Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Immunity - Tập 36 Số 1 - Trang 68-78 - 2012
Gerritje J. W. van der Windt1, Bart Everts1, Chih‐Hao Chang1, Jonathan D. Curtis1, Tori C. Freitas1, Eyal Amiel1, Edward J. Pearce1, Erika L. Pearce1
1Trudeau Institute, Saranac Lake, NY 12983, USA

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Beeson, 2010, A high-throughput respirometric assay for mitochondrial biogenesis and toxicity, Anal. Biochem., 404, 75, 10.1016/j.ab.2010.04.040

Brand, 1997, Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species, FASEB J., 11, 388, 10.1096/fasebj.11.5.9141507

Carrio, 2004, Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment, J. Immunol., 172, 7315, 10.4049/jimmunol.172.12.7315

Chang, 2007, Asymmetric T lymphocyte division in the initiation of adaptive immune responses, Science, 315, 1687, 10.1126/science.1139393

Choi, 2009, Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure, J. Neurochem., 109, 1179, 10.1111/j.1471-4159.2009.06055.x

Cornish, 2006, Differential regulation of T cell growth by IL-2 and IL-15, Blood, 108, 600, 10.1182/blood-2005-12-4827

D'Souza, 2007, Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation, Mitochondrion, 7, 374, 10.1016/j.mito.2007.08.001

Deberardinis, 2006, Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth, J. Biol. Chem., 281, 37372, 10.1074/jbc.M608372200

Ferrick, 2008, Advances in measuring cellular bioenergetics using extracellular flux, Drug Discov. Today, 13, 268, 10.1016/j.drudis.2007.12.008

Fox, 2005, Fuel feeds function: energy metabolism and the T-cell response, Nat. Rev. Immunol., 5, 844, 10.1038/nri1710

Frauwirth, 2002, The CD28 signaling pathway regulates glucose metabolism, Immunity, 16, 769, 10.1016/S1074-7613(02)00323-0

Gerencser, 2009, Quantitative microplate-based respirometry with correction for oxygen diffusion, Anal. Chem., 81, 6868, 10.1021/ac900881z

Grayson, 2000, Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells, J. Immunol., 164, 3950, 10.4049/jimmunol.164.8.3950

Grayson, 2003, Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection, J. Immunol., 170, 4745, 10.4049/jimmunol.170.9.4745

Greiner, 1994, Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production, J. Biol. Chem., 269, 31484, 10.1016/S0021-9258(18)31720-4

Guo, 2009, DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination, Mitochondrion, 9, 261, 10.1016/j.mito.2009.03.003

Harty, 2008, Shaping and reshaping CD8+ T-cell memory, Nat. Rev. Immunol., 8, 107, 10.1038/nri2251

Hofmann, 2002, Cytokines and their role in lymphoid development, differentiation and homeostasis, Curr. Opin. Allergy Clin. Immunol., 2, 495, 10.1097/00130832-200212000-00004

Jones, 2007, Revving the engine: signal transduction fuels T cell activation, Immunity, 27, 173, 10.1016/j.immuni.2007.07.008

Kaech, 2003, Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells, Nat. Immunol., 4, 1191, 10.1038/ni1009

Kennedy, 2000, Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice, J. Exp. Med., 191, 771, 10.1084/jem.191.5.771

Krauss, 2001, Signaling takes a breath—new quantitative perspectives on bioenergetics and signal transduction, Immunity, 15, 497, 10.1016/S1074-7613(01)00205-9

Ku, 2000, Control of homeostasis of CD8+ memory T cells by opposing cytokines, Science, 288, 675, 10.1126/science.288.5466.675

Lambert, 2009, Reactive oxygen species production by mitochondria, Methods Mol. Biol., 554, 165, 10.1007/978-1-59745-521-3_11

Lopaschuk, 1988, Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine, Circ. Res., 63, 1036, 10.1161/01.RES.63.6.1036

McGill, 2010, IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection, J. Exp. Med., 207, 521, 10.1084/jem.20091711

Mitchell, 2010, Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells, J. Immunol., 184, 6719, 10.4049/jimmunol.0904089

Mookerjee, 2010, Mitochondrial uncoupling and lifespan, Mech. Ageing Dev., 131, 463, 10.1016/j.mad.2010.03.010

Nicholls, 2009, Spare respiratory capacity, oxidative stress and excitotoxicity, Biochem. Soc. Trans., 37, 1385, 10.1042/BST0371385

Nicholls, 2010, Bioenergetic profile experiment using C2C12 myoblast cells, J. Vis. Exp., 10.3791/2511

Pearce, 2009, Enhancing CD8 T-cell memory by modulating fatty acid metabolism, Nature, 460, 103, 10.1038/nature08097

Prlic, 2007, Requirements for CD8 T-cell priming, memory generation and maintenance, Curr. Opin. Immunol., 19, 315, 10.1016/j.coi.2007.04.010

Ramsay, 2004, Carnitine acyltransferases and their influence on CoA pools in health and disease, Mol. Aspects Med., 25, 475, 10.1016/j.mam.2004.06.002

Rathmell, 2000, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability, Mol. Cell, 6, 683, 10.1016/S1097-2765(00)00066-6

Roos, 1973, Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation, Exp. Cell Res., 77, 127, 10.1016/0014-4827(73)90561-2

Sandau, 2010, IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool, J. Immunol., 184, 35, 10.4049/jimmunol.0803355

Saraste, 1999, Oxidative phosphorylation at the fin de siècle, Science, 283, 1488, 10.1126/science.283.5407.1488

Schluns, 2002, Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells, J. Immunol., 168, 4827, 10.4049/jimmunol.168.10.4827

Stonier, 2008, Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation, Blood, 112, 4546, 10.1182/blood-2008-05-156307

Surh, 2008, Homeostasis of naive and memory T cells, Immunity, 29, 848, 10.1016/j.immuni.2008.11.002

Tan, 2002, Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells, J. Exp. Med., 195, 1523, 10.1084/jem.20020066

Waldmann, 1998, Interleukin-2, interleukin-15, and their receptors, Int. Rev. Immunol., 16, 205, 10.3109/08830189809042995

Wang, 1976, Aerobic glycolysis during lymphocyte proliferation, Nature, 261, 702, 10.1038/261702a0

Warburg, 1956, On respiratory impairment in cancer cells, Science, 124, 269, 10.1126/science.124.3215.269

Wieman, 2007, Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking, Mol. Biol. Cell, 18, 1437, 10.1091/mbc.e06-07-0593

Yadava, 2007, Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone, J. Neurosci., 27, 7310, 10.1523/JNEUROSCI.0212-07.2007

Yi, 2006, Electron transport complex I is required for CD8+ T cell function, J. Immunol., 177, 852, 10.4049/jimmunol.177.2.852

Zaugg, 2011, Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress, Genes Dev., 25, 1041, 10.1101/gad.1987211

Zhang, 1998, Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15, Immunity, 8, 591, 10.1016/S1074-7613(00)80564-6