Microbes and Oxytocin

International Review of Neurobiology - Tập 131 - Trang 91-126 - 2016
S.E. Erdman1,2, T. Poutahidis1,2
1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, United States
2Aristotle University of Thessaloniki, Thessaloniki, Greece

Tài liệu tham khảo

Ahl, 2016, Lactobacillus reuteri increases mucus thickness and ameliorates DSS-induced colitis in mice, Acta Physiologica (Oxford, England), 217, 300, 10.1111/apha.12695 Al-Amran, 2013, Oxytocin ameliorates the immediate myocardial injury in rat heart transplant through downregulation of neutrophil-dependent myocardial apoptosis, Transplantation Proceedings, 45, 2506, 10.1016/j.transproceed.2013.03.022 Albenberg, 2014, Diet and the intestinal microbiome: Associations, functions, and implications for health and disease, Gastroenterology, 146, 1564, 10.1053/j.gastro.2014.01.058 Altirriba, 2014, Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes, Endocrinology, 155, 4189, 10.1210/en.2014-1466 Amico, 2004, Anxiety and stress responses in female oxytocin deficient mice, Journal of Neuroendocrinology, 16, 319, 10.1111/j.0953-8194.2004.01161.x Arletti, 1990, Oxytocin inhibits food and fluid intake in rats, Physiology & Behavior, 48, 825, 10.1016/0031-9384(90)90234-U Balzola, 2010, Combined administration of secretin and oxytocin inhibits chronic colitis and associated activation of forebrain neurons: Commentary, Inflammatory Bowel Disease Monitoring, 22 Barengolts, 2016, Oxytocin—An emerging treatment for obesity and dysglycemia: Review of randomized controlled trials and cohort studies, Endocrine Practice, 22, 885, 10.4158/EP151192.RA Baribeau, 2015, Oxytocin and vasopressin: Linking pituitary neuropeptides and their receptors to social neurocircuits, Frontiers in Neuroscience, 9, 335, 10.3389/fnins.2015.00335 Belkaid, 2014, Role of the microbiota in immunity and inflammation, Cell, 157, 121, 10.1016/j.cell.2014.03.011 Beranger, 2014, Oxytocin reverses ovariectomy-induced osteopenia and body fat gain, Endocrinology, 155, 1340, 10.1210/en.2013-1688 Biyikli, 2006, Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism, Peptides, 27, 2249, 10.1016/j.peptides.2006.03.029 Blevins, 2015, Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans, Physiology & Behavior, 152, 438, 10.1016/j.physbeh.2015.05.023 Blevins, 2003, Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin, Brain Research, 993, 30, 10.1016/j.brainres.2003.08.036 Blevins, 2015, Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 308, R431, 10.1152/ajpregu.00441.2014 Blevins, 2013, Role of oxytocin signaling in the regulation of body weight, Reviews in Endocrine & Metabolic Disorders, 14, 311, 10.1007/s11154-013-9260-x Blevins, 2016, Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 310, R640, 10.1152/ajpregu.00220.2015 Boulange, 2016, Impact of the gut microbiota on inflammation, obesity, and metabolic disease, Genome Medicine, 8, 42, 10.1186/s13073-016-0303-2 Bravo, 2011, Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve, Proceedings of the National Academy of Sciences of the United States of America, 108, 16050, 10.1073/pnas.1102999108 Britton, 2014, Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model, Journal of Cellular Physiology, 229, 1822, 10.1002/jcp.24636 Buffington, 2016, Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring, Cell, 165, 1762, 10.1016/j.cell.2016.06.001 Bull, 2014, Part 1: The human gut microbiome in health and disease, Integrative Medicine (Encinitas), 13, 17 Bull, 2015, Part 2: Treatments for chronic gastrointestinal disease and gut dysbiosis, Integrative Medicine (Encinitas), 14, 25 Camerino, 2009, Low sympathetic tone and obese phenotype in oxytocin-deficient mice, Obesity (Silver Spring), 17, 980, 10.1038/oby.2009.12 Carter, 2014, Oxytocin pathways and the evolution of human behavior, Annual Review of Psychology, 65, 17, 10.1146/annurev-psych-010213-115110 Chang, 2016, Dysbiosis in gastrointestinal disorders, Best Practice and Research in Clinical Gastroenterology, 30, 3, 10.1016/j.bpg.2016.02.001 Chassaing, 2015, Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519, 92, 10.1038/nature14232 Chung, 2016, Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity, FEBS Open Bio, 6, 64, 10.1002/2211-5463.12024 Clemente, 2012, The impact of the gut microbiota on human health: An integrative view, Cell, 148, 1258, 10.1016/j.cell.2012.01.035 Clodi, 2008, Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men, American Journal of Physiology. Endocrinology and Metabolism, 295, E686, 10.1152/ajpendo.90263.2008 Colaianni, 2015, The “love hormone” oxytocin regulates the loss and gain of the fat-bone relationship, Frontiers in Endocrinology (Lausanne), 6, 79 Collado, 2012, Microbial ecology and host-microbiota interactions during early life stages, Gut Microbes, 3, 352, 