Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling

Green DR, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309

Smaili SS, 2000, Mitochondria in Ca2+ signaling and apoptosis, Journal of Bioenergetics and Biomembranes, 32, 35, 10.1023/A:1005508311495

Marchetti P, 1996, Mitochondrial permeability transition triggers lymphocyte apoptosis, Journal of Immunology, 157, 4830, 10.4049/jimmunol.157.11.4830

Macho A, 1997, Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis, Journal of Immunology, 158, 4612, 10.4049/jimmunol.158.10.4612

Kroemer G, 1998, The mitochondrial death/life regulator in apoptosis and necrosis, Annual Review of Physiology, 60, 619, 10.1146/annurev.physiol.60.1.619

Du C, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8

Marzo I, 1998, Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis, Science, 281, 2027, 10.1126/science.281.5385.2027

Hoek JB, 1995, Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition, Biochimica et Biophysica Acta, 1271, 93, 10.1016/0925-4439(95)00015-V

Lehninger AL, 1978, Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides, Proceedings of the National Academy of Sciences, USA, 75, 1690, 10.1073/pnas.75.4.1690

Connern CP, 1992, Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophylin, Biochemical Journal, 284, 381, 10.1042/bj2840381

Halestrap AP, 1992, Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase, Journal of Biological Chemistry, 272, 3346, 10.1074/jbc.272.6.3346

Beutner G, 1998, Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore: Implication for regulation of permeability transition by the kinases, Biochimica et Biophysica Acta, 1368, 7, 10.1016/S0005-2736(97)00175-2

Kowaltowski AJ, 2001, Mitochondrial permeability transition and oxidative stress, FEBS Letters, 495, 12, 10.1016/S0014-5793(01)02316-X

Vercesi AE, 1997, The role of reactive oxygen species in mitochondrial permeability transition, Bioscience Reports, 17, 43, 10.1023/A:1027335217774

Smaili SS, 1999, Permeability transition pore regulates both mitochondrial membrane potential and agonist-evoked Ca2+ signals in oligodendrocyte progenitors, Cell Calcium, 26, 121, 10.1054/ceca.1999.0061

Smaili SS, 2001, Cyclosporin A inhibits inositol 1,4,5-trisphosphate-dependent Ca2+ signals by enhancing Ca2+ uptake into the endoplasmic reticulum and mitochondria, Journal of Biological Chemistry, 276, 23329, 10.1074/jbc.M100989200

Skulachev VP, 1997, Membrane-linked systems preventing superoxide formation, Bioscience Reports, 17, 347, 10.1023/A:1027344914565

Adams JM, 1998, The Bcl-2 protein family: arbiters of cell survival, Science, 281, 1322, 10.1126/science.281.5381.1322

Hsu YT, 1997, Cytosol-to-membrane redistribution of Bax and Bcl-X L during apoptosis, Proceedings of the National Academy of Sciences, USA, 94, 3668, 10.1073/pnas.94.8.3668

Krajewski S, 1994, Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2, American Journal of Pathology, 145, 1326

Li H, 1998, Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis, Cell, 94, 491, 10.1016/S0092-8674(00)81590-1

Muchmore SW, 1996, X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death, Nature, 381, 335, 10.1038/381335a0

Kagan BL, 1981, Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes, Proceedings of the National Academy of Sciences, USA, 78, 4950, 10.1073/pnas.78.8.4950

Schlesinger PH, 1997, Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2, Proceedings of the National Academy of Sciences, USA, 94, 11357, 10.1073/pnas.94.21.11357

Jurgensmeier JM, 1998, Bax directly induces release of cytochrome c from isolated mitochondria, Proceedings of the National Academy of Sciences, USA, 95, 4997, 10.1073/pnas.95.9.4997

Zou H, 1997, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, Cell, 90, 405, 10.1016/S0092-8674(00)80501-2

Li P, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1

Narita M, 1998, Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria, Proceedings of the National Academy of Sciences, USA, 95, 14681, 10.1073/pnas.95.25.14681

Goldstein JC, 2000, The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant, Nature Cell Biology, 2, 156, 10.1038/35004029

Eskes R, 1998, Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions, Journal of Cell Biology, 193, 217, 10.1083/jcb.143.1.217

