Modeling Cancer with Pluripotent Stem Cells

Thomson, 1998, Embryonic stem cell lines derived from human blastocysts, Science, 282, 1145, 10.1126/science.282.5391.1145

Takahashi, 2006, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 126, 663, 10.1016/j.cell.2006.07.024

Takahashi, 2007, Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell, 131, 861, 10.1016/j.cell.2007.11.019

Yu, 2007, Induced pluripotent stem cell lines derived from human somatic cells, Science, 318, 1917, 10.1126/science.1151526

González, 2011, Methods for making induced pluripotent stem cells: reprogramming à la carte, Nat. Rev. Genet., 12, 231, 10.1038/nrg2937

Murry, 2008, Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development, Cell, 132, 661, 10.1016/j.cell.2008.02.008

Lancaster, 2014, Organogenesis in a dish: modeling development and disease using organoid technologies, Science, 345, 1247125, 10.1126/science.1247125

Yin, 2016, Engineering stem cell organoids, Cell Stem Cell, 18, 25, 10.1016/j.stem.2015.12.005

Grskovic, 2011, Induced pluripotent stem cells – opportunities for disease modelling and drug discovery, Nat. Rev. Drug Discov., 10, 915, 10.1038/nrd3577

Dimos, 2008, Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons, Science, 321, 1218, 10.1126/science.1158799

Park, 2008, Disease-specific induced pluripotent stem cells, Cell, 134, 877, 10.1016/j.cell.2008.07.041

Yagi, 2011, Modeling familial Alzheimer's disease with induced pluripotent stem cells, Hum. Mol. Genet., 20, 4530, 10.1093/hmg/ddr394

Brennand, 2011, Modelling schizophrenia using human induced pluripotent stem cells, Nature, 473, 221, 10.1038/nature09915

Carvajal-Vergara, 2010, Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome, Nature, 465, 808, 10.1038/nature09005

Pasca, 2011, Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome, Nat. Med., 17, 1657, 10.1038/nm.2576

Itzhaki, 2011, Modelling the long QT syndrome with induced pluripotent stem cells, Nature, 471, 225, 10.1038/nature09747

Moretti, 2010, Patient-specific induced pluripotent stem-cell models for long-QT syndrome, N. Engl. J. Med., 363, 1397, 10.1056/NEJMoa0908679

Rashid, 2010, Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells, J. Clin. Invest., 120, 3127, 10.1172/JCI43122

Liu, 2011, Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs, Cell Stem Cell, 8, 688, 10.1016/j.stem.2011.04.019

Smith-Arica, 2003, Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors, Cloning Stem Cells, 5, 51, 10.1089/153623003321512166

Ivanova, 2006, Dissecting self-renewal in stem cells with RNA interference, Nature, 442, 533, 10.1038/nature04915

Lee, 2012, Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling, Cell Stem Cell, 11, 179, 10.1016/j.stem.2012.05.020

Yusa, 2011, Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells, Nature, 478, 391, 10.1038/nature10424

Zou, 2009, Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells, Cell Stem Cell, 5, 97, 10.1016/j.stem.2009.05.023

Hockemeyer, 2009, Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases, Nat. Biotechnol., 27, 851, 10.1038/nbt.1562

Luo, 2014, Generation of GFP reporter human induced pluripotent stem cells using AAVS1 safe harbor transcription activator-like effector nuclease, Curr. Protoc. Stem Cell Biol., 29, 10.1002/9780470151808.sc05a07s29

Ding, 2013, A TALEN genome-editing system for generating human stem cell-based disease models, Cell Stem Cell, 12, 238, 10.1016/j.stem.2012.11.011

Mali, 2013, RNA-guided human genome engineering via Cas9, Science, 339, 823, 10.1126/science.1232033

Cong, 2013, Multiplex genome engineering using CRISPR/Cas systems, Science, 339, 819, 10.1126/science.1231143

Lee, 2015, Modeling familial cancer with induced pluripotent stem cells, Cell, 161, 240, 10.1016/j.cell.2015.02.045

