Microtubules and Their Role in Cellular Stress in Cancer

Amelia L. Parker1, Maria Kavallaris1, Joshua A. McCarroll1
1Tumour Biology and Targeting Program, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Australia

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Nogales, 2000, Structural insights into microtubule function, Annu Rev Biochem, 69, 277, 10.1146/annurev.biochem.69.1.277

Downing, 1998, Tubulin structure: insights into microtubule properties and functions, Curr Opin Struct Biol, 8, 785, 10.1016/S0959-440X(98)80099-7

Jordan, 2004, Microtubules as a target for anticancer drugs, Nat Rev Cancer, 4, 253, 10.1038/nrc1317

Veldhoen, 2013, The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis, Oncogene, 32, 736, 10.1038/onc.2012.92

Wang, 2009, Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response, J Cell Mol Med, 13, 3888, 10.1111/j.1582-4934.2009.00873.x

Xi, 2011, Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells, Cancer Lett, 307, 141, 10.1016/j.canlet.2011.03.026

Luduena, 1993, Are tubulin isotypes functionally significant, Mol Biol Cell, 4, 445, 10.1091/mbc.4.5.445

Sullivan, 1986, Identification of conserved isotype-defining variable region sequences for 4 vertebrate beta-tubulin polypeptide classes, Proc Natl Acad Sci U S A, 83, 4327, 10.1073/pnas.83.12.4327

Janke, 2011, Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions, Nat Rev Mol Cell Biol, 12, 773, 10.1038/nrm3227

Kavallaris, 2001, Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells, Cancer Res, 61, 5803

Martello, 2003, Elevated levels of microtubule destabilizing factors in a taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation, Cancer Res, 63, 1207

Verdier-Pinard, 2003, Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry, Biochemistry, 42, 5349, 10.1021/bi027293o

Mozzetti, 2005, Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients, Clin Cancer Res, 11, 298, 10.1158/1078-0432.298.11.1

Sale, 2002, Conservation of the class I beta-tubulin gene in human populations and lack of mutations in lung cancers and paclitaxel-resistant ovarian cancers, Mol Cancer Ther, 1, 215

Kavallaris, 2010, Microtubules and resistance to tubulin-binding agents, Nat Rev Cancer, 10, 194, 10.1038/nrc2803

Ferrandina, 2006, Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients, Clin Cancer Res, 12, 2774, 10.1158/1078-0432.CCR-05-2715

Lee, 2007, Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia, Histopathology, 51, 539, 10.1111/j.1365-2559.2007.02792.x

McCarroll, 2010, Beta III-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer, Cancer Res, 70, 4995, 10.1158/0008-5472.CAN-09-4487

Gan, 2011, Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells, PLoS One, 6, e21717, 10.1371/journal.pone.0021717

Gan, 2008, Tubulin-targeted drug action: functional significance of class II and class IVb beta-tubulin in vinca alkaloid sensitivity, Cancer Res, 68, 9817, 10.1158/0008-5472.CAN-08-1501

Cucchiarelli, 2008, Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas, Cell Motil Cytoskeleton, 65, 675, 10.1002/cm.20297

Don, 2004, Neuronal-associated microtubule proteins class III beta-tubulin and MAP2c in neuroblastoma: role in resistance to microtubule-targeted drugs, Mol Cancer Ther, 3, 1137, 10.1158/1535-7163.1137.3.9

Bhattacharya, 2004, A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation, Mol Biol Cell, 15, 3123, 10.1091/mbc.E04-01-0060

Lobert, 2011, Regulation of beta-tubulin isotypes by micro-RNA 100 in MCF7 breast cancer cells, Cytoskeleton (Hoboken), 68, 355, 10.1002/cm.20517

Verrills, 2003, Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations, J Biol Chem, 278, 45082, 10.1074/jbc.M303378200

Mozzetti, 2008, Molecular mechanisms of patupilone resistance, Cancer Res, 68, 10197, 10.1158/0008-5472.CAN-08-2091

Dozier, 2003, Beta class II tubulin predominates in normal and tumor breast tissues, Breast Cancer Res, 5, R157, 10.1186/bcr631

Blade, 1999, Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel, J Cell Sci, 112, 2213, 10.1242/jcs.112.13.2213

Ranganathan, 2001, Modulation of endogenous beta-tubulin isotype expression as a result of human beta(III) cDNA transfection into prostate carcinoma cells, Br J Cancer, 85, 735, 10.1054/bjoc.2001.1956

Hari, 2003, Expression of class III β-tubulin reduces microtubule assembly and confers resistance to paclitaxel, Cell Motil Cytoskeleton, 56, 45, 10.1002/cm.10132

