Mildronate exerts acute anticonvulsant and antihypnotic effects

Augustyniak, 2009, L-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress, Alcohol, 43, 217, 10.1016/j.alcohol.2008.12.005

Binienda, 2005, L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction, Ann N Y Acad Sci, 1053, 174, 10.1196/annals.1344.015

Corda, 1991, Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors, Pharmacol Biochem Behav, 40, 329, 10.1016/0091-3057(91)90562-G

Cremer, 2009, Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain, Neuroscience, 163, 490, 10.1016/j.neuroscience.2009.03.068

Dambrova, 2002, Mildronate: cardioprotective action through carnitine-lowering effect, Trends Cardiovasc Med, 12, 275, 10.1016/S1050-1738(02)00175-5

Dambrova, 2008, Effect of inhibiting carnitine biosynthesis on male rat sexual performance, Physiol Behav, 95, 341, 10.1016/j.physbeh.2008.06.012

De Sarro, 1991, Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex, Fundam Clin Pharmacol, 5, 503, 10.1111/j.1472-8206.1991.tb00737.x

Draski, 1993, Initial effects of ethanol on the central nervous system. Pharmacological Effects of Ethanol on the Nervous System, 227

Dziak, 2003, Use of mildronate for the treatment of patients with circulatory encephalopathy against a background of stenosis of major arteries of the head, Lik Sprava, 5–6, 98

Dzintare, 2002, Involvement of nitric oxide production in the mildronate mechanism of action, Pharmacology Reviews and Communications, 12, 163, 10.1080/10604450213832

Fariello, 1981, Competitive inhibition by 3-aminopropanesulfonic acid and gamma-aminobutyric acid of carnitine transport in rat brain slices, Biochem Pharmacol, 30, 1012, 10.1016/0006-2952(81)90049-6

Foster, 2004, The role of the carnitine system in human metabolism, Ann N Y Acad Sci, 1033, 1, 10.1196/annals.1320.001

Golovacheva, 2006, Neuroprotective treatment of patients with normal tension glaucoma, Georgian Med News, 131, 37

Homayoun, 2002, The role of nitric oxide in anticonvulsant and proconvulsant effects of morphine in mice, Epilepsy Res, 48, 33, 10.1016/S0920-1211(01)00316-3

Jones, 2010, Acylcarnitines: role in brain, Prog Lipid Res, 49, 61, 10.1016/j.plipres.2009.08.004

Koudelova, 1994, Protective effect of carnitine on lipoperoxide formation in rat brain, Physiol Res, 43, 387

Kuwajima, 1999, Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2,2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney, J Pharmacol Exp Ther, 289, 93

Liepinsh, 2006, Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction, J Cardiovasc Pharmacol, 48, 314, 10.1097/01.fjc.0000250077.07702.23

Liepinsh, 2008, Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart, Life Sci, 83, 613, 10.1016/j.lfs.2008.08.008

Liepinsh, 2009a, Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats, Br J Pharmacol, 157, 1549, 10.1111/j.1476-5381.2009.00319.x

Liepinsh, 2009b, Effects of long-term mildronate treatment on cardiac and liver functions in rats, Basic Clin Pharmacol Toxicol, 105, 387, 10.1111/j.1742-7843.2009.00461.x

Loscher, 1991, The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models, Epilepsy Res, 8, 171, 10.1016/0920-1211(91)90062-K

Mandhane, 2007, Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice, Seizure, 16, 636, 10.1016/j.seizure.2007.05.005

Maresova, 2001, Carnitine pretreatment can partially change the excitability of the immature nervous tissue, Physiol Res, 50, 439

Matsuoka, 1992, Preservation of energy metabolites by carnitine in the mouse brain under ischemia, Brain Res, 590, 334, 10.1016/0006-8993(92)91117-W

Meldrum, 1975, Epilepsy and gamma-aminobutyric acid-mediated inhibition, Int Rev Neurobiol, 17, 1, 10.1016/S0074-7742(08)60205-6

Nidhi, 1999, Role of nitric oxide in electroshock and pentylenetetrazole seizure threshold in rats, Methods Find Exp Clin Pharmacol, 21, 609, 10.1358/mf.1999.21.9.795611

Psarropoulou, 1994, Pentylenetetrazol-induced seizures decrease gamma-aminobutyric acid-mediated recurrent inhibition and enhance adenosine-mediated depression, Epilepsia, 35, 12, 10.1111/j.1528-1157.1994.tb02906.x

Riazi, 2006, The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway, Br J Pharmacol, 147, 935, 10.1038/sj.bjp.0706680

Sakvarelidze, 2006, Change of concentration of L-carnitine in blood and other tissues in rats on a background of the alcohol intake and influence of mildronate on its level, Georgian Med News, 137, 94

Simkhovich, 1988, 3-(2,2,2-Trimethylhydrazinium)propionate (THP) a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties, Biochem Pharmacol, 37, 195, 10.1016/0006-2952(88)90717-4

Sizova, 2002, The role of endogenous modulators of chemoreactivity in the regulation of coronary blood flow, Ross Fiziol Zh Im I M Sechenova, 88, 856

Sjakste, 2005, Mildronate: an antiischemic drug for neurological indications, CNS Drug Rev, 11, 151, 10.1111/j.1527-3458.2005.tb00267.x

Starr, 1993, Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME, Pharmacol Biochem Behav, 45, 321, 10.1016/0091-3057(93)90246-P

Statsenko, 2008, Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy, Ter Arkh, 80, 27

Szot, 2004, The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors, Neuroscience, 126, 795, 10.1016/j.neuroscience.2004.04.030

Takada, 2001, Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats, Stroke, 32, 1216, 10.1161/01.STR.32.5.1216

Tsuda, 1997, Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice, Life Sci, 60, 339, 10.1016/S0024-3205(97)00226-9

Vinichuk, 1991, The efficacy of the mildronate treatment of patients with ischemic stroke, Vrach Delo, 7, 77

Yu, 1997, Suppression of pentylenetetrazol-induced seizures by carnitine in mice, Naunyn Schmiedebergs Arch Pharmacol, 355, 545, 10.1007/PL00004981