Mulero-Navarro, 2015, Myeloid dysregulation in a human induced pluripotent stem cell model of PTPN11-associated juvenile myelomonocytic leukemia, Cell Rep., 13, 504, 10.1016/j.celrep.2015.09.019

Kotini, 2015, Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells, Nat. Biotechnol., 33, 646, 10.1038/nbt.3178

Funato, 2014, Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation, Science, 346, 1529, 10.1126/science.1253799

Duan, 2015, PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype, Nat. Commun., 6, 10068, 10.1038/ncomms10068

Li, 1988, A cancer family syndrome in twenty-four kindreds, Cancer Res., 48, 5358

Dugimont, 1998, The H19 TATA-less promoter is efficiently repressed by wild-type tumor suppressor gene product p53, Oncogene, 16, 2395, 10.1038/sj.onc.1201742

Roberts, 2013, Noonan syndrome, Lancet, 381, 333, 10.1016/S0140-6736(12)61023-X

Lindsley, 2013, Molecular pathophysiology of myelodysplastic syndromes, Annu. Rev. Pathol., 8, 21, 10.1146/annurev-pathol-011811-132436

Wu, 2012, Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas, Nat. Genet., 44, 251, 10.1038/ng.1102

Schwartzentruber, 2012, Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma, Nature, 482, 226, 10.1038/nature10833

Furnari, 2007, Malignant astrocytic glioma: genetics, biology, and paths to treatment, Genes Dev., 21, 2683, 10.1101/gad.1596707

Si-Tayeb, 2010, Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells, Hepatology, 51, 297, 10.1002/hep.23354

Goldman, 2013, KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development, Cell Stem Cell, 12, 748, 10.1016/j.stem.2013.04.026

Hannan, 2013, Production of hepatocyte-like cells from human pluripotent stem cells, Nat. Protoc., 8, 430, 10.1038/nprot.2012.153

Spence, 2011, Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro, Nature, 470, 105, 10.1038/nature09691

Antonica, 2012, Generation of functional thyroid from embryonic stem cells, Nature, 491, 66, 10.1038/nature11525

Dye, 2015, In vitro generation of human pluripotent stem cell derived lung organoids, Elife, 4, e05098, 10.7554/eLife.05098

Huang, 2014, Efficient generation of lung and airway epithelial cells from human pluripotent stem cells, Nat. Biotechnol., 32, 84, 10.1038/nbt.2754

Huang, 2015, The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells, Nat. Protoc., 10, 413, 10.1038/nprot.2015.023

Xia, 2013, Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells, Nat. Cell. Biol., 15, 1507, 10.1038/ncb2872

Takasato, 2014, Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney, Nat. Cell Biol., 16, 118, 10.1038/ncb2894

Osakada, 2009, Stepwise differentiation of pluripotent stem cells into retinal cells, Nat. Protoc., 4, 811, 10.1038/nprot.2009.51

Nakano, 2012, Self-formation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, 10, 771, 10.1016/j.stem.2012.05.009

Mellough, 2012, Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells, Stem Cells, 30, 673, 10.1002/stem.1037

Lamba, 2006, Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc. Natl. Acad. Sci. U.S.A., 103, 12769, 10.1073/pnas.0601990103

Yang, 2014, Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells, Nat. Commun., 5, 3071, 10.1038/ncomms4071

Kidwai, 2014, Differentiation of epidermal keratinocytes from human embryonic stem cells, Methods Mol. Biol., 1195, 13, 10.1007/7651_2013_46

Grigoriadis, 2010, Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells, Blood, 115, 2769, 10.1182/blood-2009-07-234690

Kennedy, 2007, Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures, Blood, 109, 2679, 10.1182/blood-2006-09-047704

Chambers, 2009, Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling, Nat. Biotechnol., 27, 275, 10.1038/nbt.1529

Lian, 2007, Derivation of clinically compliant MSCs from CD105+, CD24– differentiated human ESCs, Stem Cells, 25, 425, 10.1634/stemcells.2006-0420

Fang, 2006, Defining the conditions for the generation of melanocytes from human embryonic stem cells, Stem Cells, 24, 1668, 10.1634/stemcells.2005-0414

