Microvessels in Chronic Total Occlusions: Pathways for Successful Guidewire Crossing?

Journal of Interventional Cardiology - Tập 18 Số 6 - Trang 425-436 - 2005
Bradley H. Strauss1, Amit Segev2, Graham A. Wright3,4, Beiping Qiang1, Nigel R. Munce3, Kevan Anderson3, General Leung3, Alexander Dick4, Renu Virmani5, Jagdish Butany6
1The Roy and Ann Foss Cardiovascular Research Program, Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, Ontario, Canada.
2Sheba Medical Center, Tel Aviv, Israel
3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
4Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada
5CV Path, Gaithersburg, Maryland
6University Health Network, Toronto, Ontario, Canada

Tóm tắt

Arterial chronic total occlusions (CTO) are a common and clinically relevant problem in patients with coronary artery disease. Percutaneous coronary intervention (PCI) success rates in a wide range of CTO are low, primarily due to inability of guidewire crossing. The pathophysiology of CTO is poorly understood and limits our ability to introduce innovative therapies. Recent studies from our laboratory have suggested that microvessel formation within arterial CTO is a complex process with temporal and regional differences. Moreover, there is evidence from pilot studies that the presence of either microvessels or the particular extracellular matrix environment in the adjacent perivascular tissue can facilitate guidewire crossing and successful PCI. Currently, studies are underway in our experimental CTO model to delineate the pathophysiology of microvessel formation in CTO and its potential role in PCI.

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Journal of Interventional Cardiology

Tập 18 Số 6

425-436

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