Mitochondrial Replacement: Ethics and Identity

Bioethics - Tập 29 Số 9 - Trang 631-638 - 2015
Anthony Wrigley1, Stephen Wilkinson2, John Appleby3
1Address for correspondence: Dr. Anthony Wrigley, Centre for Professional Ethics (PEAK), Chancellor's Building, University of Keele, Keele, ST5 5BG. Tel: +44 (0)1782 734084 Email: [email protected]
2LANCASTER UNIVERSITY,
3Laws

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AbstractMitochondrial replacement techniques (MRTs) have the potential to allow prospective parents who are at risk of passing on debilitating or even life‐threatening mitochondrial disorders to have healthy children to whom they are genetically related. Ethical concerns have however been raised about these techniques. This article focuses on one aspect of the ethical debate, the question of whether there is any moral difference between the two types of MRT proposed: Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST). It examines how questions of identity impact on the ethical evaluation of each technique and argues that there is an important difference between the two. PNT, it is argued, is a form of therapy based on embryo modification while MST is, instead, an instance of selective reproduction. The article's main ethical conclusion is that, in some circumstances, there is a stronger obligation to use PNT than MST.

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