Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria

Mitochondrion - Tập 5 Số 5 - Trang 352-358 - 2005
Gerard G. M. D’Souza1, Sarathi V. Boddapati, Volkmar Weissig
1Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, 360 Huntington Avenue, 211 Mugar Building, Boston, MA 02115, USA.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Chinnery, 1999, Peptide nucleic acid delivery to human mitochondria, Gene Ther., 6, 1919, 10.1038/sj.gt.3301061

D'Souza, 2004, Approaches to mitochondrial gene therapy, Curr. Gene Ther., 4, 317, 10.2174/1566523043346200

D'Souza, 2003, DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells, J. Control Release, 92, 189, 10.1016/S0168-3659(03)00297-9

Flierl, 2003, Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid, Mol. Ther., 7, 550, 10.1016/S1525-0016(03)00037-6

Geromel, 2001, Mitochondria transfection by oligonucleotides containing a signal peptide and vectorized by cationic liposomes, Antisense Nucleic Acid Drug Dev., 11, 175, 10.1089/108729001300338708

Larson, 1999, Revolution in mitochondrial medicine, FEBS Lett., 455, 199, 10.1016/S0014-5793(99)00854-6

Lasch, 1999, Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack, Biol. Chem., 380, 647, 10.1515/BC.1999.080

Morin, 2001, Mitochondria as target for antiischemic drugs, Adv. Drug Deliv. Rev., 49, 151, 10.1016/S0169-409X(01)00132-6

Murphy, 2000, Drug delivery to mitochondria: the key to mitochondrial medicine, Adv. Drug Deliv. Rev., 41, 235, 10.1016/S0169-409X(99)00069-1

Schon, 2003, Medicinal and genetic approaches to the treatment of mitochondrial disease, Curr. Med. Chem., 10, 2523, 10.2174/0929867033456503

Singh, 2000, Mitochondrial me and the Mitochondrion journal, Mitochondrion, 1, 1, 10.1016/S1567-7249(00)00003-9

Weissig, 1998, DQAsomes: a novel potential drug and gene delivery system made from Dequalinium, Pharm. Res., 15, 334, 10.1023/A:1011991307631

Weissig, 2000, Selective DNA release from DQAsome/DNA complexes at mitochondria-like membranes, Drug Deliv., 7, 1, 10.1080/107175400266722

Weissig, 2001, DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria, J. Control Release, 75, 401, 10.1016/S0168-3659(01)00392-3

Weissig, 2001, DNA binding cationic bolasomes with delocalized charge center. A structure-activity relationship study, S.T.P. Pharma. Sci., 11, 91

Zelphati, 1999, Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA, Hum. Gene Ther., 10, 15, 10.1089/10430349950019156

Zelphati, 2000, PNA-dependent gene chemistry: stable coupling of peptides and oligonucleotides to plasmid DNA, Biotechniques, 28, 304, 10.2144/00282rr01