Levallet, 2012, High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway, Mol Cancer Ther, 11, 1203, 10.1158/1535-7163.MCT-11-0899

Cochrane, 2009, MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents, Mol Cancer Ther, 8, 1055, 10.1158/1535-7163.MCT-08-1046

Leskela, 2011, The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients, Endocr Relat Cancer, 18, 85, 10.1677/ERC-10-0148

Akasaka, 2009, Loss of class III beta-tubulin induced by histone deacetylation is associated with chemosensitivity to paclitaxel in malignant melanoma cells, J Invest Dermatol, 129, 1516, 10.1038/jid.2008.406

Izutsu, 2008, Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells, Int J Oncol, 32, 1227

Tsourlakis, 2014, βIII-tubulin overexpression is an independent predictor of prostate cancer progression tightly linked to ERG fusion status and PTEN deletion, Am J Pathol, 184, 609, 10.1016/j.ajpath.2013.11.007

Ranganathan, 1998, Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents, Biochim Biophys Acta, 1395, 237, 10.1016/S0167-4781(97)00168-1

Saussede-Aim, 2009, Vinorelbine induces beta 3-tubulin gene expression through an AP-1 site, Anticancer Res, 29, 3003

Raspaglio, 2008, Hypoxia induces class III beta-tubulin gene expression by HIF-1 alpha binding to its 3’ flanking region, Gene, 409, 100, 10.1016/j.gene.2007.11.015

Raspaglio, 2010, HuR regulates beta-tubulin isotype expression in ovarian cancer, Cancer Res, 70, 5891, 10.1158/0008-5472.CAN-09-4656

Masuda, 2009, RNA-binding proteins implicated in the hypoxic response, J Cell Mol Med, 13, 2759, 10.1111/j.1582-4934.2009.00842.x

Schwarz, 1998, Beta-tubulin isotypes purified from bovine brain have different relative stabilities, Biochemistry, 37, 4687, 10.1021/bi972763d

Boekelheide, 1992, Cis-diamminedichloroplatinum (ii) (cisplatin) alters microtubule assembly dynamics, Toxicol Appl Pharmacol, 116, 146, 10.1016/0041-008X(92)90156-M

Gan, 2010, Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of beta III-tubulin, Mol Cancer Ther, 9, 1339, 10.1158/1535-7163.MCT-09-0679

Kumar, 1981, Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin, J Biol Chem, 256, 7678, 10.1016/S0021-9258(19)69014-9

Peris, 2009, Motor-dependent microtubule disassembly driven by tubulin tyrosination, J Cell Biol, 185, 1159, 10.1083/jcb.200902142

Soucek, 2006, Normal and prostate cancer cells display distinct molecular profiles of α-tubulin posttranslational modifications, Prostate, 66, 954, 10.1002/pros.20416

Mialhe, 2001, Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis, Cancer Res, 61, 5024

Lafanechere, 1998, Suppression of tubulin tyrosine ligase during tumor growth, J Cell Sci, 111, 171, 10.1242/jcs.111.2.171

Kato, 2004, Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis, Int J Cancer, 112, 365, 10.1002/ijc.20431

Whipple, 2010, Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement, Cancer Res, 70, 8127, 10.1158/0008-5472.CAN-09-4613

Giustiniani, 2009, Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53, Cell Signal, 21, 529, 10.1016/j.cellsig.2008.12.004

Zhang, 2004, HDAC6 expression is correlated with better survival in breast cancer, Clin Cancer Res, 10, 6962, 10.1158/1078-0432.CCR-04-0455

Li, 2007, Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin, J Neurosci, 27, 2606, 10.1523/JNEUROSCI.4181-06.2007

Ng, 2013, Sirtuins’ modulation of autophagy, J Cell Physiol, 228, 2262, 10.1002/jcp.24399

Tran, 2007, HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions, J Cell Sci, 120, 1469, 10.1242/jcs.03431

Gao, 2010, The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation, J Biol Chem, 285, 11219, 10.1074/jbc.M109.042754

Friedman, 2010, ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules, J Cell Biol, 190, 363, 10.1083/jcb.200911024

Daire, 2009, Kinesin-1 regulates microtubule dynamics via a c-Jun N-terminal kinase-dependent mechanism, J Biol Chem, 284, 31992, 10.1074/jbc.M109.007906

Miller, 2008, Increased levels of a unique post-translationally modified βIVb-tubulin isotype in liver cancer, Biochemistry, 47, 7572, 10.1021/bi8005225

Wasylyk, 2010, Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy, Int J Cancer, 127, 2542, 10.1002/ijc.25261

Bhat, 2007, Microtubule-associated proteins as targets in cancer chemotherapy, Clin Cancer Res, 13, 2849, 10.1158/1078-0432.CCR-06-3040

