Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Cell Stem Cell - Tập 19 - Trang 248-257 - 2016
Junghyun Jo1, Yixin Xiao2,3, Alfred Xuyang Sun1,4, Engin Cukuroglu1, Hoang-Dai Tran1,5, Jonathan Göke1, Zi Ying Tan1,6, Tzuen Yih Saw1, Cheng-Peow Tan1, Hidayat Lokman2, Younghwan Lee2, Donghoon Kim7, Han Seok Ko7, Seong-Oh Kim8, Jae Hyeon Park8, Nam-Joon Cho8,9, Thomas M. Hyde10,11,12, Joel E. Kleinman10,11, Joo Heon Shin10, Daniel R. Weinberger10,11,12,13,14
1Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
2Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore
3Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
4National Neuroscience Institute, 20 College Road, Singapore 169856, Singapore
5Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
6Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
7Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
8School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
9KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Korea
10The Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA
11Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
12Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
13Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
14McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Cell Stem Cell

Tập 19

248-257

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