Microfluidic 3D models of cancer

Gupta, 2006, Cancer metastasis: building a framework, Cell, 127, 679, 10.1016/j.cell.2006.11.001 Allinen, 2004, Molecular characterization of the tumor microenvironment in breast cancer, Cancer Cell, 6, 17, 10.1016/j.ccr.2004.06.010 Junttila, 2013, Influence of tumour micro-environment heterogeneity on therapeutic response, Nature, 501, 346, 10.1038/nature12626 Marusyk, 2010, Tumor heterogeneity: causes and consequences, Biochim. Biophys. Acta, 1805, 105 Straussman, 2012, Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature, 487, 500, 10.1038/nature11183 Longo, 2012, Tumor heterogeneity and personalized medicine, N. Engl. J. Med., 366, 956, 10.1056/NEJMe1200656 Bissell, 2001, Putting tumours in context, Nat. Rev. Cancer, 1, 46, 10.1038/35094059 Muthuswamy, 2011, 3D culture reveals a signaling network, Breast Cancer Res., 13, 103, 10.1186/bcr2800 Provenzano, 2008, Collagen density promotes mammary tumor initiation and progression, BMC Med., 6, 11, 10.1186/1741-7015-6-11 Provenzano, 2008, Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization, Biophys. J., 95, 5374, 10.1529/biophysj.108.133116 Levental, 2009, Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, 139, 891, 10.1016/j.cell.2009.10.027 Sung, 2013, Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer Models, PLoS ONE, 8, e76373, 10.1371/journal.pone.0076373 Grinnell, 2003, Fibroblast biology in three-dimensional collagen matrices, Trends Cell Biol., 13, 264, 10.1016/S0962-8924(03)00057-6 Arora, 1999, The compliance of collagen gels regulates transforming growth factor-β induction of α-smooth muscle actin in fibroblasts, Am. J. Pathol., 154, 871, 10.1016/S0002-9440(10)65334-5 Yamada, 2007, Modeling tissue morphogenesis and cancer in 3D, Cell, 130, 601, 10.1016/j.cell.2007.08.006 Debnath, 2003, Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures, Methods, 30, 256, 10.1016/S1046-2023(03)00032-X Kenny, 2007, The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression, Mol. Oncol., 1, 84, 10.1016/j.molonc.2007.02.004 Härmä, 2010, A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses, PLoS ONE, 5, e10431, 10.1371/journal.pone.0010431 Yu, 2005, Diffusion dependent cell behavior in microenvironments, Lab Chip, 5, 1089, 10.1039/b504403k Domenech, 2012, Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth, Integr. Biol., 10.1039/c1ib00104c Bauer, 2010, 3D microchannel co-culture: method and biological validation, Integr. Biol., 2, 371, 10.1039/c0ib00001a Sung, 2009, Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices, Biomaterials, 30, 4833, 10.1016/j.biomaterials.2009.05.043 Lee, 2006, Microfluidic alignment of collagen fibers for in vitro cell culture, Biomed. Microdevices, 8, 35, 10.1007/s10544-006-6380-z Montanez-Sauri, 2013, Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells, Integr. Biol., 5, 631, 10.1039/c3ib20225a Su, 2012, Functional screen of paracrine signals in breast carcinoma fibroblasts, PLoS ONE, 7, e46685, 10.1371/journal.pone.0046685 Derda, 2009, Paper-supported 3D cell culture for tissue-based bioassays, Proc. Natl. Acad. Sci., 106, 18457, 10.1073/pnas.0910666106 Fischbach, 2009, Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement, Proc. Natl. Acad. Sci. U. S. A., 106, 399, 10.1073/pnas.0808932106 Liu, 2007, Functional three-dimensional HepG2 aggregate cultures generated from an ultrasound trap: comparison with HepG2 spheroids, J. Cell. Biochem., 102, 1180, 10.1002/jcb.21345 Kunz-Schughart, 2004, The use of 3-D cultures for high-throughput screening: the multicellular spheroid model, 9, 273 Choi, 2010, Controlled-size embryoid body formation in concave microwell arrays, Biomaterials, 31, 4296, 10.1016/j.biomaterials.2010.01.115 Torisawa, 2007, A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip, Biomaterials, 28, 559, 10.1016/j.biomaterials.2006.08.054 Fukuda, 2006, Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures, Biomaterials, 27, 5259, 10.1016/j.biomaterials.2006.05.044 Markovitz-Bishitz, 2010, A polymer microstructure array for the formation, culturing, and high throughput drug screening of breast cancer spheroids, Biomaterials, 31, 8436, 10.1016/j.biomaterials.2010.07.050 Yeon, 2013, Application of concave microwells to pancreatic tumor spheroids enabling anticancer drug evaluation in a clinically relevant drug resistance model, PLoS ONE, 8, e73345, 10.1371/journal.pone.0073345 Wu, 