Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

Genes and Diseases - Tập 3 - Trang 82-87 - 2016
Baozhong Zhao1, Lei Qiang1, Joy Joseph2, Balaraman Kalyanaraman2, Benoit Viollet3, Yu-Ying He1
1Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA
2Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
3INSERM U567, CNRS UMR8104, Department of Endocrinology, Metabolism and Cancer, Institut Cochin, Université Paris 5, 75014 Paris, France

Tài liệu tham khảo

Klionsky, 2007, Autophagy: from phenomenology to molecular understanding in less than a decade, Nat Rev Mol Cell Biol, 8, 931, 10.1038/nrm2245 Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639 Choi, 2013, Autophagy in human health and disease, N Engl J Med, 368, 1845, 10.1056/NEJMra1205406 White, 2012, Deconvoluting the context-dependent role for autophagy in cancer, Nat Rev Cancer, 12, 401, 10.1038/nrc3262 Kroemer, 2010, Autophagy and the integrated stress response, Mol Cell, 40, 280, 10.1016/j.molcel.2010.09.023 Bossy-Wetzel, 2003, Mitochondrial fission in apoptosis, neurodegeneration and aging, Curr Opin Cell Biol, 15, 706, 10.1016/j.ceb.2003.10.015 Lin, 2006, Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases, Nature, 443, 787, 10.1038/nature05292 Lowell, 2005, Mitochondrial dysfunction and type 2 diabetes, Science, 307, 384, 10.1126/science.1104343 Brandon, 2006, Mitochondrial mutations in cancer, Oncogene, 25, 4647, 10.1038/sj.onc.1209607 Youle, 2011, Mechanisms of mitophagy, Nat Rev Mol Cell Biol, 12, 9, 10.1038/nrm3028 Bess, 2012, Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans, Nucleic Acids Res, 40, 7916, 10.1093/nar/gks532 Laderoute, 2006, 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments, Mol Cell Biol, 26, 5336, 10.1128/MCB.00166-06 Weinberg, 2010, Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity, Proc Natl Acad Sci U. S. A, 107, 8788, 10.1073/pnas.1003428107 Mullen, 2012, Reductive carboxylation supports growth in tumour cells with defective mitochondria, Nature, 481, 385, 10.1038/nature10642 Ming, 2010, UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes, Oncogene, 29, 492, 10.1038/onc.2009.357 Ming, 2010, Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C, Proc Natl Acad Sci U. S. A, 107, 22623, 10.1073/pnas.1010377108 Qiang, 2014, Regulation of cell proliferation and migration by p62 through stabilization of Twist1, Proc Natl Acad Sci U. S. A, 111, 9241, 10.1073/pnas.1322913111 Ming, 2015, Dual role of SIRT1 in UVB-induced skin tumorigenesis, Oncogene, 34, 357, 10.1038/onc.2013.583 Cheng, 2011, Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells, Cancer Biol Ther, 12, 707, 10.4161/cbt.12.8.16441 Cheng, 2012, Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death, Cancer Res, 72, 2634, 10.1158/0008-5472.CAN-11-3928 Cheng, 2015, Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: role of mitochondrial bioenergetics and energy-sensing mechanism, Cancer Lett, 365, 96, 10.1016/j.canlet.2015.05.016 Qiang, 2013, Autophagy controls p38 activation to promote cell survival under genotoxic stress, J Biol Chem, 288, 1603, 10.1074/jbc.M112.415224 Chen, 2012, Targeting protective autophagy exacerbates UV-triggered apoptotic cell death, Int J Mol Sci, 13, 1209, 10.3390/ijms13011209 Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J, 19, 5720, 10.1093/emboj/19.21.5720 Klionsky, 2008, Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes, Autophagy, 4, 151, 10.4161/auto.5338 Wu, 2013, Role of AMPK in UVB-induced DNA damage repair and growth control, Oncogene, 32, 2682, 10.1038/onc.2012.279 Qiang, 2015, Autophagy positively regulates DNA damage recognition by nucleotide excision repair, Autophagy, 0 Maiuri, 2007, Self-eating and self-killing: crosstalk between autophagy and apoptosis, Nat Rev Mol Cell Biol, 8, 741, 10.1038/nrm2239 Nunnari, 2012, Mitochondria: in sickness and in health, Cell, 148, 1145, 10.1016/j.cell.2012.02.035 Mihaylova, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism, Nat Cell Biol, 13, 1016, 10.1038/ncb2329 Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 Nixon, 2013, The role of autophagy in neurodegenerative disease, Nat Med, 19, 983, 10.1038/nm.3232 Kimmelman, 2011, The dynamic nature of autophagy in cancer, Genes Dev, 25, 1999, 10.1101/gad.17558811 Galluzzi, 2015, Autophagy in malignant transformation and cancer progression, EMBO J, 34, 856, 10.15252/embj.201490784 Zhi, 2015, Autophagy in cancer, F1000Prime Rep, 7, 18, 10.12703/P7-18 Rao, 2010, The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone, J Biol Chem, 285, 34447, 10.1074/jbc.M110.133579 Dhanasekaran, 2005, Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide, Free Radic Biol Med, 39, 567, 10.1016/j.freeradbiomed.2005.04.016