Rouzier, 2005, Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer, Proc Natl Acad Sci U S A, 102, 8315, 10.1073/pnas.0408974102

Soltani, 2005, Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma, Am J Pathol, 166, 1841, 10.1016/S0002-9440(10)62493-5

Song, 2010, Increased expression of MAP2 inhibits melanoma cell proliferation, invasion and tumor growth in vitro and in vivo, Exp Dermatol, 19, 958, 10.1111/j.1600-0625.2009.01020.x

Verrills, 2003, Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions, Chem Biol, 10, 597, 10.1016/S1074-5521(03)00141-8

Sun, 2012, Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity, J Pathol, 226, 666, 10.1002/path.3026

Byrne, 2014, RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model, Oncogene, 33, 882, 10.1038/onc.2013.11

Rath, 2012, Kinesins and cancer, Nat Rev Cancer, 12, 527, 10.1038/nrc3310

Sirajuddin, 2014, Regulation of microtubule motors by tubulin isotypes and post-translational modifications, Nat Cell Biol, 16, 335, 10.1038/ncb2920

LaPointe, 2013, Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy, Neurotoxicology, 37, 231, 10.1016/j.neuro.2013.05.008

Dhillon, 2007, MAP kinase signalling pathways in cancer, Oncogene, 26, 3279, 10.1038/sj.onc.1210421

Reszka, 1995, Association of mitogen-activated protein-kinase with the microtubule cytoskeleton, Proc Natl Acad Sci U S A, 92, 8881, 10.1073/pnas.92.19.8881

Zhou, 2002, Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine, J Biol Chem, 277, 39777, 10.1074/jbc.M203927200

Wang, 1999, Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells, J Biol Chem, 274, 8208, 10.1074/jbc.274.12.8208

Seidman, 2001, The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells, Exp Cell Res, 268, 84, 10.1006/excr.2001.5262

Geeraert, 2010, Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation, J Biol Chem, 285, 24184, 10.1074/jbc.M109.091553

Tararuk, 2006, JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length, J Cell Biol, 173, 265, 10.1083/jcb.200511055

Chang, 2003, JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins, Dev Cell, 4, 521, 10.1016/S1534-5807(03)00094-7

Fan, 2001, Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy, Drug Resist Updat, 4, 253, 10.1054/drup.2001.0214

Brantley-Finley, 2003, The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide, Biochem Pharmacol, 66, 459, 10.1016/S0006-2952(03)00255-7

Kolomeichuk, 2008, Distinct signaling pathways of microtubule inhibitors – vinblastine and taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively, FEBS J, 275, 1889, 10.1111/j.1742-4658.2008.06349.x

Hoshi, 1992, Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein-2 and microtubule-associated protein-4, induces an alteration in their function, Eur J Biochem, 203, 43, 10.1111/j.1432-1033.1992.tb19825.x

Reszka, 1997, Mitogen-activated protein kinase extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions, Mol Biol Cell, 8, 1219, 10.1091/mbc.8.7.1219

Hu, 2010, The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells, Cell Mol Life Sci, 67, 321, 10.1007/s00018-009-0187-z

Liu, 2001, Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells, Br J Cancer, 85, 1403, 10.1054/bjoc.2001.1910

Giannakakou, 2002, Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics, Proc Natl Acad Sci U S A, 99, 10855, 10.1073/pnas.132275599

Galigniana, 2004, Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus, J Biol Chem, 279, 22483, 10.1074/jbc.M402223200

Giannakakou, 2000, p53 Is associated with cellular microtubules and is transported to the nucleus by dynein, Nat Cell Biol, 2, 709, 10.1038/35036335

Peng, 2001, Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization, J Biol Chem, 276, 40583, 10.1074/jbc.M102817200

Kim, 2013, p53 Acetylation enhances taxol-induced apoptosis in human cancer cells, Apoptosis, 18, 110, 10.1007/s10495-012-0772-8

Lee, 2008, Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells, FEBS Lett, 582, 2826, 10.1016/j.febslet.2008.07.021

Galmarini, 2003, Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics, Br J Cancer, 88, 1793, 10.1038/sj.bjc.6600960

Mabjeesh, 2003, 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF, Cancer Cell, 3, 363, 10.1016/S1535-6108(03)00077-1

Obacz, 2013, Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses, Mol Cancer, 12, 93, 10.1186/1476-4598-12-93

Ivan, 2001, HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O-2 sensing, Science, 292, 464, 10.1126/science.1059817

Fang, 2011, MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1, PLoS One, 6, e28052, 10.1371/journal.pone.0028052

Yoon, 2005, Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha 6 beta 4 integrin, Cancer Res, 65, 2761, 10.1158/0008-5472.CAN-04-4122