Lancaster, 2013, Cerebral organoids model human brain development and microcephaly, Nature, 501, 373, 10.1038/nature12517

McCracken, 2014, Modelling human development and disease in pluripotent stem-cell-derived gastric organoids, Nature, 516, 400, 10.1038/nature13863

Matano, 2015, Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids, Nat. Med., 21, 256, 10.1038/nm.3802

Takebe, 2013, Vascularized and functional human liver from an iPSC-derived organ bud transplant, Nature, 499, 481, 10.1038/nature12271

Takebe, 2014, Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant, Nat. Protoc., 9, 396, 10.1038/nprot.2014.020

Boj, 2015, Organoid models of human and mouse ductal pancreatic cancer, Cell, 160, 324, 10.1016/j.cell.2014.12.021

Xia, 2014, The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells, Nat. Protoc., 9, 2693, 10.1038/nprot.2014.182

Freedman, 2015, Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids, Nat. Commun., 6, 8715, 10.1038/ncomms9715

Morizane, 2015, Nephron organoids derived from human pluripotent stem cells model kidney development and injury, Nat. Biotechnol., 33, 1193, 10.1038/nbt.3392

Takasato, 2015, Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis, Nature, 526, 564, 10.1038/nature15695

Eiraku, 2011, Self-organizing optic-cup morphogenesis in three-dimensional culture, Nature, 472, 51, 10.1038/nature09941

Völkner, 2016, Retinal organoids from pluripotent stem cells efficiently recapitulate retinogenesis, Stem Cell Reports, 6, 525, 10.1016/j.stemcr.2016.03.001

Kuwahara, 2015, Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue, Nat. Commun., 6, 6286, 10.1038/ncomms7286

Rouhani, 2016, Mutational history of a human cell lineage from somatic to induced pluripotent stem cells, PLoS Genet., 12, e1005932, 10.1371/journal.pgen.1005932

Somers, 2010, Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette, Stem Cells, 28, 1728, 10.1002/stem.495

Fukawatase, 2014, Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability, Sci. Rep., 4, 5421, 10.1038/srep05421

Garçon, 2013, Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients, Blood, 122, 912, 10.1182/blood-2013-01-478321

Ge, 2015, Dysregulation of the transforming growth factor β pathway in induced pluripotent stem cells generated from patients with Diamond Blackfan anemia, PLoS ONE, 10, e0134878, 10.1371/journal.pone.0134878

Li, 2012, Trisomy correction in Down syndrome induced pluripotent stem cells, Cell Stem Cell, 11, 615, 10.1016/j.stem.2012.08.004

Agarwal, 2010, Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients, Nature, 464, 292, 10.1038/nature08792

Batista, 2011, Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells, Nature, 474, 399, 10.1038/nature10084

Itoh, 2011, Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells, Proc. Natl. Acad. Sci. U.S.A., 108, 8797, 10.1073/pnas.1100332108

Tolar, 2011, Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa, J. Invest. Dermatol., 131, 848, 10.1038/jid.2010.346

Raya, 2009, Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells, Nature, 460, 53, 10.1038/nature08129

Ye, 2009, Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders, Blood, 114, 5473, 10.1182/blood-2009-04-217406

Tulpule, 2013, Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction, Cell Stem Cell, 12, 727, 10.1016/j.stem.2013.04.002

Cheung, 2014, Telomerase protects werner syndrome lineage-specific stem cells from premature aging, Stem Cell Reports, 2, 534, 10.1016/j.stemcr.2014.02.006

Shimamoto, 2014, Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture, PLoS ONE, 9, e112900, 10.1371/journal.pone.0112900

Thatava, 2011, Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation, Stem Cell Res. Ther., 2, 48, 10.1186/scrt89

Komor, 2016, Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage, Nature, 533, 420, 10.1038/nature17946

Menon, 2015, Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs, Cell Stem Cell, 16, 367, 10.1016/j.stem.2015.02.005

Xie, 2014, Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac, Genome. Res., 24, 1526, 10.1101/gr.173427.114

Bellin, 2013, Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome, EMBO J., 32, 3161, 10.1038/emboj.2013.240