Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century

Andersen, 2008, Toxicology testing in the 21st century: bringing the vision to life, Toxicol Sci, 107, 324, 10.1093/toxsci/kfn255

Anderson, 2002, Anticonvulsant drugs, 231

Arnold, 2005, Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity, J Physiol, 564, 3, 10.1113/jphysiol.2004.077446

Baruchi, 2004, Functional holography of recorded neuronal networks activity, Neuroinformatics, 2, 333, 10.1385/NI:2:3:333

Bettencourt, 2008, Identification of functional information subgraphs in complex networks, Phys Rev Lett, 100, 238701, 10.1103/PhysRevLett.100.238701

Breier, 2008, Development of a high throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells, Toxicol Sci, 105, 119, 10.1093/toxsci/kfn115

Breier, 2010, Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science, Neurotoxicol Teratol, 32, 4, 10.1016/j.ntt.2009.06.005

Brown, 2004, Phasic bursts in rat magnocellular neurosecretory cells are not intrinsically regenerative in vivo, Eur J Neurosci, 19, 2977, 10.1111/j.0953-816X.2004.03408.x

Chiappalone, 2003, Networks of neurons coupled to microelectrode arrays: a neuronal sensory system for pharmacological applications, Biosens Bioelectron, 18, 627, 10.1016/S0956-5663(03)00041-1

Chiappalone, 2006, Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development, Brain Res, 1093, 41, 10.1016/j.brainres.2006.03.049

Chiappalone, 2008, Network plasticity in cortical assemblies, Eur J Neurosci, 28, 221, 10.1111/j.1460-9568.2008.06259.x

Coecke, 2007, Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies, Environ Health Perspect, 115, 924, 10.1289/ehp.9427

Collins, 2008, Transforming environmental health protection, Science, 319, 906, 10.1126/science.1154619

Costa, 2008, Neurotoxicity of pesticides: a brief review, Front Biosci, 13, 1240, 10.2741/2758

Dale, 2007, Population patch clamp electrophysiology: a breakthrough technology for ion channel screening, Mol Biosyst, 3, 714, 10.1039/b706152h

Gopal, 2003, Neurotoxic effects of mercury on auditory cortex networks growing on microelectrode arrays: a preliminary analysis, Neurotoxicol Teratol, 25, 69, 10.1016/S0892-0362(02)00321-5

Gopal, 2004, Unique responses of auditory cortex networks in vitro to low concentration of quinine, Hear Res, 192, 10, 10.1016/j.heares.2004.01.016

Gopal, 2007, Acute and sub-chronic functional neurotoxicity of methylphenidate on neural networks in vitro, J Neural Transm, 114, 1365, 10.1007/s00702-007-0759-8

Gramowski, 2000, Quantification of acute neurotoxic effects of trimethyltin using neuronal networks cultures on microelectrode arrays, Neurotoxicology, 21, 331

Gramowski, 2004, Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays, Eur J Neurosci, 19, 2815, 10.1111/j.0953-816X.2004.03373.x

Gramowski, 2006, Functional screening of traditional antidepressants with primary cortical networks grown on multielectrode neurochips, Eur J Neurosci, 24, 455, 10.1111/j.1460-9568.2006.04892.x

Gramowski, 2006, Detecting neurotoxicity through electrical activity changes of neuronal networks on multielectrode neurochips, ALTEX, 23, 410

Gritti, 2000, Excitable properties in astrocytes derived from human embryonic CNS stem cells, Eur J Neurosci, 12, 3549, 10.1046/j.1460-9568.2000.00234.x

Gross, 2006, Emerging histiotypic properties of cultured neuronal networks, 193

Gross, 2007, Neuronal network biosensors, 177

Gross, 1993, Stimulation of monolayer networks in culture through thin film indium-tin oxide recording electrodes, J Neurosci Methods, 50, 131, 10.1016/0165-0270(93)90001-8

Gross, 1995, The use of neuronal networks on multielectrode arrays as biosensors, Biosens Bioelectron, 10, 553, 10.1016/0956-5663(95)96931-N

Gross, 1997, Odor, drug and toxin analysis with neuronal networks in vitro: extracellular array recording of network responses, Biosens Bioelectron, 12, 373, 10.1016/S0956-5663(97)00012-2

