Microwave Multicomponent Synthesis

Loupy, A. (2006). Microwaves in Organic Synthesis, Wiley-VCH Verlag GmbH & Co. KGaA.

Kappe, 2004, Controlled microwave heating in modern organic synthesis, Angew. Chem. Int. Ed., 43, 6250, 10.1002/anie.200400655

Bagley, 2006, Microwave-assisted multicomponent reactions for the synthesis of heterocycles, Top Heterocycl. Chem., 1, 31, 10.1007/7081_004

Wannberg, 2005, Microwave-enhanced and metal-catalyzed functionalisations of the 4-aryl-dihydropyrimidone template, J. Comb. Chem., 7, 574, 10.1021/cc049816c

Sujatha, 2006, Synthesis and cardiac effects of 3,4-dihydropyrimidin-2-(1H)-one-5 Carboxylates, Bioorg. Med. Chem. Lett., 16, 4893, 10.1016/j.bmcl.2006.06.059

Khabazzadeh, 2008, Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst, Bioorg. Med. Chem. Lett., 18, 278, 10.1016/j.bmcl.2007.10.087

Matloobi, 2007, Microwave-assisted solution- and solid-phase synthesis of 2-amino-4-arylpyrimidine derivatives, J. Comb. Chem., 9, 275, 10.1021/cc0601377

Akba, 2008, Studies on reactions of Pyrimidine Compounds. 2. Microwave-assisted synthesis of 1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives, Phosphorous, Sulfur Silicon Relat. Elem., 183, 82, 10.1080/10426500701557021

Ostras, 2006, An easy access to 2-Amino-5,6-dihydro-3H-pyrimidin-4-one building blocks: The reaction under conventional and microwave conditions, Mol. Divers., 10, 483, 10.1007/s11030-006-9045-1

Pisani, 2007, 5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques, J. Comb. Chem., 9, 415, 10.1021/cc0700041

Kolosov, 2009, A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis, Mol. Divers., 13, 5, 10.1007/s11030-008-9094-8

Legeay, 2005, Ionic liquid phase technology supported the three component synthesis of Hantzsch 1,4-dihydropyridines and Biginelli 3,4-dihydropyrimidin-2(1H)-ones under microwave heating, Tetrahedron, 61, 12386, 10.1016/j.tet.2005.09.118

Chebanov, 2008, Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes, J. Org. Chem., 73, 5110, 10.1021/jo800825c

Chebanov, 2007, One-pot, multicomponent route to pyrazoloquinolizinones, Org. Lett., 9, 1691, 10.1021/ol070411l

Glasnov, 2008, Integration of high speed microwave chemistry and a statistical ‘design of experiment’ approach for the synthesis of the mitotic kinesin Eg5 inhibitor Monastrol, Tetrahedron, 64, 2035, 10.1016/j.tet.2007.12.056

Demare, 2008, Application of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane derivatives in asymmetric organic catalysis: the Biginelli reaction, ARKIVOC, vi, 61

Santra, 2007, A One-pot, microwave-influenced synthesis of diverse small molecules by multicomonent reaction cascades, Org. Lett., 9, 5035, 10.1021/ol702256t

Santra, 2008, A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-terahydro-1,4-benzodiazepin-3-ones, Org. Lett., 10, 4541, 10.1021/ol801841m

DiMauro, 2007, Rapid synthesis of 3-amino-imidazopyridines by a microwave-assisted four-component coupling in one-pot, J. Org. Chem., 72, 1013, 10.1021/jo0622072

Xing, 2006, Microwave-assisted one-pot U-4CR and intramolecular O-alkylation toward heterocyclic scaffolds, Tetrahedron, 62, 6774, 10.1016/j.tet.2006.05.001

Hulme, 2009, An efficient solution phase synthesis of triazdibenzoazulenones: ‘designer isonitrile free’ methodology enabled by microwaves, Tetrahedron Lett., 50, 1939, 10.1016/j.tetlet.2009.02.099

