Mitochondria, endothelial cell function, and vascular diseases

Abu-Amero, 2006, Prothrombotic and atherosclerotic risk factors lack significance in NAION patients harbouring mitochondrial DNA mutations, Br. J. Ophthalmol, 90, 119, 10.1136/bjo.2005.078071

Al-Mehdi, 2012, Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription, Sci. Signal, 5, ra47, 10.1126/scisignal.2002712

Andersen, 2005, PGC-1α Gly482Ser polymorphism associates with hypertension among danish whites, Hypertension, 45, 565, 10.1161/01.HYP.0000158946.53289.24

Andrukhova, 2013, Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice, Mol. Endocrinol, 28, 53, 10.1210/me.2013-1252

Archer, 2010, Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target, Circulation, 121, 2661, 10.1161/CIRCULATIONAHA.109.916098

Ballinger, 2002, Mitochondrial integrity and function in atherogenesis, Circulation, 106, 544, 10.1161/01.CIR.0000023921.93743.89

Ballinger, 2000, Hydrogen peroxide– and peroxynitrite-induced mitochondrial dna damage and dysfunction in vascular endothelial and smooth muscle cells, Circ. Res, 86, 960, 10.1161/01.RES.86.9.960

Beresewicz, 2004, Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart, Cardiovasc. Res, 63, 118, 10.1016/j.cardiores.2004.02.012

Bhatt, 2013, C-Peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes, Diabetes, 62, 3851, 10.2337/db13-0039

Brownlee, 2001, Biochemistry and molecular cell biology of diabetic complications, Nature, 414, 813, 10.1038/414813a

Cai, 2008, CaM Kinase II-dependent pathophysiological signalling in endothelial cells, Cardiovasc. Res, 77, 30, 10.1093/cvr/cvm010

Ceolotto, 2007, Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism, Arterioscler. Thromb. Vasc. Biol, 27, 2627, 10.1161/ATVBAHA.107.155762

Chacko, 2010, Prevention of diabetic nephropathy in Ins2(+/)(-)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ, Biochem. J, 432, 9, 10.1042/BJ20100308

Chen, 2013, Cross-talk between SIRT1 and p66Shc in vascular diseases, Trends Cardiovasc. Med, 23, 237, 10.1016/j.tcm.2013.01.001

Cheurfa, 2004, The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-γ coactivator-1 gene is associated with hypertension in type 2 diabetic men, Diabetologia, 47, 1980, 10.1007/s00125-004-1567-4

Civitarese, 2007, Calorie restriction increases muscle mitochondrial biogenesis in healthy humans, PLoS Med, 4, e76, 10.1371/journal.pmed.0040076

Colman, 2009, Caloric restriction delays disease onset and mortality in rhesus monkeys, Science, 325, 201, 10.1126/science.1173635

Csiszar, 2009, Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats, Hypertension, 54, 668, 10.1161/HYPERTENSIONAHA.109.133397

Csordás, 2013, MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter, Cell Metab, 17, 976, 10.1016/j.cmet.2013.04.020

Cui, 2006, Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy, Exp. Eye Res, 83, 807, 10.1016/j.exer.2006.03.024

Culic, 1997, Energy turnover of vascular endothelial cells, Am. J. Physiol, 273, C205, 10.1152/ajpcell.1997.273.1.C205

Daehn, 2014, Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis, J. Clin. Invest, 124, 1608, 10.1172/JCI71195

Dai, 2012, Mitochondria and cardiovascular aging, Circ. Res, 110, 1109, 10.1161/CIRCRESAHA.111.246140

Davidson, 2007, Endothelial mitochondria: contributing to vascular function and disease, Circ. Res, 100, 1128, 10.1161/01.RES.0000261970.18328.1d

Dedkova, 2004, Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells, Am. J. Physiol Cell Physiol, 286, C406, 10.1152/ajpcell.00155.2003

Detaille, 2005, Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process, Diabetes, 54, 2179, 10.2337/diabetes.54.7.2179

Detmer, 2007, Functions and dysfunctions of mitochondrial dynamics, Nat. Rev. Mol. Cell Biol, 8, 870, 10.1038/nrm2275

Devarajan, 2011, Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis, Antioxid. Redox Signal, 14, 341, 10.1089/ars.2010.3430

