Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1

Neurobiology of Disease - Tập 23 - Trang 11-22 - 2006
Gina M. Leinninger1, Carey Backus2, Ann Marie Sastry3, Yun-Bo Yi3, Chia-Wei Wang3, Eva L. Feldman2
1Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
2Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
3Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA

Tài liệu tham khảo

Alexander, 2000, OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nat. Genet., 26, 211, 10.1038/79944 Arai, 2004, Establishment of stable hFis1 knockdown cells with an siRNA expression vector, J. Biochem. (Tokyo), 136, 421, 10.1093/jb/mvh139 Bach, 2003, Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity, J. Biol. Chem., 278, 17190, 10.1074/jbc.M212754200 Bach, 2005, Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor {alpha} and interleukin-6, Diabetes, 54, 2685, 10.2337/diabetes.54.9.2685 Beal, 2005, Mitochondria take center stage in aging and neurodegeneration, Ann. Neurol., 58, 495, 10.1002/ana.20624 Bouillet, 2002, BH3-only proteins—Evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death, J. Cell Sci., 115, 1567, 10.1242/jcs.115.8.1567 Cartron, 2004, The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA, Mol. Cell, 16, 807, 10.1016/j.molcel.2004.10.028 Cartron, 2005, Distinct domains control the addressing and the insertion of Bax into mitochondria, J. Biol. Chem., 280, 10587, 10.1074/jbc.M409714200 Chen, 2004, Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling, Proc. Natl. Acad. Sci. U. S. A., 101, 1235, 10.1073/pnas.0308050100 Chrysis, 2001, Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner, J. Neurosci., 21, 1481, 10.1523/JNEUROSCI.21-05-01481.2001 Courteix, 1993, Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain, Pain, 53, 81, 10.1016/0304-3959(93)90059-X Delettre, 2000, Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nat. Genet., 26, 207, 10.1038/79936 Frank, 2001, The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, 1, 515, 10.1016/S1534-5807(01)00055-7 Jagasia, 2005, DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans, Nature, 433, 754, 10.1038/nature03316 Kalichman, 1998, Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy, Acta Neuropathol. (Berl.), 95, 47, 10.1007/s004010050764 Kang, 2005, Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer, Curr. Med. Chem., 12, 429, 10.2174/0929867053363081 Karbowski, 2003, Dynamics of mitochondrial morphology in healthy cells and during apoptosis, Cell Death Differ., 10, 870, 10.1038/sj.cdd.4401260 Karbowski, 2002, Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis, J. Cell Biol., 159, 931, 10.1083/jcb.200209124 Karbowski, 2004, Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis, J. Cell Biol., 164, 493, 10.1083/jcb.200309082 Kuwana, 2003, Bcl-2-family proteins and the role of mitochondria in apoptosis, Curr. Opin. Cell Biol., 15, 691, 10.1016/j.ceb.2003.10.004 Kuwana, 2002, Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X Kuwana, 2005, BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly, Mol. Cell, 17, 525, 10.1016/j.molcel.2005.02.003 Le, 2005, Reactive oxygen species and the mitochondrial signaling pathway of cell death, Histol. Histopathol., 20, 205 Lee, 2004, Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis, Mol. Biol. Cell, 15, 5001, 10.1091/mbc.E04-04-0294 Leinninger, 2005, Insulin-like growth factors in the treatment of neurological disease, 35 Leinninger, 2004, Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons, FASEB J., 18, 1544, 10.1096/fj.04-1581fje Leinninger, 2004, Insulin-like growth factor-I (IGF-I) regulates glucose-induced mitochondrial depolarization and apoptosis in human neuroblastoma, Cell Death Differ., 11, 885, 10.1038/sj.cdd.4401429 Leinninger, 2004, The role of growth factors in diabetic peripheral neuropathy, J. Peripher. Nerv. Syst., 