Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Bai, 1999, Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury, J. Biol. Chem., 274, 26217, 10.1074/jbc.274.37.26217

Berra, 2003, HIF prolylhydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia, EMBO J., 22, 4082, 10.1093/emboj/cdg392

Brunelle, 2005, Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation, Cell Metab., 1, 409, 10.1016/j.cmet.2005.05.002

Bunn, 1996, Oxygen sensing and molecular adaptation to hypoxia, Physiol. Rev., 76, 839, 10.1152/physrev.1996.76.3.839

Chandel, 1998, Mitochondrial reactive oxygen species trigger hypoxia-induced transcription, Proc. Natl. Acad. Sci. USA, 95, 11715, 10.1073/pnas.95.20.11715

Chandel, 2000, Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1a during hypoxia: a mechanism of O2 sensing, J. Biol. Chem., 275, 25130, 10.1074/jbc.M001914200

Epstein, 2001, C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, 107, 43, 10.1016/S0092-8674(01)00507-4

Fox, 2003, The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor, Genes Dev., 17, 1841, 10.1101/gad.1105003

Gorlach, 2003, Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1, Thromb. Haemost., 89, 926, 10.1055/s-0037-1613480

Hagen, 2003, Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha, Science, 302, 1975, 10.1126/science.1088805

Hirsilae, 2003, Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor, J. Biol. Chem., 278, 30772, 10.1074/jbc.M304982200

Huang, 1998, Regulation of hypoxia-inducible factor 1alpha is mediated by an O2- dependent degradation domain via the ubiquitin-proteasome pathway, Proc. Natl. Acad. Sci. USA, 95, 7987, 10.1073/pnas.95.14.7987

Ivan, 2001, HIF-alpha target for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing, Science, 292, 464, 10.1126/science.1059817

Jaakkola, 2001, Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2 regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796

Jakob, 1999, Chaperone activity with a redox switch, Cell, 96, 341, 10.1016/S0092-8674(00)80547-4

Kallio, 1997, Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor, Proc. Natl. Acad. Sci. USA, 94, 5667, 10.1073/pnas.94.11.5667

King, 1989, Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation, Science, 246, 500, 10.1126/science.2814477

Link, 1996, Functional implications of the structure of the ‘Rieske’ iron-sulfur protein of bovine heart mitochondrial cytochrome bc1 complex, Biochim. Biophys. Acta, 1275, 54, 10.1016/0005-2728(96)00050-3

Mansfield, 2005, Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation, Cell Metab., 1, 393, 10.1016/j.cmet.2005.05.003

Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459

Muller, 2004, Complex III releases superoxide to both sides of the inner mitochondrial membrane, J. Biol. Chem., 279, 49064, 10.1074/jbc.M407715200

Paddison, 2002, Stable suppression of gene expression by RNAi in mammalian cells, Proc. Natl. Acad. Sci. USA, 99, 1443, 10.1073/pnas.032652399

Schewe, 1995, Molecular actions of ebselen—an antiinflammatory antioxidant, Gen. Pharmacol., 26, 1153, 10.1016/0306-3623(95)00003-J

Schroedl, 2002, Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species, Am. J. Physiol. Lung Cell. Mol. Physiol., 283, L922, 10.1152/ajplung.00014.2002

Srinivas, 2001, Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway, J. Biol. Chem., 276, 21995, 10.1074/jbc.C100177200

Vaux, 2001, Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain, Blood, 98, 296, 10.1182/blood.V98.2.296

Wang, 1995, Purification and characterization of hypoxia-inducible factor 1, J. Biol. Chem., 270, 1230, 10.1074/jbc.270.3.1230

Zwacka, 1998, Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis, Hum. Gene Ther., 9, 1381, 10.1089/hum.1998.9.9-1381

Zwacka, 1998, Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation, Nat. Med., 4, 698, 10.1038/nm0698-698