Dhanasekaran, 2004, Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis, J. Biol. Chem, 279, 37575, 10.1074/jbc.M404003200

Dikalov, 2008, Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production, Free Radic. Biol. Med, 45, 1340, 10.1016/j.freeradbiomed.2008.08.013

Dikalov, 2014, Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension, Antioxid. Redox Signal, 20, 281, 10.1089/ars.2012.4918

Dikalova, 2010, Therapeutic targeting of mitochondrial superoxide in hypertension, Circ. Res, 107, 106, 10.1161/CIRCRESAHA.109.214601

Dong, 2013, Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis, Cell Metab, 18, 118, 10.1016/j.cmet.2013.06.003

Dromparis, 2013, Mitochondria in vascular health and disease, Annu. Rev. Physiol, 75, 95, 10.1146/annurev-physiol-030212-183804

Du, 2006, Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation, J. Clin. Invest, 116, 1071, 10.1172/JCI23354

Du, 2003, Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells, J. Clin. Invest, 112, 1049, 10.1172/JCI200318127

Duriez, 2000, A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor, J. Biol. Chem, 275, 18099, 10.1074/jbc.M908925199

Duval, 2002, Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells, Biochem. Cell Biol, 80, 757, 10.1139/o02-158

Feng, 2011, Isoflurane preconditioning increases endothelial cell tolerance to in-vitro simulated ischaemia, J. Pharm. Pharmacol, 63, 106, 10.1111/j.2042-7158.2010.01198.x

Fijalkowska, 2010, Hypoxia inducible-factor1α regulates the metabolic shift of pulmonary hypertensive endothelial cells, Am. J. Pathol, 176, 1130, 10.2353/ajpath.2010.090832

Finckenberg, 2012, Caloric restriction ameliorates angiotensin II–induced mitochondrial remodeling and cardiac hypertrophy, Hypertension, 59, 76, 10.1161/HYPERTENSIONAHA.111.179457

Fontana, 2004, Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans, Proc. Natl. Acad. Sci. U.S.A, 101, 6659, 10.1073/pnas.0308291101

Fontana, 2010, Extending healthy life span–from yeast to humans, Science, 328, 321, 10.1126/science.1172539

Francia, 2004, Deletion of p66shc gene protects against age-related endothelial dysfunction, Circulation, 110, 2889, 10.1161/01.CIR.0000147731.24444.4D

Fujisawa, 2009, TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis, Biochem. Biophys. Res. Commun, 379, 43, 10.1016/j.bbrc.2008.11.141

Giorgio, 2005, Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis, Cell, 122, 221, 10.1016/j.cell.2005.05.011

Graham, 2009, Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy, Hypertension, 54, 322, 10.1161/HYPERTENSIONAHA.109.130351

Gredilla, 2001, Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart, FASEB J, 15, 1589, 10.1096/fj.00-0764fje

Guo, 2002, Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice, Mech. Ageing Dev, 123, 1121, 10.1016/S0047-6374(02)00008-8

Hernandez-Mijares, 2013, Human leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2 diabetic patients and their association with silent myocardial ischemia, Diabetes Care, 36, 1695, 10.2337/dc12-1224

Higdon, 2012, Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy, Am. J. Physiol. Heart Circ. Physiol, 302, H1394, 10.1152/ajpheart.00584.2011

Hou, 2010, FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling, Mol. Cell. Endocrinol, 321, 194, 10.1016/j.mce.2010.02.037

Huang, 2012, Diazoxide inhibits aortic endothelial cell apoptosis in diabetic rats via activation of ERK, Acta Diabetol, 49, 205, 10.1007/s00592-011-0288-7

James, 2005, Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools, J. Biol. Chem, 280, 21295, 10.1074/jbc.M501527200

Jendrach, 2005, Morpho-dynamic changes of mitochondria during ageing of human endothelial cells, Mech. Ageing Dev, 126, 813, 10.1016/j.mad.2005.03.002

Jian, 2013, Metformin stimulated AMPKα1 promotes microvascular repair in acute lung injury, Am. J. Physiol. Lung Cell. Mol. Physiol, 305, L844, 10.1152/ajplung.00173.2013