2008, Microfluidic self-assembly of tumor spheroids for anticancer drug discovery, Biomed. Microdevices, 10, 197, 10.1007/s10544-007-9125-8 Tung, 2011, High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array, Analyst, 136, 473, 10.1039/C0AN00609B Hsiao, 2012, 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids, Biotechnol. Bioeng., 109, 1293, 10.1002/bit.24399 Truong, 2012, Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens, Biomaterials, 33, 181, 10.1016/j.biomaterials.2011.09.049 Wong, 2008, Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments, Biomaterials, 29, 1853, 10.1016/j.biomaterials.2007.12.044 Sung, 2011, Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects, Integr. Biol., 3, 439, 10.1039/C0IB00063A Zervantonakis, 2012, Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function, Proc. Natl. Acad. Sci. U. S. A., 109, 13515, 10.1073/pnas.1210182109 Kaji, 2010, Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions, Biochim. Biophys. Acta Huang, 2009, Engineering microscale cellular niches for three-dimensional multicellular co-cultures, Lab Chip, 9, 1740, 10.1039/b818401a Amadi, 2010, A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment, Biomed. Microdevices, 12, 1027, 10.1007/s10544-010-9457-7 Berthier, 2010, An arrayed high-content chemotaxis assay for patient diagnosis, Integr. Biol. (Camb), 2, 630, 10.1039/c0ib00030b Du, 2010, Convection-driven generation of long-range material gradients, Biomaterials, 31, 2686, 10.1016/j.biomaterials.2009.12.012 Lo, 2000, Cell movement is guided by the rigidity of the substrate, Biophys. J., 79, 144, 10.1016/S0006-3495(00)76279-5 Kass, 2007, Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis, Int. J. Biochem. Cell Biol., 39, 1987, 10.1016/j.biocel.2007.06.025 Jeon, 2000, Generation of solution and surface gradients using microfluidic systems, Langmuir, 16, 8311, 10.1021/la000600b Kim, 2010, Biological applications of microfluidic gradient devices, Integr. Biol. (Camb), 2, 584, 10.1039/c0ib00055h Provenzano, 2011, Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling, J. Cell Sci., 124, 1195, 10.1242/jcs.067009 Bayan, 2009, Fully automated, quantitative, noninvasive assessment of collagen fiber content and organization in thick collagen gels, J. Appl. Phys., 105, 102042, 10.1063/1.3116626 Legant, 2012, Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis, Integr. Biol., 4, 1164, 10.1039/c2ib20059g Legant, 2010, Measurement of mechanical tractions exerted by cells in three-dimensional matrices, Nat. Methods, 7, 969, 10.1038/nmeth.1531 Nelson, 2006, Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures, Science, 314, 298, 10.1126/science.1131000 Miller, 2012, Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues, Nat. Mater., 11, 768, 10.1038/nmat3357 Zheng, 2012, In vitro microvessels for the study of angiogenesis and thrombosis, Proc. Natl. Acad. Sci., 109, 9342, 10.1073/pnas.1201240109 Bischel, 2012, A practical method for patterning lumens through ECM hydrogels via viscous finger patterning, J. Lab. Autom., 17, 96, 10.1177/2211068211426694 Bischel, 2013, Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels, Biomaterials, 34, 1471, 10.1016/j.biomaterials.2012.11.005 Garcia-Cardeña, 2001, Biomechanical activation of vascular endothelium as a determinant of its functional phenotype, Proc. Natl. Acad. Sci. U. S. A., 98, 4478, 10.1073/pnas.071052598 Price, 2010, Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels, Biomaterials, 31, 6182, 10.1016/j.biomaterials.2010.04.041 Lin, 2000, Molecular mechanism of endothelial growth arrest by laminar shear stress, Proc. Natl. Acad. Sci. U. S. A., 97, 9385, 10.1073/pnas.170282597 Ito, 2007, Effects of frequency of pulsatile flow on morphology and integrin expression of vascular endothelial cells, Technol. Health Care, 15, 91, 10.3233/THC-2007-15203 Blackman, 2002, A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms, J. Biomech. Eng., 124, 397, 10.1115/1.1486468 Song, 2011, Fluid forces control endothelial sprouting, Proc. Natl. Acad. Sci., 108, 15342, 10.1073/pnas.1105316108 Shieh, 2011, Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts, Cancer Res., 71, 790, 10.1158/0008-5472.CAN-10-1513 Haessler, 2012, Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber, Integr. Biol., 4, 401, 10.1039/C1IB00128K Bellan, 2009, Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures, Soft Matter, 5, 1354, 10.1039/b819905a