9, 26, 10.1111/j.1085-9489.2004.09105.x Li, 2004, The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses, Cell, 119, 873, 10.1016/j.cell.2004.11.003 Linseman, 2002, Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons, J. Neurosci., 22, 9287, 10.1523/JNEUROSCI.22-21-09287.2002 Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9 Makin, 2001, Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate, EMBO J., 20, 6306, 10.1093/emboj/20.22.6306 Mayfield, 1998, Diagnosis and classification of diabetes mellitus: new criteria, Am. Fam. Physician, 58, 1355 Miller, 2004, Axonal mitochondrial transport and potential are correlated, J. Cell Sci., 117, 2791, 10.1242/jcs.01130 Ness, 2004, IGF-I prevents glutamate-mediated bax translocation and cytochrome c release in O4+ oligodendrocyte progenitors, Glia, 46, 183, 10.1002/glia.10360 Okuno, 2004, The c-Jun N-terminal protein kinase signaling pathway mediates bax activation and subsequent neuronal apoptosis through interaction with bim after transient focal cerebral ischemia, J. Neurosci., 24, 7879, 10.1523/JNEUROSCI.1745-04.2004 Putcha, 2001, Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis, Neuron, 29, 615, 10.1016/S0896-6273(01)00238-0 Puthalakath, 2002, Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins, Cell Death Differ., 9, 505, 10.1038/sj.cdd.4400998 Puthalakath, 1999, The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex, Mol. Cell, 3, 287, 10.1016/S1097-2765(00)80456-6 Rube, 2004, Mitochondrial morphology is dynamic and varied, Mol. Cell. Biochem., 256–257, 331, 10.1023/B:MCBI.0000009879.01256.f6 Russell, 1999, Neurons undergo apoptosis in animal and cell culture models of diabetes, Neurobiol. Dis., 6, 347, 10.1006/nbdi.1999.0254 Russell, 2002, High glucose induced oxidative stress and mitochondrial dysfunction in neurons, FASEB J., 16, 1738, 10.1096/fj.01-1027com Sawada, 2003, Ku70 suppresses the apoptotic translocation of Bax to mitochondria, Nat. Cell Biol., 5, 320, 10.1038/ncb950 Schinzel, 2004, Conformational control of Bax localization and apoptotic activity by Pro168, J. Cell Biol., 164, 1021, 10.1083/jcb.200309013 Schmeichel, 2003, Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy, Diabetes, 52, 165, 10.2337/diabetes.52.1.165 Shibata, 2002, Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice, J. Cereb. Blood Flow Metab., 22, 810, 10.1097/00004647-200207000-00006 Sperandio, 2000, An alternative, nonapoptotic form of programmed cell death, Proc. Natl. Acad. Sci. U. S. A., 97, 14376, 10.1073/pnas.97.26.14376 Szabadkai, 2004, Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis, Mol. Cell, 16, 59, 10.1016/j.molcel.2004.09.026 1993, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus, N. Engl. J. Med., 329, 977, 10.1056/NEJM199309303291401 Vincent, 2004, New insights into the mechanisms of diabetic neuropathy, Rev. Endocr. Metab. Dis., 5, 227, 10.1023/B:REMD.0000032411.11422.e0 Vincent, 2004, IGF-I prevents glutamate-induced motor neuron programmed cell death, Neurobiol. Dis., 16, 407, 10.1016/j.nbd.2004.03.001 Vincent, 2004, Oxidative stress in the pathogenesis of diabetic neuropathy, Endocr. Rev., 25, 612, 10.1210/er.2003-0019 Vincent, 2005, Short-term hyperglycemia produces oxidative damage and apoptosis in neurons, FASEB J., 19, 638, 10.1096/fj.04-2513fje Xu, 2004, Mitochondrial degeneration in amyotrophic lateral sclerosis, J. Bioenerg. Biomembr., 36, 395, 10.1023/B:JOBB.0000041774.12654.e1 Yu, 2003, GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway, J. Cell Biol., 163, 987, 10.1083/jcb.200305083 Zeevalk, 2005, Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration, Antioxid. Redox Signal., 7, 1117, 10.1089/ars.2005.7.1117 Zuchner, 2004, Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot–Marie–Tooth neuropathy type 2A, Nat. Genet., 36, 449, 10.1038/ng1341