Jin, 2011, Age-dependent association of the polymorphisms in the mitochondria-shaping gene, OPA1, with blood pressure and hypertension in Korean population, Am. J. Hypertens, 24, 1127, 10.1038/ajh.2011.131

Jornot, 1999, Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger, J. Cell Sci, 112(pt 7), 1013, 10.1242/jcs.112.7.1013

Katakam, 2013, Depolarization of mitochondria in endothelial cells promotes cerebral artery vasodilation by activation of nitric oxide synthase, Arterioscler. Thromb. Vasc. Biol, 33, 752, 10.1161/ATVBAHA.112.300560

Kizhakekuttu, 2012, Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus–related endothelial dysfunction in humans, Arterioscler. Thromb. Vasc. Biol, 32, 2531, 10.1161/ATVBAHA.112.256024

Kluge, 2013, Mitochondria and endothelial function, Circ. Res, 112, 1171, 10.1161/CIRCRESAHA.111.300233

Koziel, 2013, Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4, Biochem. J, 452, 231, 10.1042/BJ20121778

Kroemer, 2007, Mitochondrial membrane permeabilization in cell death, Physiol. Rev, 87, 99, 10.1152/physrev.00013.2006

Kröller-Schön, 2013, Proliferator coactivator 1α deletion induces angiotensin II–associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation, Arterioscler. Thromb. Vasc. Biol, 33, 1928, 10.1161/ATVBAHA.113.301717

Kukidome, 2006, Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells, Diabetes, 55, 120, 10.2337/diabetes.55.01.06.db05-0943

Lassègue, 2012, Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular, Circ. Res, 110, 1364, 10.1161/CIRCRESAHA.111.243972

Lee, 2005, Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis, Circ. Res, 96, 1200, 10.1161/01.RES.0000170075.73039.5b

Lefevre, 2009, Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals, Atherosclerosis, 203, 206, 10.1016/j.atherosclerosis.2008.05.036

Li, 2012, Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus–induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice, Circulation, 126, 1267, 10.1161/CIRCULATIONAHA.112.108159

Li, 2013, Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease, Curr. Opin. Pharmacol, 13, 161, 10.1016/j.coph.2013.01.006

Li, 2009, Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells, Biochem. Biophys. Res. Commun, 381, 660, 10.1016/j.bbrc.2009.02.132

Libby, 2011, Progress and challenges in translating the biology of atherosclerosis, Nature, 473, 317, 10.1038/nature10146

Liu, 2008, Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles, Med. Biol. Eng. Comput, 46, 469, 10.1007/s11517-008-0331-1

López-Lluch, 2006, Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency, Proc. Natl. Acad. Sci. U.S.A, 103, 1768, 10.1073/pnas.0510452103

Mackenzie, 2013, Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes, Clin. Sci, 124, 403, 10.1042/CS20120239

Mai, 2010, Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1, J. Cell Sci, 123, 917, 10.1242/jcs.059246

Mai, 2012, Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan, Autophagy, 8, 47, 10.4161/auto.8.1.18174

Mallilankaraman, 2012, MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism, Nat. Cell Biol, 14, 1336, 10.1038/ncb2622

Martin-Padura, 2008, p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice, Endothelium, 15, 276, 10.1080/10623320802487791

Matsunaga, 2001, Glycated high-density lipoprotein induces apoptosis of endothelial cells via a mitochondrial dysfunction, Biochem. Biophys. Res. Commun, 287, 714, 10.1006/bbrc.2001.5625

Mercer, 2012, The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice, Free Radic. Biol. Med, 52, 841, 10.1016/j.freeradbiomed.2011.11.026

Mertens, 1990, Energetic response of coronary endothelial cells to hypoxia, Am. J. Physiol, 258, H689

Miller, 2010, MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure, Am. J. Physiol. Heart Circ. Physiol, 298, H1600, 10.1152/ajpheart.01108.2009

Minamino, 2007, Vascular cell senescence: contribution to atherosclerosis, Circ. Res, 100, 15, 10.1161/01.RES.0000256837.40544.4a

Minamino, 2002, Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction, Circulation, 105, 1541, 10.1161/01.CIR.0000013836.85741.17

Minocherhomji, 2012, Mitochondrial regulation of epigenetics and its role in human diseases, Epigenetics, 7, 326, 10.4161/epi.19547