Guyon, 2003, An introduction to variable and feature selection, J Mach Learn Res, 3, 1157

Ham, 2008, Spontaneous coordinated activity in cultured networks: analysis of multiple ignition sites, primary circuits, and burst phase delay distributions, J Comput Neurosci, 24, 346, 10.1007/s10827-007-0059-1

Harsch, 1998, Effects of alpha-pompilidotoxin on synchronized firing in networks of rat cortical neurons, Neuroscience, 252, 49

Heikkilä, 2009, Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro, Exp Neurol, 218, 109, 10.1016/j.expneurol.2009.04.011

Hill, 2008, Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing, Toxicology, 249, 243, 10.1016/j.tox.2008.05.014

Hofmann, 2006, Long term recordings with microelectrode arrays: studies of transcription-dependent neuronal plasticity and axonal regeneration, J Physiol Paris, 99, 125, 10.1016/j.jphysparis.2005.12.005

Hogberg, 2009, Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides, Toxicol Appl Pharmacol, 235, 268, 10.1016/j.taap.2008.12.014

Illes, 2007, Development and pharmacological modulation of embryonic stem cell-derived neuronal network activity, Exp Neurol, 207, 171, 10.1016/j.expneurol.2007.05.020

John, 2007, Novel 382-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels, J Biomol Screen, 12, 50, 10.1177/1087057106294920

Jones, 2008, The effects of environmental neurotoxicants on the dopaminergic system: a possible role in drug addiction, Biochem Pharmacol, 76, 569, 10.1016/j.bcp.2008.05.010

Keefer, 2001, NMDA receptor-dependent periodic oscillations in cultured spinal cord networks, J Neurophysiol, 86, 3030, 10.1152/jn.2001.86.6.3030

Keefer, 2001, Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors, Biosens Bioelectron, 7–8, 513, 10.1016/S0956-5663(01)00165-8

Kim, 2009, Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation, Toxicol Appl Pharmacol, 237, 168, 10.1016/j.taap.2009.03.002

Kulagina, 2006, Azaspiracid-1 inhibits bioelectrical activity of spinal cord neuronal networks, Toxicon, 47, 766, 10.1016/j.toxicon.2006.02.011

Le Pioufle, 2008, Lipid bilayer microarray for parallel recording of transmembrane in ion currents, Anal Chem, 80, 328, 10.1021/ac7016635

Lein, 2007, Meeting report alternatives for developmental neurotoxicity testing, Environ Health Perspect, 115, 764, 10.1289/ehp.9841

Losa, 2009, Relative potencies of type I and type II pyrethroids for inhibition of spontaneous firing in neuronal networks. Abstract # 2126. The Toxicologist CD, Soc Toxicol, 108

Martinoia, 2005, In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications, Biosens Bioelectron, 20, 2071, 10.1016/j.bios.2004.09.012

Meyer, 2008, Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture, Neurotoxicology, 29, 213, 10.1016/j.neuro.2007.11.005

Morefield, 2000, Drug evaluations using neuronal networks cultured on microelectrode arrays, Biosens Bioelectron, 15, 383, 10.1016/S0956-5663(00)00095-6

Natarajan, 2006, Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity, Toxicol In Vitro, 3, 375, 10.1016/j.tiv.2005.08.014

NRC, 2007

OECD. Test guideline 426. OECD guideline for testing of chemicals. Developmental neurotoxicity study. Paris. Organisation for Economic Co-operation and Development, http://www.oecdbookshop.org/oecd/display.asp?lang=en&sf1=DI&st1=5L4FG25MNKXS; 2007 [accessed 19.02.09].