Hulme, 2009, A simple, cheap alternative to ‘Designer convertible isonitriles’ expedited with microwaves, Tetrahedron Lett., 50, 4054, 10.1016/j.tetlet.2009.04.095

Bremner, 2007, Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis, J. Comb. Chem., 9, 14, 10.1021/cc060130p

Sakal, 2009, Nickel nanoparticle-catalyzed facile and efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation under solvent-free conditions, Tetrahedron Lett., 50, 1754, 10.1016/j.tetlet.2009.01.140

Zhu, 2008, Facile and efficient synthesis of a new class of bis(3’-indolyl)pyridine derivatives via one-pot multicomponent reactions, Tetrahedron Lett., 49, 1777, 10.1016/j.tetlet.2008.01.054

Zhu, 2008, Multicomponent reactions for the synthesis of new 3’-indolyl substituted heterocycles under microwave irradiation, Tetrahedron Lett., 49, 2578, 10.1016/j.tetlet.2008.02.101

Tu, 2009, Synthesis of isoxaolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water, J. Comb. Chem., 11, 428, 10.1021/cc800212v

Tu, 2007, A simple synthesis of fuoro[3’,4’:5,6]pyrido[2,3-d]pyrimidine derivatives through multicomponent reactions in water, Eur. J. Org. Chem., 38, 1522, 10.1002/ejoc.200600913

Dondoni, 2007, Hantzsch-type three-component approach to a new family of carbon-linked glycosyl amino acids. synthesis of c-glycosylmethyl pyridylalanines, J. Org. Chem., 72, 7677, 10.1021/jo071221r

Li, 2008, Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step mlticomponent reaction followed by a s-alkylation, J. Comb. Chem., 10, 436, 10.1021/cc700194b

Tu, 2009, Design and microwave-assisted synthesis of naphth[2,3-f]quinoline derivatives and their luminescent properties, J. Comb. Chem., 11, 239, 10.1021/cc800094m

Tu, 2007, Microwave-assisted combinatorial synthesis of polysubstituent imidazo[1,2-a]quinoline, pyrimido[1,2-a]quinoline and quinolino[1,2-a]quinazoline derivatives, J. Comb. Chem., 9, 1144, 10.1021/cc700124g

Liu, 2005, Three-component one-pot total synthesis of glyantrypine, fumiquinazoline f, and fiscalin b promoted by microwave irradiation, J. Org. Chem., 70, 6339, 10.1021/jo0508043

Liu, 2005, Microwave-assisted concise total syntheses of quinazolinobenzodiazepine alkaloids, J. Org. Chem., 70, 10488, 10.1021/jo051876x

Liu, 2005, Novel one-pot total synthesis of deoxyvasicinone, mackinazolinone, isaindigotone, and their dervatives promoted by microwave irradiation, Org. Lett., 7, 3363, 10.1021/ol0513084

Mont, 2008, Diversity oriented microwave-assisted synthesis of (-)-steganacin aza-analogues, J. Org. Chem., 73, 7509, 10.1021/jo801290j

Sunderhaus, 2007, Applications of multicomponent reactions for the synthesis of diverse heterocyclic scaffolds, Org. Lett., 9, 4223, 10.1021/ol7018357

2005, Parallel Microwave-assisted library of imidazothiazol-3-ones and imidazothiazin-4-ones, J. Comb. Chem., 7, 947, 10.1021/cc0500856

Tu, 2007, An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction, Org. Biomol. Chem., 5, 355, 10.1039/B614747J

Cui, 2005, Parallel synthesis of strongly fluorescent polysubstituted 2,6-dicyanoanilines via microwave-promoted multicomponent reaction, J. Org. Chem., 70, 2866, 10.1021/jo047823h

Ye, 2006, Novel and expeditious microwave-assisted three-component reactions for the synthesis of spiroimidazolin-4-ones, J. Org. Chem., 71, 3137, 10.1021/jo060228q