Mironov, 2005, [Ca2+]i signaling between mitochondria and endoplasmic reticulum in neurons is regulated by microtubules. From mitochondrial permeability transition pore to Ca2+-induced Ca2+ release, J. Biol. Chem, 280, 715, 10.1074/jbc.M409819200

Mitra, 2009, A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase, Proc. Natl. Acad. Sci. U.S.A, 106, 11960, 10.1073/pnas.0904875106

Morales, 2001, Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation, Nephrol. Dial. Transplant, 16, 121, 10.1093/ndt/16.suppl_1.121

Nakagami, 2002, Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane, Diabetes, 51, 2604, 10.2337/diabetes.51.8.2604

Napoli, 2003, Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet, Proc. Natl. Acad. Sci. U.S.A, 100, 2112, 10.1073/pnas.0336359100

Nazarewicz, 2013, Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress, Am. J. Physiol. Heart Circ. Physiol, 305, H1131, 10.1152/ajpheart.00063.2013

Nishikawa, 2000, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature, 404, 787, 10.1038/35008121

Nishimura, 2001, 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats, Am. J. Respir. Crit. Care Med, 163, 498, 10.1164/ajrccm.163.2.2006093

Nisoli, 2005, Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS, Science, 310, 314, 10.1126/science.1117728

Nomiyama, 2004, Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients, Ann. N.Y. Acad. Sci, 1011, 193, 10.1196/annals.1293.020

Norman, 2014, Vitamin D and cardiovascular disease, Circ. Res, 114, 379, 10.1161/CIRCRESAHA.113.301241

Oberkofler, 2003, Peroxisome proliferator–activated receptor-γ coactivator-1 gene locus: associations with hypertension in middle-aged men, Hypertension, 41, 368, 10.1161/01.HYP.0000050962.48249.B7

Ong, 2010, Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury, Circulation, 121, 2012, 10.1161/CIRCULATIONAHA.109.906610

Paneni, 2012, Gene silencing of the mitochondrial adaptor p66Shc suppresses vascular hyperglycemic memory in diabetes, Circ. Res, 111, 278, 10.1161/CIRCRESAHA.112.266593

Parra-Bonilla, 2010, Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation, Am. J. Physiol. Lung Cell. Mol. Physiol, 299, L513, 10.1152/ajplung.00274.2009

Passos, 2007, Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence, PLoS Biol, 5, e110, 10.1371/journal.pbio.0050110

Perrone, 2009, Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions, J. Cell. Physiol, 221, 262, 10.1002/jcp.21852

Puddu, 2008, The molecular sources of reactive oxygen species in hypertension, Blood Press, 17, 70, 10.1080/08037050802029954

Quintero, 2006, Mitochondria as signaling organelles in the vascular endothelium, Proc. Natl. Acad. Sci. U.S.A, 103, 5379, 10.1073/pnas.0601026103

Recchioni, 2002, Apoptosis in human aortic endothelial cells induced by hyperglycemic condition involves mitochondrial depolarization and is prevented by N-acetyl-L-cysteine, Metabolism, 51, 1384, 10.1053/meta.2002.35579

Rizzuto, 2012, Mitochondria as sensors and regulators of calcium signalling, Nat. Rev. Mol. Cell Biol, 13, 566, 10.1038/nrm3412

Rowlands, 2011, Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels, J. Clin. Invest, 121, 1986, 10.1172/JCI43839

Schröder, 2012, Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase, Circ. Res, 110, 1217, 10.1161/CIRCRESAHA.112.267054

Schulz, 2008, Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction, Circulation, 118, 1347, 10.1161/CIRCULATIONAHA.108.784289

Schulze, 2004, Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein, J. Biol. Chem, 279, 30369, 10.1074/jbc.M400549200

Sena, 2012, Physiological roles of mitochondrial reactive oxygen species, Mol. Cell, 48, 158, 10.1016/j.molcel.2012.09.025

She, 2012, The human paraoxonase gene cluster as a target in the treatment of atherosclerosis, Antioxid. Redox Signal, 16, 597, 10.1089/ars.2010.3774

Shenouda, 2011, Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus, Circulation, 124, 444, 10.1161/CIRCULATIONAHA.110.014506

