Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice

Toxicology - Tập 439 - Trang 152464 - 2020
Kenneth W. Dunn1, Michelle M. Martinez1, Zemin Wang2, Henry E. Mang1, Sherry G. Clendenon3,4, James P. Sluka3,4, James A. Glazier3,4, James E. Klaunig2
1Department of Medicine, Indiana University, Indianapolis, IN USA
2School of Public Health, Indiana University, Bloomington, IN, USA
3Biocomplexity Institute, Indiana University, Bloomington, IN, USA
4Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA

Tài liệu tham khảo

Annaert, 2005, Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes, Drug Metab. Dispos., 33, 388, 10.1124/dmd.104.001669 Anundi, 1993, Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes, Biochem. Pharmacol., 45, 1251, 10.1016/0006-2952(93)90277-4 Babbey, 2012, Quantitative intravital microscopy of hepatic transport, Intravital, 1, 10, 10.4161/intv.21296 Dai, 2006, Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse, Toxicol. Sci., 92, 33, 10.1093/toxsci/kfj192 Du, 2015, Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity, Food Chem. Toxicol., 81, 62, 10.1016/j.fct.2015.04.014 Du, 2016, Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential, Redox Biol., 10, 148, 10.1016/j.redox.2016.10.001 Du, 2016, Editor’s highlight: metformin protects against acetaminophen hepatotoxicity by attenuation of mitochondrial oxidant stress and dysfunction, Toxicol. Sci., 154, 214, 10.1093/toxsci/kfw158 Du, 2017, Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity, Arch. Toxicol., 91, 761, 10.1007/s00204-016-1692-0 Du, 2017, Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity, Food Chem. Toxicol., 108, 339, 10.1016/j.fct.2017.08.020 Dunn, 2017, Using quantitative intravital multiphoton microscopy to dissect hepatic transport in rats, Methods, 128, 40, 10.1016/j.ymeth.2017.04.015 Gamal, 2017, Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver, Sci. Rep., 7, 37541, 10.1038/srep37541 Hanawa, 2008, Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury, J. Biol. Chem., 283, 13565, 10.1074/jbc.M708916200 Hinson, 2010, Mechanisms of acetaminophen-induced liver necrosis, Handb. Exp. Pharmacol., 369, 10.1007/978-3-642-00663-0_12 Hu, 2016, Low dose acetaminophen induces reversible mitochondrial dysfunction associated with transient c-Jun N-terminal kinase activation in mouse liver, Toxicol. Sci., 150, 204, 10.1093/toxsci/kfv319 Huo, 2017, Antcin H protects against acute liver injury through disruption of the interaction of c-Jun-N-terminal kinase with mitochondria, Antioxid. Redox Signal., 26, 207, 10.1089/ars.2016.6833 Li, 2011, Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis, Cell Death Dis., 2, e183, 10.1038/cddis.2011.68 Liu, 2012, Intravital multiphoton imaging of rhodamine 123 in the rat liver after intravenous dosing, Intravital, 1, 54, 10.4161/intv.21450 McGill, 2012, The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation, J. Clin. Invest., 122, 1574, 10.1172/JCI59755 McGill, 2012, Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity, Toxicol. Appl. Pharmacol., 264, 387, 10.1016/j.taap.2012.08.015 Mitchell, 1973, Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism, J. Pharmacol. Exp. Ther., 187, 185 Mitchell, 1973, Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione, J. Pharmacol. Exp. Ther., 187, 211 Moles, 2018, Mitochondrial-lysosomal axis in acetaminophen hepatotoxicity, Front. Pharmacol., 9, 453, 10.3389/fphar.2018.00453 Naiki-Ito, 2010, Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat, Toxicol. Pathol., 38, 280, 10.1177/0192623309357951 National Research Council (U.S.). Committee for the Update of the Guide for the Care and Use of Laboratory Animals., Institute for Laboratory Animal Research (U.S.), 2011 Ni, 2013, Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver, Redox Biol., 1, 427, 10.1016/j.redox.2013.08.005 Patel, 2012, Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure, Nat. Biotechnol., 30, 179, 10.1038/nbt.2089 Pires, 2014, Interleukin-4 deficiency protects mice from acetaminophen-induced liver injury and inflammation by prevention of glutathione depletion, Inflamm. Res., 63, 61, 10.1007/s00011-013-0671-7 Ramachandran, 2017, Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology, J. Clin. Transl. Res., 3, 157 Ramachandran, 2018, Acetaminophen toxicity: novel insights into mechanisms and future perspectives, Gene Expr., 18, 19, 10.3727/105221617X15084371374138 Ramachandran, 2018, Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives, J. Clin. Transl. Res., 4, 75 Rehman, 2011, NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy, Transplantation, 91, 406, 10.1097/TP.0b013e318204bdb2 Reid, 2005, Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes, J. Pharmacol. Exp. Ther., 312, 509, 10.1124/jpet.104.075945 Roberts, 1991, Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity, Am. J. Pathol., 138, 359 Ryan, 2014, Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver, Am. J. Physiol. Regul. Integr. Comp. Physiol., 307, R1488, 10.1152/ajpregu.00371.2014 Ryan, 2018, Intravital multiphoton microscopy with fluorescent bile salts in rats as an in vivo biomarker for hepatobiliary transport inhibition, Drug Metab. Dispos., 46, 704, 10.1124/dmd.117.079277 Saito, 2014, Synchronized necrotic death of attached hepatocytes mediated via gap junctions, Sci. Rep., 4, 5169, 10.1038/srep05169 Theruvath, 2008, Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2, Transplantation, 85, 1500, 10.1097/TP.0b013e31816fefb5 Wang, 2015, Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging, Biomed. Opt. Express, 6, 780, 10.1364/BOE.6.000780 Win, 2011, c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice, J. Biol. Chem., 286, 35071, 10.1074/jbc.M111.276089 Xie, 2015, Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury, Toxicol. Appl. Pharmacol., 286, 1, 10.1016/j.taap.2015.03.019 Yan, 2010, The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes, Toxicol. Sci., 117, 515, 10.1093/toxsci/kfq208 Yuan, 2013, Mechanisms of drug-induced liver injury, Clin. Liver Dis., 17, 507, 10.1016/j.cld.2013.07.002