Xu, 2013, Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia, Mol Cells, 36, 322, 10.1007/s10059-013-0114-x

Hinman, 2008, Diverse molecular functions of Hu proteins, Cell Mol Life Sci, 65, 3168, 10.1007/s00018-008-8252-6

Katsetos, 2001, Aberrant localization of the neuronal class III beta-tubulin in astrocytomas – a marker for anaplastic potential, Arch Pathol Lab Med, 125, 613, 10.5858/2001-125-0613-ALOTNC

Frew, 2013, Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics, Eur J Cancer, 49, 2433, 10.1016/j.ejca.2013.02.024

Carbonaro, 2012, Microtubules regulate hypoxia-inducible factor-1 alpha protein trafficking and activity implications for taxane therapy, J Biol Chem, 287, 11859, 10.1074/jbc.M112.345587

Carbonaro, 2011, Microtubule disruption targets HIF-1 alpha mRNA to cytoplasmic P-bodies for translational repression, J Cell Biol, 192, 83, 10.1083/jcb.201004145

Al-Mehdi, 2012, Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription, Sci Signal, 5, ra47, 10.1126/scisignal.2002712

Gorrini, 2013, Modulation of oxidative stress as an anticancer strategy, Nat Rev Drug Discov, 12, 931, 10.1038/nrd4002

Cicchillitti, 2008, Proteomic characterization of cytoskeletal and mitochondrial class III beta-tubulin, Mol Cancer Ther, 7, 2070, 10.1158/1535-7163.MCT-07-2370

Azuma, 2009, Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel, Lung Cancer, 64, 326, 10.1016/j.lungcan.2008.09.002

Joe, 2008, The roles of cys124 and ser239 in the functional properties of human beta III tubulin, Cell Motil Cytoskeleton, 65, 476, 10.1002/cm.20274

Eiserich, 1999, Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury, Proc Natl Acad Sci U S A, 96, 6365, 10.1073/pnas.96.11.6365

Bisig, 2002, Incorporation of 3-nitrotyrosine into the C-terminus of alpha-tubulin is reversible and not detrimental to dividing cells, Eur J Biochem, 269, 5037, 10.1046/j.1432-1033.2002.03220.x

Cappelletti, 2006, Protein tyrosine nitration is associated with cold- and drug-resistant microtubules in neuronal-like PC 12 cells, Neurosci Lett, 401, 159, 10.1016/j.neulet.2006.03.009

Fiore, 2006, Tubulin nitration in human gliomas, Neurosci Lett, 394, 57, 10.1016/j.neulet.2005.10.011

Kim, 2008, Reactive oxygen species-dependent EndoG release mediates cisplatin-induced caspase-independent apoptosis in human head and neck squamous carcinoma cells, Int J Cancer, 122, 672, 10.1002/ijc.23158

Selimovic, 2008, Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2, Cell Signal, 20, 311, 10.1016/j.cellsig.2007.10.015

Alexandre, 2007, Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species, Cancer Res, 67, 3512, 10.1158/0008-5472.CAN-06-3914

Putnam, 2003, External mechanical strain regulates membrane targeting of Rho GTPases by controlling microtubule assembly, Am J Physiol Cell Physiol, 284, C627, 10.1152/ajpcell.00137.2002

Cheng, 2006, Nox1-dependent reactive oxygen generation is regulated by Rac1, J Biol Chem, 281, 17718, 10.1074/jbc.M512751200

Roediger, 2003, Oxidative stress induces axonal beading in cultured human brain tissue, Neurobiol Dis, 13, 222, 10.1016/S0969-9961(03)00038-X

Valen, 1999, Hydrogen peroxide induces endothelial cell atypia and cytoskeleton depolymerization, Free Radic Biol Med, 26, 1480, 10.1016/S0891-5849(99)00009-X

Hinshaw, 1993, A cellular-model of oxidant-mediated neuronal injury, Brain Res, 615, 13, 10.1016/0006-8993(93)91110-E

Stewart, 2007, Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization, Chem Res Toxicol, 20, 1111, 10.1021/tx700106v

Neely, 2005, Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction, Brain Res, 1037, 90, 10.1016/j.brainres.2004.12.027

Kokubo, 2008, Mechanism of destruction of microtubule structures by 4-hydroxy-2-nonenal, Cell Struct Funct, 33, 51, 10.1247/csf.07038

Divinski, 2006, Peptide neuroprotection through specific interaction with brain tubulin, J Neurochem, 98, 973, 10.1111/j.1471-4159.2006.03936.x

Stamer, 2002, Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress, J Cell Biol, 156, 1051, 10.1083/jcb.200108057