Parviz, 2007, Quantification of zinc toxicity using neuronal networks on microelectrode arrays, Neurotoxicology, 28, 10.1016/j.neuro.2006.11.006

Pehl, 2004, Automated higher throughput composed screening on ion channel targets based on the Xenopus laevis oocyte expression system, Assay Drug Dev Technol, 2, 515, 10.1089/adt.2004.2.515

Philbert, 2000, Mechanisms of injury in the central nervous system, Toxicol Pathol, 28, 43, 10.1177/019262330002800107

Pizzi, 2007, Learning in human neural networks on microelectrode arrays, Biosystems, 88, 1, 10.1016/j.biosystems.2006.03.012

Pizzi, 2009, A cultured human neural network operates a robotic actuator, Biosystems, 25, 137, 10.1016/j.biosystems.2008.09.006

Potter, 2001, Distributed processing in cultured neuronal networks, Prog Brain Res, 130, 49, 10.1016/S0079-6123(01)30005-5

Radio, 2008, Developmental neurotoxicology testing in vitro: models for assessing chemical effects on neurite outgrowth, Neurotoxicity, 29, 361, 10.1016/j.neuro.2008.02.011

Radio, 2008, Assessment of chemical effects of neurite outgrowth in PC12 cells using high content screening, Toxicol Sci, 105, 106, 10.1093/toxsci/kfn114

Ravula, 2007, Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration, Neurosci Lett, 415, 34, 10.1016/j.neulet.2007.01.009

Riedmiller, 1993, A direct adaptive method for faster backpropagation learning: the Rprop algorithm, 586

Rijal-Oli, 2008, Determination of dissociation constants using spontaneous neuronal network activity recorded with microelectrode arrays in vitro, J Neurosci Methods, 173, 183, 10.1016/j.jneumeth.2008.05.025

Schroeder, 2008, Spike train data analysis of substance-specific network activity: application to functional screening in preclinical development

Selinger, 2004, Measuring synchronization in neuronal networks for biosensor applications, Biosens Bioelectron, 19, 675, 10.1016/S0956-5663(03)00267-7

Shafer, 1995, Methods for analysis of effects of neurotoxicants on synaptic transmission, 157

Shafer, 2008, Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin, Neurotoxicology, 2, 203, 10.1016/j.neuro.2008.01.002

Shimono, 2002, Chronic multichannel recordings from organtypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by non-competitive NMDA antagonists, J Neurosci Methods, 120, 193, 10.1016/S0165-0270(02)00202-9

Steidl, 2006, The rat hippocampal slice revisited with multi-electrode arrays, Brain Res, 1096, 70, 10.1016/j.brainres.2006.04.034

Streit, 1993, Regular oscillations of synaptic activity in spinal networks in vitro, J Neurophysiol, 70, 871, 10.1152/jn.1993.70.3.871

U.S. EPA. Toxicological Review of Carbon disulfide (CAS No. 75-15-0) in support of Summary Information on the Integrated Risk Information System (IRIS); 1995. http://www.epa.gov/ncea/iris/subst/0217.htm.

U.S. EPA. Health effects guidelines OPPTS 870.6300 Developmental neurotoxicity study EPA 712-C-98-239; 1998. Available at: http://www.epa.gov/opptsfrs/publications/OPPTS_Harmonized/870_Health_Effects_Test_Guidelines/Series/870-6300.pdf.

U.S. EPA Toxicological Review of Toluene (CAS No. 108-88-3) in support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-05/004. Washington, DC; September, 2005.

Vajda, 2008, Low-frequency stimulation induces stable transitions in stereotypical activity in cortical networks, Biophys J, 94, 5028, 10.1529/biophysj.107.112730

van Vliet, 2007, Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects, Neurotoxicology, 28, 1136, 10.1016/j.neuro.2007.06.004

Varghese, 2010, A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology, PLoS One, 5, 10.1371/journal.pone.0008643

Wagenaar, 2006, Persistent dynamic attractors in activity patterns of cultured neuronal networks, Phys Rev E Stat Nonlin Soft Matter Phys, 73

Wagenaar, 2006, An extremely rich repertoire of bursting patterns during the development of cortical cultures, BMC Neurosci, 7, 11, 10.1186/1471-2202-7-11

Wolansky, 2006, Relative potencies for acute effects of pyrethroids on motor function in rats, Toxicol Sci, 89, 271, 10.1093/toxsci/kfj020

Xia, 2003, Histiotypic electrophysiological responses of cultured neuronal networks to ethanol, Alcohol, 30, 167, 10.1016/S0741-8329(03)00135-6

Xia, 2003, Differential acute effects of fluoxetine on frontal and auditory cortex networks in vitro, Brain Res, 973, 151, 10.1016/S0006-8993(03)02367-9