Microglial downregulation in a double transgenic mouse model associated with early-onset Alzheimer's disease (AD) after intraventricular implantation of alginate encapsulated Glukagon-like-peptide-1 (GLP-1) producing human mesenchymal stem-cells

Cerebrospinal Fluid Research - Tập 6 - Trang 1-2 - 2009
Kathrin Harmening1, Anna Heile1, Miles Miller2, Conrad E Johanson2, Christine Wallrapp3, Thomas Brinker1, Gerald D Silverberg2, Petra M Klinge2
1International Neuroscience Institute GmbH, Hannover, Germany
2Department of Clinical Neuroscience, Alpert Medical School at Brown University, Rhode Island Hospital, Providence, USA
3CellMed AG, Alzenau, Germany

Tài liệu tham khảo

Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH: Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003, 72: 603-612. 10.1002/jnr.10611.