol., 32, 335, 10.1615/CritRevImmunol.v32.i4.40 Wang, 2008, Immunohistochemistry in the evaluation of neovascularization in tumor xenografts, Biotech. Histochem., 83, 179, 10.1080/10520290802451085 Chen, 2019, HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway, Aging, 11, 10839, 10.18632/aging.102488 Fishman, 2019, The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice, Int. J. Mol. Med., 44, 2256 Takaki, 2014, Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis, Cancer Sci., 105, 1254, 10.1111/cas.12498 Fekry, 2019, HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma, Cancer Res., 79, 5860, 10.1158/0008-5472.CAN-19-1277 Middleton, 2018, BET Inhibition Improves NASH and Liver Fibrosis, Sci. Rep., 8, 17257, 10.1038/s41598-018-35653-4 Hansen, 2017, Mouse models of nonalcoholic steatohepatitis in preclinical drug development, Drug Discov., 22, 1707 Farrell, 2019, Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis, Hepatology, 69, 2241, 10.1002/hep.30333 Wang, 2009, Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats, Int. J. Cancer, 124, 540, 10.1002/ijc.23995 Verna, 1996, N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation, Pharmacol. Ther., 71, 57, 10.1016/0163-7258(96)00062-9 Lafaro, 2015, Epidemiology of hepatocellular carcinoma, Surg. Oncol. Clin. N. Am., 24, 1, 10.1016/j.soc.2014.09.001 Pollack, 2003, Environmental persistence of chemicals and their carcinogenic risks to humans, Mutat. Res., 528, 81, 10.1016/S0027-5107(03)00097-6 Connor, 2018, Mutational landscape of a chemically-induced mouse model of liver cancer, J. Hepatol., 69, 840, 10.1016/j.jhep.2018.06.009 Lieber, 2004, Model of nonalcoholic steatohepatitis, Am. J. Clin. Nutr., 79, 502, 10.1093/ajcn/79.3.502 Fu, 2020, High-Fat Diet Promotes Macrophage-Mediated Hepatic Inflammation and Aggravates Diethylnitrosamine-Induced Hepatocarcinogenesis in Mice, Front. Nutr., 7 Li, 2003, p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2, Cancer Res., 63, 3473 Iyoda, 2003, Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma, Cancer, 97, 3017, 10.1002/cncr.11425 Arboatti, 2019, Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd), Chem. Biol. Interact., 303, 70, 10.1016/j.cbi.2019.02.024 Duan, 2014, High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma, BMC Gastroenterol., 14, 195, 10.1186/s12876-014-0195-9 Lee, 2004, Application of comparative functional genomics to identify best-fit mouse models to study human cancer, Nat. Genet., 36, 1306, 10.1038/ng1481 Calvisi, 2006, Ubiquitous activation of Ras and Jak/Stat pathways in human HCC, Gastroenterology, 130, 1117, 10.1053/j.gastro.2006.01.006 Kishida, 2016, Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine, BMC Gastroenterol., 16, 61, 10.1186/s12876-016-0477-5 Lin, 2014, Chapter 2.3-The Biochemistry of Choline, 104 Penry, 2008, Choline: an important micronutrient for maximal endurance-exercise performance?, Int. J Sport Nutr. Exerc. Metab., 18, 191, 10.1123/ijsnem.18.2.191 Yao, 1988, The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes, J. Biol. Chem., 263, 2998, 10.1016/S0021-9258(18)69166-5 de Oliveira, 2006, Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats, World J Gastroenterol., 12, 1905, 10.3748/wjg.v12.i12.1905 Oliveira, 2006, Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease, Braz. J Med. Biol. Res., 39, 189, 10.1590/S0100-879X2006000200004 de Lima, 2008, A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma, J. Hepatol., 49, 1055, 10.1016/j.jhep.2008.07.024 Oliveira, 2002, Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet, J. Cell. Mol. Med., 6, 399, 10.1111/j.1582-4934.2002.tb00518.x Tsuchida, 2018, A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer, J. Hepatol., 69, 385, 10.1016/j.jhep.2018.03.011 Zhang, 2020, Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose (WDF), BMC Gastroenterol., 20, 339, 10.1186/s12876-020-01467-w Scholten, 2015, The carbon tetrachloride model in mice, Lab. Anim., 49, 4, 10.1177/0023677215571192 Carter, 2021, Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales, PLoS One, 16, e0244763, 10.1371/journal.pone.0244763 G. Zhang, X. Wang, T.-Y. Chung, W. Ye, L. Hodge, L. Zhang, K. Chng, Y.-F. Xiao, Y.J. Wang, Carbon tetrachloride (CCl(4)) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose (WDF), BMC Gastroenterol. 20 (1) (2020) 339-339. Asakawa, 2019, Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis, Sci. Rep., 9, 19601, 10.1038/s41598-019-56039-0