Mild moxibustion plus loratadine tablets for children with allergic rhinitis: a randomized controlled trial
Tóm tắt
To explore the efficacy of mild moxibustion plus loratadine tablets for children with allergic rhinitis (AR). A total of 80 children were randomized into a control group and an observation group, with 40 cases in each group. The control group was treated with loratadine tablets, and the observation group was treated with mild moxibustion plus loratadine tablets. Before and after treatment, the total nasal symptom score (TNSS) was evaluated, and the serum eosinophils (EOS) count, and the interleukin (IL)-27 and macrophage migration inhibitory factor (MIF) levels were measured. Clinical efficacy was evaluated after treatment. The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the TNSS in both groups decreased (P<0.05), and the TNSS in the observation group was lower than that in the control group (P<0.05); the serum EOS count in both groups decreased (P<0.05), and the serum EOS count in the observation group was lower than that in the control group (P<0.05). The serum IL-27 level in the control group had no statistical difference compared with the same group before treatment (P>0.05), and the serum MIF level decreased after treatment (P<0.05). The serum IL-27 level in the observation group increased after treatment (P<0.05), and the serum MIF level decreased after treatment (P<0.05), and were both statistically different from those in the control group (P<0.05). Mild moxibustion plus loratadine tablets is effective in treating children with AR. It can significantly improve the nasal symptoms and reduce the serum EOS count, which may be related to the regulation of the serum IL-27 and MIF levels.
Tài liệu tham khảo
Kakli HA, Riley TD. Allergic rhinitis. Prim Care, 2016, 43(3): 465–475.
Pediatric Otolaryngology Committee of China Pediatric Association, Chinese Medical Doctor Association. Clinical practice guideline: diagnosis and treatment in children with allergic rhinitis. Zhongguo Shiyong Erke Zazhi, 2019, 34(3): 169–175.
Schuler Iv CF, Montejo JM. Allergic rhinitis in children and adolescents. Pediatr Clin North Am, 2019, 66(5): 981–993.
Bernstein DI, Schwartz G, Bernstein JA. Allergic rhinitis: mechanisms and treatment. Immunol Allergy Clin North Am, 2016, 36(2): 261–278.
Wang W, Xing XL, Liu WR, Sun YX, Du MR. Effect of Yiqi Yangyin recipe combined with acupoint application on patients with allergic rhinitis. Hebei Zhongyi, 2019, 41(12): 1795–1798.
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of allergic rhinitis (2015, Tianjin). Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2016, 51(1): 6–24.
Wang SC, Li H, Xu L. Clinical guidelines for diagnosis and treatment of pediatric diseases in Chinese medicine: allergic rhinitis in children. Zhonghua Zhongyiyao Zazhi, 2016, 31(4): 1352–1355.
Zhang HY, Lu SF, Xiao N. Effects of mild warming moxibustion on acupoints Shenque (CV 8) and Guanyuan (CV 4) for prevention and treatment of recurrent respiratory tract infection in children with cerebral palsy. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2010, 30(9): 935–937.
Banerjee K, Mathie RT, Costelloe C, Howick J. Homeopathy for allergic rhinitis: a systematic review. J Altern Complement Med, 2017, 23(6): 426–444.
Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Chinese Otorhinolaryngology Society of Chinese Medical Association. Diagnostic and treatment principle for allergic rhinitis and a recommended scheme (2004, Lanzhou). Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005, 40(3): 166–167.
Duse M, Donato F, Porteri V, Pirali F, Spinoni V, Tosoni C, Vettore M, Lombardi C. High prevalence of atopy, but not of asthma, among children in an industrialized area in North Italy: the role of familial and environmental factors-a population-based study. Pediatr Allergy Immunol, 2007, 18(3): 201–208.
Klimek L, Pfaar O, Bousquet J, Senti G, Kündig T. Allergen immunotherapy in allergic rhinitis: current use and future trends. Expert Rev Clin Immunol, 2017, 13(9): 897–906.
Dunlop J, Matsui E, Sharma HP. Allergic rhinitis: environmental determinants. Immunol Allergy Clin North Am, 2016, 36(2): 367–377.
Fu S, Ni S, Wang D, Hong T. Coptisine suppresses mast cell degranulation and ovalbumin-induced allergic rhinitis. Molecules, 2018, 23(11): 3039.
Liu W, Zeng Q, Chen Y, Luo RZ. Role of leptin/osteopontin axis in the function of eosinophils in allergic rhinitis with obesity. Mediators Inflamm, 2018, 2018: 9138904.
Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy, 2019, 74(5): 910–921.
Bui TT, Kwon DA, Choi DW, Jung SY, Lee SY, Piao CH, Hyeon E, Fan Y, Yeon SH, Son RH, Shon DH, Song CH, Shin HS, Chai OH. Rosae multiflorae fructus extract and its four active components alleviate ovalbumin-induced allergic inflammatory responses via regulation of Th1/Th2 imbalance in BALB/c rhinitis mice. Phytomedicine, 2019, 55: 238–248.
Ni K, Zhao L, Wu J, Chen W, Yang HY, Li X. Th17/Treg balance in children with obstructive sleep apnea syndrome and the relationship with allergic rhinitis. Int J Pediatr Otorhinolaryngol, 2015, 79(9): 1448–1454.
Yang FW, Chen XM, Zhang X, Li JZ, Chen H. Expression and clinical significance of IL-27, IL-17 and IL-10 in serum of patients with allergic rhinitis. Xiandai Shengwu Yixue Jinzhan, 2018, 18(1): 126–129.
Bozza MT, Lintomen L, Kitoko JZ, Paiva CN, Olsen PC. The role of MIF on eosinophil biology and eosinophilic inflammation. Clin Rev Allergy Immunol, 2020, 58(1): 15–24.
Nakamaru Y, Oridate N, Nishihira J, Takagi D, Furuta Y, Fukuda S. Macrophage migration inhibitory factor (MIF) contributes to the development of allergic rhinitis. Cytokine, 2005, 31(2): 103–108.
Ma HJ. The Expression and Role of MIF, NF-κB and IL-1β in Nasal Polyps. Zhengzhou: Master Thesis of Zhengzhou University, 2014.
Nayak AS, Berger WE, LaForce CF, Urdaneta ER, Patel MK, Franklin KB, Wu MM. Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc, 2017, 38(3): 222–230.
Shi L, Zhang SJ, Hu Y. Discussion on the causes of allergic rhinitis in traditional Chinese medicine. Zhongyi Wenxian Zazhi, 2019, 37(6): 18–19.
Huang HY, Zhang QX, Zhong J, Jiang LY, Mou Y, Fu L, He HS, Wu XJ, Lan JB. Study on the distribution of 8 TCM syndromes in 1 216 children with allergic rhinitis in Chengdu area. Shizhen Guoyi Guoyao, 2019, 30(10): 2515–2518.