Gelens, 2006, Efficient library synthesis of imidazoles using a multicomonent reaction and microwave irradiation, Mol. Divers., 10, 17, 10.1007/s11030-006-8695-3

Werner, 2009, Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library, J. Comb. Chem., 11, 452, 10.1021/cc900003q

Sakhno, 2008, Multicomponent cyclocondensation reactions of aminoazoles, arylpyruvic acids and aldehydes with controlled chemoselectivity, Tetrahedron, 64, 11041, 10.1016/j.tet.2008.09.089

Ohta, 2009, Facile synthesis of 1,2,3,4-tetrahydro-b-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization, Org. Lett., 11, 1979, 10.1021/ol900460m

Jensen, 2009, Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1, J. Med. Chem., 52, 912, 10.1021/jm8013458

Surpur, 2009, Exploitation of the catalytic efficacy of Mg/Al hydrocalcite for the rapid synthesis of 2-aminochromene derivatives via a multicomponent strategy in the presence of microwaves, Tetrahedron Lett., 50, 719, 10.1016/j.tetlet.2008.11.114

Sridhar, 2009, Novel ZnCl2-catalyzed one-pot multicomponent synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines, Tetrahedron Lett., 50, 3897, 10.1016/j.tetlet.2009.04.051

Evdokimov, 2007, One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomonent reaction of malononitrile with aldehydes and thiols, J. Org. Chem., 72, 3443, 10.1021/jo070114u

Zhou, 2009, Facile one-pot, multicomponent synthesis of pyridines under microwave irradiation, Synth. Commun., 39, 1443, 10.1080/00397910802531930

Zhu, 2009, Microwave-assisted synthesis of new spiro[indoline-3,4’-quinoline] derivatives via a one-pot multicomonent reaction, Synth. Commun., 39, 1355, 10.1080/00397910802527714

Hatamjafari, 2006, New protocol to synthesize spiro-1,4-dihydropyridines by using a multicomponent reaction of cyclohexanone, ethyl cyanoacetate, isatin, and primary amines under microwave irradiation, Synth. Commun., 36, 3563, 10.1080/00397910600943543

Tu, 2009, An efficient and chemoselective synthesis of benzo[e][1,4]thiazepin-2-(1H,3H,5H)-ones via a microwave-assisted multi-component reaction in water, Org. Biomol. Chem., 7, 557, 10.1039/b815879g

Hao, 2009, Microwave-assisted combinatorial synthesis of new 3-pyrimidin-5-ylpropanamides via a solvent-dependent chemoselective reaction, J. Comb. Chem., 11, 310, 10.1021/cc800175n

Wen, 2008, Application of β-(2-Chloroaroyl) Thioacetanilides in Synthesis: An Unusual and Highly Efficient Access to Thiochromeno[2,3-b]pyridine Derivatives, J. Org. Chem., 73, 1852, 10.1021/jo7024702

Chavez, 2008, An efficient synthesis of Embelin derivatives through domino Knoevenagel hetero Diels-Alder reactions under microwave irradiation, Tetrahedron, 64, 8938, 10.1016/j.tet.2008.06.057

Defant, 2008, ChemInform Abstract: Microwave-Assisted Multicomponent Synthesis of Aza-, Diaza-, Benzo-, and Dibenzofluorenedione Derivatives, Synth. Commun., 38, 3003, 10.1080/00397910802044249

Castagnolo, 2009, One-pot multicomponent synthesis of 2,3-dihydropyrans: new access to furanose-pyranose 1,3-C-C-linked-dissacharides, Tetrahedron Lett., 50, 1526, 10.1016/j.tetlet.2009.01.047

Gising, 2009, A straightforward microwave method for rapid synthesis of N-1, C-6 functionalised 3,5-dichloro-2(1H)-pyrazinones, Org. Biomol. Chem., 7, 2809, 10.1039/b905501k