Shimasaki, 2013, Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics, Circ. Res, 113, 891, 10.1161/CIRCRESAHA.113.301319

Smiraglia, 2008, A novel role for mitochondria in regulating epigenetic modifications in the nucleus, Cancer Biol. Ther, 7, 1182, 10.4161/cbt.7.8.6215

Smith, 2012, Mitochondrial pharmacology, Trends Pharmacol. Sci, 33, 341, 10.1016/j.tips.2012.03.010

Smith, 2010, Animal and human studies with the mitochondria-targeted antioxidant MitoQ, Ann. N.Y. Acad. Sci, 1201, 96, 10.1111/j.1749-6632.2010.05627.x

Sobenin, 2012a, Mutation C3256T of mitochondrial genome in white blood cells: novel genetic marker of atherosclerosis and coronary heart disease, PLoS ONE, 7, e46573, 10.1371/journal.pone.0046573

Sobenin, 2012b, Mitochondrial mutations are associated with atherosclerotic lesions in the human aorta, Clin. Dev. Immunol, 2012, 5, 10.1155/2012/832464

Sobenin, 2013, Association of mitochondrial genetic variation with carotid atherosclerosis, PLoS ONE, 8, e68070, 10.1371/journal.pone.0068070

Spahr, 1989, Fatty acids are not an important fuel for coronary microvascular endothelial cells, Mol. Cell. Biochem, 88, 59, 10.1007/BF00223424

Sud, 2008, Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction, Am. J. Physiol. Cell Physiol, 294, C1407, 10.1152/ajpcell.00384.2007

Sugden, 2008, Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels, Diabet. Med, 25, 320, 10.1111/j.1464-5491.2007.02360.x

Sun, 2013a, TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction, Cardiovasc. Diabetol, 12, 1, 10.1186/1475-2840-12-69

Sun, 2011, C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow, Am. J. Respir. Cell Mol. Biol, 45, 163, 10.1165/rcmb.2009-0467OC

Sun, 2013b, Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow, Antioxid. Redox Signal, 18, 1739, 10.1089/ars.2012.4806

Sun, 2013c, Glomerular endothelial cell injury and damage precedes that of podocytes in adriamycin-induced nephropathy, PLoS ONE, 8, e55027, 10.1371/journal.pone.0055027

Sutendra, 2011, The role of Nogo and the mitochondria–endoplasmic reticulum unit in pulmonary hypertension, Sci. Transl. Med, 3, 88ra55, 10.1126/scitranslmed.3002194

Szabadkai, 2008, Mitochondria: the hub of cellular Ca2+ signaling, Physiology (Bethesda), 23, 84, 10.1152/physiol.00046.2007

Tait, 2010, Mitochondria and cell death: outer membrane permeabilization and beyond, Nat. Rev. Mol. Cell Biol, 11, 621, 10.1038/nrm2952

Tait, 2013, Widespread mitochondrial depletion via mitophagy does not compromise necroptosis, Cell Rep, 5, 878, 10.1016/j.celrep.2013.10.034

Tian, 2012, Uncoupling protein-2 protects endothelial function in diet-induced obese mice, Circ. Res, 110, 1211, 10.1161/CIRCRESAHA.111.262170

Topal, 2006, Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells, J. Pharmacol. Exp. Ther, 318, 1368, 10.1124/jpet.106.103747

Trenker, 2007, Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport, Nat. Cell Biol, 9, 445, 10.1038/ncb1556

Trudeau, 2010, High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy, Am. J. Pathol, 177, 447, 10.2353/ajpath.2010.091029

Trudeau, 2012, Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome c release in retinal endothelial cells, Invest. Ophthalmol. Vis. Sci, 53, 6675, 10.1167/iovs.12-9895

Uberti, 2013, Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways, J. Clin. Endocrinol. Metab, 99, 1367, 10.1210/jc.2013-2103

Ungvari, 2008, Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats, Am. J. Physiol. Heart Circ. Physiol, 294, H2121, 10.1152/ajpheart.00012.2008

Ungvari, 2009, Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells, Am. J. Physiol. Heart Circ. Physiol, 297, H1876, 10.1152/ajpheart.00375.2009

