Mimosine Arrests Proliferating Human Cells before Onset of DNA Replication in a Dose-Dependent Manner

Johnson, 1993 Lalande, 1990, A reversible arrest point in the late G1 phase of the mammalian cell cycle, Exp. Cell Res., 186, 332, 10.1016/0014-4827(90)90313-Y Hoffman, 1991, A new class of reversible cell cycle inhibitors, Cytometry, 12, 26, 10.1002/cyto.990120105 Watson, 1991, Mimosine reversibly arrests cell cycle progression at the G1-S phase border, Cytometry, 12, 242, 10.1002/cyto.990120306 Dijkwel, 1992, Initiation of DNA replication in the dihydrofolate reductase locus is confined to the early S period in CHO cells synchronized with the plant amino acid mimosine, Mol. Cell. Biol., 12, 3715 Mosca, 1992, The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells, Mol. Cell. Biol., 12, 4375 Levenson, 1993, A general protocol for evaluating the specific effects of DNA replication inhibitors, Nucleic Acids Res., 21, 3997, 10.1093/nar/21.17.3997 Hughes, 1996, Mimosine arrests the cell cycle after cells enter S-phase, Exp. Cell Res., 222, 275, 10.1006/excr.1996.0035 Gilbert, 1995, Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism, J. Biol. Chem., 270, 9597, 10.1074/jbc.270.16.9597 Dai, 1994, Mimosine inhibits viral DNA synthesis through ribonucleotide reductase, Virology, 205, 210, 10.1006/viro.1994.1636 Kalejta, 1997, The dual effect of mimosine on DNA replication, Exp. Cell Res., 231, 173, 10.1006/excr.1996.3444 Reichard, 1993, From RNA to DNA, why so many ribonucleotide reductases, Science, 260, 1773, 10.1126/science.8511586 Tsai, 1971, Toxic action of mimosine. I. Inhibition of mitosis and DNA synthesis of H.Ep-2 cell by mimosine and 3,4-dihydroxypyridine, Toxicon, 9, 241, 10.1016/0041-0101(71)90076-6 Wang, 1995, Mimosine differentially inhibits DNA replication and cell cycle progression in somatic cells compared to embryonic cells of Xenopus laevis, Exp. Cell Res., 217, 84, 10.1006/excr.1995.1066 Tsvetkov, 1997, Effect of mimosine on DNA synthesis in mammalian cells, Cancer Res., 57, 2252 Krude, 1997, Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system, Cell, 88, 109, 10.1016/S0092-8674(00)81863-2 Gurdon, 1976, Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal, J. Embryol. Exp. Morphol., 36, 523 Krude, 1995, Chromatin assembly factor 1 (CAF-1) colocalizes with replication foci in HeLa cell nuclei, Exp. Cell Res., 220, 304, 10.1006/excr.1995.1320 Vogt, 1993, Mimosine, a naturally occurring drug interfering primarily with the cell nucleus, J. Submicrosc. Cytol. Pathol., 25, 247 Vogt, 1994, Mimosine-induced cell death and related chromatin changes, J. Submicrosc. Cytol. Pathol., 26, 319 Jackson, 1986, Replication occurs at a nucleoskeleton, EMBO J., 5, 1403, 10.1002/j.1460-2075.1986.tb04374.x Jackson, 1986, A cell-cycle-dependent DNA polymerase activity that replicates intact DNA in chromatin, J. Mol. Biol., 192, 65, 10.1016/0022-2836(86)90464-X Hassan, 1993, Visualization of replication sites in unfixed human cells, J. Cell Sci., 105, 541, 10.1242/jcs.105.2.541 Hozak, 1993, Visualization of replication factories attached to nucleoskeleton, Cell, 73, 361, 10.1016/0092-8674(93)90235-I Hand, 1978, Eukaryotic DNA: Organization of the genome for replication, Cell, 15, 317, 10.1016/0092-8674(78)90001-6 Jha, 1995, Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary or transformed human lymphocytes, Mutagenesis, 10, 385, 10.1093/mutage/10.5.385 Mosca, 1995, Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells, Nucleic Acids Res., 23, 261, 10.1093/nar/23.2.261 Lin, 1996, Mimosine targets serine hydroxymethyltransferase, J. Biol. Chem., 271, 2548, 10.1074/jbc.271.5.2548 Pasero, 1998, New systems for replicating DNA in vitro, Curr. Opin. Cell. Biol., 10, 304, 10.1016/S0955-0674(98)80004-5 Pasero, 1997, ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei, Genes Dev., 11, 1504, 10.1101/gad.11.12.1504