Mild Cobalt(III)‐Catalyzed C–H Hydroarylation of Conjugated C=C/C=O Bonds

Advanced Synthesis and Catalysis - Tập 359 Số 10 - Trang 1717-1724 - 2017
Jie Li1, Ziqi Zhao1,2, Wenbo Ma3,2, Mengyao Tang1, Dawei Wang4, Liang‐Hua Zou1
1School of Pharmaceutical Sciences, Jiangnan University., Lihu Road 1800, 214122 Wuxi, Jiangsu, People's Republic of China
2Z.Z. and W.M. contributed equally to this work.
3Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 610052 Chengdu, Sichuan, People's Republic of China
4The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Lihu Road 1800, 214122 Wuxi, Jiangsu, People's Republic of China

Tóm tắt

AbstractAn efficient cobalt(III)‐catalyzed C‐2‐selective indole C–H hydroarylation of acrolein, enones, and glyoxylates was achieved under mild reaction conditions. The versatile cobalt(III) catalyst displayed excellent positional selectivity with the assistance of pyrimidinyl, pyridyl, and pyrazolyl directing groups, thus overcoming the inherent C‐3 selectivity of an electrophilic indole derivatization. This approach provides an expedient route to indolyl‐substituted aldehydes, ketones, and esters with wide functional group tolerance. In addition, it also features high step‐ and atom‐economy.magnified image

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Advanced Synthesis and Catalysis

Tập 359 Số 10

1717-1724

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