Altman, 2012, Metabolic stress in autophagy and cell death pathways, Cold Spring Harb Perspect Biol, 4, a008763, 10.1101/cshperspect.a008763

Saks, 1995, Control of cellular respiration in-vivo by mitochondrial outer-membrane and by creatine-kinase – a new speculative hypothesis – possible involvement of mitochondrial-cytoskeleton interactions, J Mol Cell Cardiol, 27, 625, 10.1016/S0022-2828(08)80056-9

Bershadsky, 1981, ATP-dependent regulation of cytoplasmic microtubule disassembly, Proc Natl Acad Sci U S A, 78, 3610, 10.1073/pnas.78.6.3610

Infante, 2000, Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap, J Cell Sci, 113, 3907, 10.1242/jcs.113.22.3907

Marcussen, 1996, Cell cycle-dependent regulation of cellular ATP concentration, and depolymerization of the interphase microtubular network induced by elevated cellular ATP concentration in whole fibroblasts, Cell Motil Cytoskeleton, 35, 94, 10.1002/(SICI)1097-0169(1996)35:294::AID-CM23.0.CO;2-I

Nakano, 2010, AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation, Nat Cell Biol, 12, 583, 10.1038/ncb2060

Williams, 2011, AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress, Proc Natl Acad Sci U S A, 108, 5849, 10.1073/pnas.1013660108

Tuerk, 2007, New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases, J Proteome Res, 6, 3266, 10.1021/pr070160a

Sheldon, 2011, Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin, PLoS One, 6, e25539, 10.1371/journal.pone.0025539

Rostovtseva, 2008, Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration, Proc Natl Acad Sci U S A, 105, 18746, 10.1073/pnas.0806303105

Carre, 2002, Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel, J Biol Chem, 277, 33664, 10.1074/jbc.M203834200

Maldonado, 2013, Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin, J Biol Chem, 288, 11920, 10.1074/jbc.M112.433847

Vertessy, 1999, Pyruvate kinase as a microtubule destabilizing factor in vitro, Biochem Biophys Res Commun, 254, 430, 10.1006/bbrc.1998.9957

Orosz, 1999, Phosphofructokinase from Dictyostelium discoideum is a potent inhibitor of tubulin polymerization, Biochemistry, 38, 1857, 10.1021/bi981350p

Marmillot, 1994, Effect of tubulin on the activity of the muscle isoenzyme of lactate-dehydrogenase, Arch Biochem Biophys, 315, 467, 10.1006/abbi.1994.1526

Volker, 1997, A glycolytic enzyme binding domain on tubulin, Arch Biochem Biophys, 338, 237, 10.1006/abbi.1996.9819

Muronetz, 1994, Binding constants and stoichiometries of glyceraldehyde-3-phosphate dehydrogenase-tubulin complexes, Arch Biochem Biophys, 313, 253, 10.1006/abbi.1994.1385

Durrieu, 1987, Microtubules bind glyceraldehyde-3-phosphate dehydrogenase and modulate its enzyme-activity and quaternary structure, Arch Biochem Biophys, 252, 32, 10.1016/0003-9861(87)90005-1

Tisdale, 2004, Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity, J Biol Chem, 279, 54046, 10.1074/jbc.M409472200

Aon, 2002, Coherent and robust modulation of a metabolic network by cytoskeletal organization and dynamics, Biophys Chem, 97, 213, 10.1016/S0301-4622(02)00056-X

Zala, 2013, Vesicular glycolysis provides on-board energy for fast axonal transport, Cell, 152, 479, 10.1016/j.cell.2012.12.029

Glaser, 2002, Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: implications for the coordinated regulation of glycolysis and membrane fusion, Proc Natl Acad Sci U S A, 99, 14104, 10.1073/pnas.222542999

Tisdale, 2009, Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase c iota to associate with microtubules and to recruit dynein, J Biol Chem, 284, 5876, 10.1074/jbc.M807756200

Cueille, 2007, Microtubule-associated protein 1B binds glyceraldehyde-3-phosphate dehydrogenase, J Proteome Res, 6, 2640, 10.1021/pr070081z

Kovacs, 2003, Phosphoenolpyruvate-dependent tubulin-pyruvate kinase interaction at different organizational levels, J Biol Chem, 278, 7126, 10.1074/jbc.M210244200

Brinkley, 1974, Rotenone inhibition of spindle microtubule assembly in mammalian-cells, Exp Cell Res, 85, 41, 10.1016/0014-4827(74)90210-9

Dodson, 2013, Cellular metabolic and autophagic pathways: traffic control by redox signaling, Free Radic Biol Med, 63, 207, 10.1016/j.freeradbiomed.2013.05.014