Vaisman, 2012, Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice, PLoS ONE, 7, e39487, 10.1371/journal.pone.0039487

Vergeade, 2010, Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: prevention by the targeted antioxidant MitoQ, Free Radic. Biol. Med, 49, 748, 10.1016/j.freeradbiomed.2010.05.024

Waksman, 2003, Oral rapamycin inhibits growth of atherosclerotic plaque in apoE knock-out mice, Cardiovasc. Radiat. Med, 4, 34, 10.1016/S1522-1865(03)00121-5

Walter, 1998, Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria, Circulation, 98, 1153, 10.1161/01.CIR.98.12.1153

Wang, 2009, The role of mitochondria in apoptosis*, Annu. Rev. Genet, 43, 95, 10.1146/annurev-genet-102108-134850

Wang, 2011a, Maternally inherited essential hypertension is associated with the novel 4263AG mutation in the mitochondrial tRNAIle gene in a large han chinese family, Circ. Res, 108, 862, 10.1161/CIRCRESAHA.110.231811

Wang, 2012, Mitochondrial fission triggered by hyperglycemia is mediated by rock1 activation in podocytes and endothelial cells, Cell Metab, 15, 186, 10.1016/j.cmet.2012.01.009

Wang, 2011b, AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes, Am. J. Physiol. Endocrinol. Metab, 300, E1135, 10.1152/ajpendo.00001.2011

Wang, 2005, Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels, Int. J. Mol. Med, 16, 533

Westermann, 2010, Mitochondrial fusion and fission in cell life and death, Nat. Rev. Mol. Cell Biol, 11, 872, 10.1038/nrm3013

Widder, 2009, Attenuation of angiotensin II–induced vascular dysfunction and hypertension by overexpression of thioredoxin 2, Hypertension, 54, 338, 10.1161/HYPERTENSIONAHA.108.127928

Widlansky, 2011, Regulation of endothelial function by mitochondrial reactive oxygen species, Antioxid. Redox Signal, 15, 1517, 10.1089/ars.2010.3642

Won, 2010, Peroxisome proliferator-activated receptor-γ coactivator 1-α overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity, Arterioscler. Thromb. Vasc. Biol, 30, 290, 10.1161/ATVBAHA.109.198721

Xie, 2008, Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes, Diabetes, 57, 3222, 10.2337/db08-0610

Xiong, 2013, Peroxisome proliferator-activated receptor γcoactivator-1α is a central negative regulator of vascular senescence, Arterioscler. Thromb. Vasc. Biol, 33, 988, 10.1161/ATVBAHA.112.301019

Xu, 2007, Alterations of cellular bioenergetics in pulmonary artery endothelial cells, Proc. Natl. Acad. Sci. U.S.A, 104, 1342, 10.1073/pnas.0605080104

Yiu, 2011, Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes, J. Clin. Endocrinol. Metab, 96, E830, 10.1210/jc.2010-2212

Young, 1978, Caloric restriction lowers blood pressure in the spontaneously hypertensive rat, Metabolism, 27, 1711, 10.1016/0026-0495(78)90256-1

Yu, 2013, Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans, Circulation, 128, 702, 10.1161/CIRCULATIONAHA.113.002271

Yu, 2006, Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology, Proc. Natl. Acad. Sci. U.S.A, 103, 2653, 10.1073/pnas.0511154103

Yuen, 2012, eNOS deficiency predisposes podocytes to injury in diabetes, J. Am. Soc. Nephrol, 23, 1810, 10.1681/ASN.2011121170

Zhang, 2007, Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions, Am. J. Pathol, 170, 1108, 10.2353/ajpath.2007.060960

Zhang, 2002, Down-regulation of mitochondrial cytochrome c oxidase in senescent porcine pulmonary artery endothelial cells, Mech. Ageing Dev, 123, 1363, 10.1016/S0047-6374(02)00075-1

Zhang, 2008, Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice, Cardiovasc. Res, 80, 191, 10.1093/cvr/cvn224

Zhang, 2004, Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner, Circ. Res, 94, 1483, 10.1161/01.RES.0000130525.37646.a7

Zhou, 2011a, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663

Zhou, 2011b, Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction, Circ. Res, 109, 639, 10.1161/CIRCRESAHA.111.243592