Oltvai ZN, 1993, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell, 74, 609, 10.1016/0092-8674(93)90509-O

Yang E, 1996, Molecular apoptosis: a discourse on the Bcl-2 family and cell death, Blood, 88, 386, 10.1182/blood.V88.2.386.bloodjournal882386

Knudson CM, 1995, Bax-deficient mice with lymphoid hyperplasia and male germ cell death, Science, 270, 96, 10.1126/science.270.5233.96

Krajewski S, 1997, Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin, American Journal of Pathology, 150, 805

LeBlanc H, 2002, Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax, Nature Medicine, 8, 274, 10.1038/nm0302-274

Zha H, 1996, Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells, Molecular and Cellular Biology, 16, 6494, 10.1128/MCB.16.11.6494

Suzuki M, 2000, Structure of Bax: coregulation of dimer formation and intracellular localization, Cell, 103, 645, 10.1016/S0092-8674(00)00167-7

Smaili SS, 2001, Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential, Cell Death and Differentiation, 8, 909, 10.1038/sj.cdd.4400889

Nechushtan A, 1999, Conformation of the Bax C-terminus regulates subcellular location and cell death, EMBO Journal, 18, 2330, 10.1093/emboj/18.9.2330

Nechushtan A, 2001, Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis, Journal of Cell Biology, 153, 1265, 10.1083/jcb.153.6.1265

Antonsson BS, 2000, Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria, Biochemical Journal, 345, 271, 10.1042/bj3450271

Vander Heiden MG, 1997, Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria, Cell, 91, 627, 10.1016/S0092-8674(00)80450-X

Gross A, 1999, Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death, Journal of Biological Chemistry, 274, 1156, 10.1074/jbc.274.2.1156

Polster BM, 2001, BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability, Journal of Biological Chemistry, 276, 37887, 10.1074/jbc.M104552200

Korsmeyer SJ, 2000, Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c, Cell Death and Differentiation, 7, 1166, 10.1038/sj.cdd.4400783

Wei MC, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108

Mootha VK, 2001, A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c, EMBO Journal, 20, 661, 10.1093/emboj/20.4.661

Budd SL, 1998, Mechanisms of neuronal damage in brain hypoxia/ischemia: focus on the role of mitochondrial calcium accumulation, Pharmacology and Therapeutics, 80, 203, 10.1016/S0163-7258(98)00029-1

Dubinsky JM, 1998, Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons, Journal of Neuroscience Research, 53, 728, 10.1002/(SICI)1097-4547(19980915)53:6<728::AID-JNR10>3.0.CO;2-U

Castilho RF, 1998, Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells, Journal of Neuroscience, 18, 10277, 10.1523/JNEUROSCI.18-24-10277.1998

Gunter TE, 1998, The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients, Biochimica et Biophysica Acta, 1366, 5, 10.1016/S0005-2728(98)00117-0

Baysal K, 1994, Na+-dependent Ca2+ efflux mechanism of heart mitochondria is not a passive Ca2+/2Na+ exchanger, American Journal of Physiology, 266, C800, 10.1152/ajpcell.1994.266.3.C800

McConkey DJ, 1997, The role of calcium in the regulation of apoptosis, Biochemical and Biophysical Research Communications, 239, 357, 10.1006/bbrc.1997.7409

Nutt LK, 2002, Bax and bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores, Journal of Biological Chemistry, 277, 9219, 10.1074/jbc.M106817200

Pacher P, 2001, Mitochondrial Ca2+ signaling and cardiac apoptosis, Biological Signals and Receptors, 10, 200, 10.1159/000046888

Baffy G, 1993, Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production, Journal of Biological Chemistry, 268, 6511, 10.1016/S0021-9258(18)53280-4

Pan Z, 2001, Synergistic movements of Ca(2+) and Bax in cells undergoing apoptosis, Journal of Biological Chemistry, 276, 32257, 10.1074/jbc.M100178200

Dubrez L, 2001, Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein, Journal of Biological Chemistry, 276, 38980, 10.1074/jbc.M102683200

Csordas G, 2002, tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane, EMBO Journal, 21, 2198, 10.1093/emboj/21.9.2198

Scorrano L, 2002, A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis, Developmental Cell, 2, 55, 10.1016/S1534-5807(01)00116-2