Jin, 2007, Role of autophagy in cancer – management of metabolic stress, Autophagy, 3, 28, 10.4161/auto.3269

Xie, 2011, Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis, Cancer Res, 71, 7537, 10.1158/0008-5472.CAN-11-2170

Guo, 2013, Autophagy-mediated tumor promotion, Cell, 155, 1216, 10.1016/j.cell.2013.11.019

Sui, 2013, Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment, Cell Death Dis, 4, e838, 10.1038/cddis.2013.350

Macintosh, 2013, Autophagy in tumour cell death, Semin Cancer Biol, 23, 344, 10.1016/j.semcancer.2013.05.006

Amenta, 1977, Effect of microtubular or translational inhibitors on general cell protein degradation – evidence for a dual catabolic pathway, Biochem J, 168, 223, 10.1042/bj1680223

Fass, 2006, Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes, J Biol Chem, 281, 36303, 10.1074/jbc.M607031200

Fengsrud, 1995, Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes – effects of vinblastine and asparagine on vacuole distributions, Exp Cell Res, 221, 504, 10.1006/excr.1995.1402

Kochl, 2006, Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes, Traffic, 7, 129, 10.1111/j.1600-0854.2005.00368.x

Webb, 2004, Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases, Int J Biochem Cell Biol, 36, 2541, 10.1016/j.biocel.2004.02.003

Acharya, 2011, The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells, Apoptosis, 16, 924, 10.1007/s10495-011-0613-1

Viola, 2012, MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells, Biochem Pharmacol, 83, 16, 10.1016/j.bcp.2011.09.017

Kouno, 2005, Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains, J Biol Chem, 280, 24610, 10.1074/jbc.M413565200

Liu, 2012, MAP1S enhances autophagy to suppress tumorigenesis, Autophagy, 8, 278, 10.4161/auto.8.2.18939

Xie, 2011, Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation, J Biol Chem, 286, 10367, 10.1074/jbc.M110.206532

Di Bartolomeo, 2010, The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy, J Cell Biol, 191, 155, 10.1083/jcb.201002100

Luo, 2012, Bim inhibits autophagy by recruiting beclin 1 to microtubules, Mol Cell, 47, 359, 10.1016/j.molcel.2012.05.040

Chen, 2013, Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth, Toxicology, 310, 92, 10.1016/j.tox.2013.05.012

Sancak, 2010, Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids, Cell, 141, 290, 10.1016/j.cell.2010.02.024

Korolchuk, 2011, Lysosomal positioning coordinates cellular nutrient responses, Nat Cell Biol, 13, 453, 10.1038/ncb2204

Wei, 2008, JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy, Mol Cell, 30, 678, 10.1016/j.molcel.2008.06.001

Mochizuki, 2013, Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways, J Biol Chem, 288, 1009, 10.1074/jbc.M112.395087

Yang, 2013, Bit-by-bit autophagic removal of parkin-labelled mitochondria, Nat Commun, 4, 2428, 10.1038/ncomms3428

Appaix, 2003, Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria, Exp Physiol, 88, 175, 10.1113/eph8802511

Terasaki, 1986, Microtubules and the endoplasmic-reticulum are highly interdependent structures, J Cell Biol, 103, 1557, 10.1083/jcb.103.4.1557

Aplin, 1992, Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles, J Cell Physiol, 152, 458, 10.1002/jcp.1041520304

Reunanen, 1988, Effects of griseofulvin and nocodazole on the accumulation of autophagic vacuoles in ehrlich ascites tumor-cells, Exp Mol Pathol, 48, 97, 10.1016/0014-4800(88)90048-2

Kimura, 2008, Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes, Cell Struct Funct, 33, 109, 10.1247/csf.08005

Luo, 2013, The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies, Oncogene, 32, 805, 10.1038/onc.2012.130

Ma, 2004, The role of the unfolded protein response in tumour development: friend or foe?, Nat Rev Cancer, 4, 966, 10.1038/nrc1505

Dong, 2008, Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development, Cancer Res, 68, 498, 10.1158/0008-5472.CAN-07-2950

Reddy, 2003, Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors – role of ATP binding site in suppression of caspase-7 activation, J Biol Chem, 278, 20915, 10.1074/jbc.M212328200

Sun, 2013, Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways, Neuro Oncol, 15, 562, 10.1093/neuonc/not005

Yamada, 1999, Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress, Cancer Chemother Pharmacol, 44, 59, 10.1007/s002800050945

Chatterjee, 1997, Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78, Cancer Res, 57, 5112

Luvsandagva, 2012, GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer, Gynecol Oncol, 126, 132, 10.1016/j.ygyno.2012.04.025