Huang, 2009, Rapid fabrication of bio-inspired 3D microfluidic vascular networks, Adv. Mater., 21, 3567, 10.1002/adma.200900584 Carugo, 2012, A microfluidic device for the characterisation of embolisation with polyvinyl alcohol beads through biomimetic bifurcations, Biomed. Microdevices, 14, 153, 10.1007/s10544-011-9593-8 Borenstein, 2009, Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate, Biomed. Microdevices, 12, 71, 10.1007/s10544-009-9361-1 Prabhakarpandian, 2008, Synthetic microvascular networks for quantitative analysis of particle adhesion, Biomed. Microdevices, 10, 585, 10.1007/s10544-008-9170-y Huh, 2012, Microengineered physiological biomimicry: organs-on-chips, Lab Chip, 12, 2156, 10.1039/c2lc40089h Huh, 2010, Reconstituting organ-level lung functions on a chip, Science, 328, 1662, 10.1126/science.1188302 Kim, 2012, Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow, Lab Chip, 12, 2165, 10.1039/c2lc40074j Sung, 2011, Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model, Lab Chip, 11, 389, 10.1039/C0LC00273A Grosberg, 2011, Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip, Lab Chip, 11, 4165, 10.1039/c1lc20557a Grafton, 2011, Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics, Integr. Biol., 3, 451, 10.1039/c0ib00132e Jang, 2010, A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells, Lab Chip, 10, 36, 10.1039/B907515A Domansky, 2010, Perfused multiwell plate for 3D liver tissue engineering, Lab Chip, 10, 51, 10.1039/B913221J Huang, 2012, Brain slice on a chip: opportunities and challenges of applying microfluidic technology to intact tissues, Lab Chip, 12, 2103, 10.1039/c2lc21142d Shuler, 2010, Body-on-a chip: using microfluidic systems to predict human responses to drugs, Pure Appl. Chem., 82, 1635, 10.1351/PAC-CON-09-10-44 Sung, 2009, A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs, Lab Chip, 9, 1385, 10.1039/b901377f DiMasi, 2010, Trends in risks associated with new drug development: success rates for investigational drugs, Clin. Pharmacol. Ther., 87, 272, 10.1038/clpt.2009.295 Kola, 2004, Opinion: can the pharmaceutical industry reduce attrition rates?, Nat. Rev. Drug Discov., 3, 711, 10.1038/nrd1470 Cucullo, 2007, Development of a humanized in vitro blood? Brain barrier model to screen for brain penetration of antiepileptic drugs, Epilepsia, 48, 505, 10.1111/j.1528-1167.2006.00960.x Sharma, 2010, Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents, Nat. Rev. Cancer, 10, 241, 10.1038/nrc2820 Kamb, 2006, Why is cancer drug discovery so difficult?, Nat. Rev. Drug Discov., 6, 115, 10.1038/nrd2155 2013, 1 Loessner, 2010, Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells, Biomaterials, 31, 8494, 10.1016/j.biomaterials.2010.07.064 Loessner, 2013, A bioengineered 3D ovarian cancer model for the assessment of peptidase–mediated enhancement of spheroid growth and intraperitoneal spread, Biomaterials, 34, 7389, 10.1016/j.biomaterials.2013.06.009 Fujimoto, 2003, Optical coherence tomography for ultrahigh resolution in vivo imaging, Nat. Biotechnol., 21, 1361, 10.1038/nbt892 Fujimoto, 2000, Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy, Neoplasia, 2, 9, 10.1038/sj.neo.7900071 Klein, 2013, Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening, Methods Pehlke, 2014 Khademhosseini, 2006, Microscale technologies for tissue engineering and biology, Proc. Natl. Acad. Sci., 103, 2480, 10.1073/pnas.0507681102 Richardson, 2001, Polymeric system for dual growth factor delivery, Nat. Biotechnol., 19, 1029, 10.1038/nbt1101-1029 Cornelia Wiegand, 2013, A superabsorbent polymer-containing wound dressing efficiently sequesters MMPs and inhibits collagenase activity in vitro, J. Mater. Sci. Mater. Med., 24, 2473, 10.1007/s10856-013-4990-6 Schwartz, 2013, A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype, PLoS ONE, 8, e81689, 10.1371/journal.pone.0081689 Joyce, 2008, Microenvironmental regulation of metastasis, Nat. Rev. Cancer, 9, 239, 10.1038/nrc2618 Zaari, 2004, Photopolymerization in microfluidic gradient generators: microscale control of substrate compliance to manipulate cell response, Adv. Mater. Weinheim., 16, 2133, 10.1002/adma.200400883 Nguyen, 2013, Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro, Proc. Natl. Acad. Sci., 110, 6712, 10.1073/pnas.1221526110 Ghajar, 2010, Tumor engineering: the other face of tissue engineering, Tissue Eng Pt A, 16, 2153, 10.1089/ten.tea.2010.0135