Li, 2006, Stress induction of GRP78/BiP and its role in cancer, Curr Mol Med, 6, 45, 10.2174/156652406775574523

Liu, 2011, FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways, J Cell Biochem, 112, 453, 10.1002/jcb.22927

Bett, 2013, The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability, Biochem J, 451, 185, 10.1042/BJ20130026

Chernov, 2009, Role of microtubules in stress granule assembly-microtubule dynamical instability favors the formation of micrometric stress granules in cells, J Biol Chem, 284, 36569, 10.1074/jbc.M109.042879

Anderson, 2006, RNA granules, J Cell Biol, 172, 803, 10.1083/jcb.200512082

Sriburi, 2004, XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum, J Cell Biol, 167, 35, 10.1083/jcb.200406136

Schuck, 2009, Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response, J Cell Biol, 187, 525, 10.1083/jcb.200907074

Goyal, 2013, Untangling the web: mechanisms underlying ER network formation, Biochim Biophys Acta, 1833, 2492, 10.1016/j.bbamcr.2013.04.009

Waterman-Storer, 1997, Microtubule dynamics: treadmilling comes around again, Curr Biol, 7, R369, 10.1016/S0960-9822(06)00177-1

Lee, 1988, Dynamic behavior of endoplasmic-reticulum in living cells, Cell, 54, 37, 10.1016/0092-8674(88)90177-8

Ogburn, 2006, Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates, J Biol Chem, 281, 23274, 10.1074/jbc.M600635200

Wettstein, 2012, Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?, Int J Biochem Cell Biol, 44, 1680, 10.1016/j.biocel.2012.05.024

Ghosh, 2007, Interactive domains in the molecular chaperone human alpha B crystallin modulate microtubule assembly and disassembly, PLoS One, 2, e498, 10.1371/journal.pone.0000498

Houck, 2010, Dynamic subunit exchange and the regulation of microtubule assembly by the stress response protein human alpha B crystallin, PLoS One, 5, e11795, 10.1371/journal.pone.0011795

Fujita, 2004, Alpha B-crystallin-coated MAP microtubule resists nocodazole and calcium-induced disassembly, J Cell Sci, 117, 1719, 10.1242/jcs.01021

Hino, 2000, Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells, Biochem Biophys Res Commun, 271, 164, 10.1006/bbrc.2000.2553

Almeida-Souza, 2013, HSPB1 facilitates the formation of non-centrosomal microtubules, PLoS One, 8, e66541, 10.1371/journal.pone.0066541

Casado, 2007, Characterization of HSP27 phosphorylation induced by microtubule interfering agents: implication of p38 signalling pathway, Arch Biochem Biophys, 461, 123, 10.1016/j.abb.2007.01.027

Sanchez, 1994, Binding of heat-shock protein-70 (hsp70) to tubulin, Arch Biochem Biophys, 310, 428, 10.1006/abbi.1994.1188

Welch, 1985, The mammalian stress response and the cytoskeleton – alterations in intermediate filaments, Ann N Y Acad Sci, 455, 57, 10.1111/j.1749-6632.1985.tb50403.x

Selimovic, 2013, Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms, Apoptosis, 18, 980, 10.1007/s10495-013-0844-4

Guo, 2007, Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities, Cell Stress Chaperones, 12, 245, 10.1379/CSC-265.1

Quintá, 2011, Management of cytoskeleton architecture by molecular chaperones and immunophilins, Cell Signal, 23, 1907, 10.1016/j.cellsig.2011.07.023

Hong, 2013, Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions, Cancer Treat Rev, 39, 375, 10.1016/j.ctrv.2012.10.001

Weis, 2010, The 90-kDa heat Shock protein Hsp90 protects tubulin against thermal denaturation, J Biol Chem, 285, 9525, 10.1074/jbc.M109.096586

Pratt, 2003, Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery, Exp Biol Med, 228, 111, 10.1177/153537020322800201

Pratt, 2010, Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage, Exp Biol Med, 235, 278, 10.1258/ebm.2009.009250

Rovini, 2011, Microtubule-targeted agents: when mitochondria become essential to chemotherapy, Biochim Biophys Acta, 1807, 679, 10.1016/j.bbabio.2011.01.001

Ren, 2003, Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation, J Neurosci, 23, 3316, 10.1523/JNEUROSCI.23-08-03316.2003

Jung, 1993, Interaction of brain mitochondria with microtubules reconstituted from brain tubulin and MAP2 or Tau, Cell Motil Cytoskeleton, 24, 245, 10.1002/cm.970240405

Maldonado, 2010, Free tubulin modulates mitochondrial membrane potential in cancer cells, Cancer Res, 70, 10192, 10.1158/0008-5472.CAN-10-2429

Guzun, 2011, Mitochondria-cytoskeleton interaction: distribution of beta-tubulins in cardiomyocytes and HL-1 cells, Biochim Biophys Acta, 1807, 458, 10.1016/j.bbabio.2011.01.010

Andre, 2000, Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells, Cancer Res, 60, 5349

Ferlini, 2003, Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance, Mol Pharmacol, 64, 51, 10.1124/mol.64.1.51

Gajate, 2000, Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2’,3’,4’-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one: protection by bcl-2 and bcl-x(L) and cell cycle arrest, Cancer Res, 60, 2651

Ibrado, 1997, Bcl-x(L) overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells, Cancer Res, 57, 1109

Esteve, 2006, Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine, Mol Cancer Ther, 5, 2824, 10.1158/1535-7163.MCT-06-0277

Knipling, 2006, Direct interaction of Bcl-2 proteins with tubulin, Biochem Biophys Res Commun, 341, 433, 10.1016/j.bbrc.2005.12.201

Puthalakath, 1999, The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex, Mol Cell, 3, 287, 10.1016/S1097-2765(00)80456-6

Giodini, 2002, Regulation of microtubule stability and mitotic progression by survivin, Cancer Res, 62, 2462

Prislei, 2008, From plasma membrane to cytoskeleton: a novel function for semaphorin 6A, Mol Cancer Ther, 7, 233, 10.1158/1535-7163.MCT-07-0390

Srivastava, 1998, Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase, Mol Cell Biol, 18, 3509, 10.1128/MCB.18.6.3509

Ling, 1998, Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis, J Biol Chem, 273, 18984, 10.1074/jbc.273.30.18984

Verdier-Pinard, 2009, Tubulin proteomics: towards breaking the code, Anal Biochem, 384, 197, 10.1016/j.ab.2008.09.020

Hasegawa, 2003, Prediction of response to docetaxel by quantitative analysis of class I and III beta-tubulin isotype mRNA expression in human breast cancers, Clin Cancer Res, 9, 2992

Zhang, 2012, Association between class III beta-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: a meta-analysis, Lung Cancer, 77, 9, 10.1016/j.lungcan.2012.01.005

Sève, 2007, Class III β-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10, Clin Cancer Res, 13, 994, 10.1158/1078-0432.CCR-06-1503

Reiman, 2012, Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials, Ann Oncol, 23, 86, 10.1093/annonc/mdr033

Seve, 2005, Expression of class III beta-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy, Clin Cancer Res, 11, 5481, 10.1158/1078-0432.CCR-05-0285

Ohishi, 2007, Expression of beta-tubulin isotypes in human primary ovarian carcinoma, Gynecol Oncol, 105, 586, 10.1016/j.ygyno.2007.01.044

Kavallaris, 1997, Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes, J Clin Invest, 100, 1282, 10.1172/JCI119642

De Donato, 2012, Class III beta-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer, J Cell Physiol, 227, 1034, 10.1002/jcp.22813

Su, 2009, Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxel, Cancer, 115, 2453, 10.1002/cncr.24282

Aoki, 2009, Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma, Clin Cancer Res, 15, 1473, 10.1158/1078-0432.CCR-08-1274

Paradiso, 2005, Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer, Ann Oncol, 16, 14, 10.1093/annonc/mdi902

Portyanko, 2009, Beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion, Virchows Arch, 454, 541, 10.1007/s00428-009-0764-4

Roque, 2013, Tubulin-beta-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones, Cancer, 119, 2582, 10.1002/cncr.28017

Hwang, 2013, Class III beta-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer, BMC Cancer, 13, 431, 10.1186/1471-2407-13-431

Ploussard, 2010, Class III beta-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy, Cancer Res, 70, 9253, 10.1158/0008-5472.CAN-10-1447

Terry, 2009, Increased expression of class III beta-tubulin in castration-resistant human prostate cancer, Br J Cancer, 101, 951, 10.1038/sj.bjc.6605245

Bernard-Marty, 2002, Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study, Clin Breast Cancer, 3, 341, 10.3816/CBC.2002.n.037

Christoph, 2012, BetaV-tubulin expression is associated with outcome following taxane-based chemotherapy in non-small cell lung cancer, Br J Cancer, 107, 823, 10.1038/bjc.2012.324

Lu, 2013, Increased alpha-tubulin1b expression indicates poor prognosis and resistance to chemotherapy in hepatocellular carcinoma, Dig Dis Sci, 58, 2713, 10.1007/s10620-013-2692-z

Caracciolo, 2010, Differential expression and cellular distribution of gamma-tubulin and beta III-tubulin in medulloblastomas and human medulloblastoma cell lines, J Cell Physiol, 223, 519, 10.1002/jcp.22077