10.4161/gmic.21215 Collins, 2016, Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting, PloS One, 11, e0153180, 10.1371/journal.pone.0153180 Conlon, 2015, The impact of diet and lifestyle on gut microbiota and human health, Nutrients, 7, 17, 10.3390/nu7010017 Costa, 2014, Neurohypophyseal hormones: Novel actors of striated muscle development and homeostasis, European Journal of Translational Myology, 24, 3790, 10.4081/bam.2014.3.217 Cotillard, 2013, Dietary intervention impact on gut microbial gene richness, Nature, 500, 585, 10.1038/nature12480 Cryan, 2012, Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour, Nature Reviews. Neuroscience, 13, 701, 10.1038/nrn3346 Deblon, 2011, Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats, PloS One, 6, e25565, 10.1371/journal.pone.0025565 Dept. of Reproductive Health and Research, W., 2012 Dethlefsen, 2007, An ecological and evolutionary perspective on human-microbe mutualism and disease, Nature, 449, 811, 10.1038/nature06245 Dinan, 2013, Psychobiotics: A novel class of psychotropic, Biological Psychiatry, 74, 720, 10.1016/j.biopsych.2013.05.001 Donaldson, 2008, Oxytocin, vasopressin, and the neurogenetics of sociality, Science, 322, 900, 10.1126/science.1158668 Douglas, 2007, Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin, Physiology & Behavior, 91, 352, 10.1016/j.physbeh.2007.04.012 Drissi, 2016, Metabolic role of lactobacilli in weight modification in humans and animals, Microbial Pathogenesis, 10.1016/j.micpath.2016.03.006 Ducatelle, 2015, A review on prebiotics and probiotics for the control of dysbiosis: Present status and future perspectives, Animal, 9, 43, 10.1017/S1751731114002584 Eaton, 2011, Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree mice, Infection and Immunity, 79, 185, 10.1128/IAI.00880-10 Elabd, 2008, Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis, Stem Cells, 26, 2399, 10.1634/stemcells.2008-0127 Elabd, 2014, Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration, Nature Communications, 5, 4082, 10.1038/ncomms5082 Elands, 1990, Neurohypophyseal hormone receptors in the rat thymus, spleen, and lymphocytes, Endocrinology, 126, 2703, 10.1210/endo-126-5-2703 Eming, 2014, Wound repair and regeneration: Mechanisms, signaling, and translation, Science Translational Medicine, 6, 265sr6, 10.1126/scitranslmed.3009337 Erdman, 2010, Cancer inflammation and regulatory T cells, International Journal of Cancer, 127, 768 Erdman, 2014, The microbiome modulates the tumor macroenvironment, Oncoimmunology, 3, e28271, 10.4161/onci.28271 Erdman, 2014, Probiotic ‘glow of health’: It's more than skin deep, Beneficial Microbes, 5, 109, 10.3920/BM2013.0042 Erdman, 2015, Gut bacteria and cancer, Biochimica et Biophysica Acta, 1856, 86 Erkanli Senturk, 2013, The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder, Peptides, 40, 82, 10.1016/j.peptides.2012.12.006 Fabia, 1993, The effect of exogenous administration of Lactobacillus reuteri R2LC and oat fiber on acetic acid-induced colitis in the rat, Scandinavian Journal of Gastroenterology, 28, 155, 10.3109/00365529309096063 Fak, 2012, Lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in Apoe−/− Mice, PloS One, 7, e46837, 10.1371/journal.pone.0046837 Farshim, 2016, Maternal weaning modulates emotional behavior and regulates the gut-brain axis, Scientific Reports, 6, 21958, 10.1038/srep21958 Feldman, 2016, Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology, Biological Psychiatry, 79, 174, 10.1016/j.biopsych.2015.08.008 Floch, 2015, Recommendations for probiotic use—2015 update: Proceedings and consensus opinion, Journal of Clinical Gastroenterology, 49, S69, 10.1097/MCG.0000000000000420 Foster, 2013, Gut-brain axis: How the microbiome influences anxiety and depression, Trends in Neurosciences, 36, 305, 10.1016/j.tins.2013.01.005 Fujimura, 2010, Role of the gut microbiota in defining human health, Expert Review of Anti-Infective Therapy, 8, 435, 10.1586/eri.10.14 Galley, 2014, Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota, BMC Microbiology, 14, 189, 10.1186/1471-2180-14-189 Gao, 2015, Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri, MBio, 6, e01358-15, 10.1128/mBio.01358-15 Gavrilenko, 2003, Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin, Morfologiia, 124, 24 Gimpl, 2001, The oxytocin receptor system: Structure, function, and regulation, Physiological Reviews, 81, 629, 10.1152/physrev.2001.81.2.629 Gouin, 2010, Marital behavior, oxytocin, vasopressin, and wound healing, Psychoneuroendocrinology, 35, 1082, 10.1016/j.psyneuen.2010.01.009 Gregor, 2011, Inflammatory mechanisms in obesity, Annual Review of Immunology, 29, 415, 10.1146/annurev-immunol-031210-101322 Gueniche, 2010, Bifidobacterium longum lysate, a new ingredient for reactive skin, Experimental Dermatology, 16, 511 Gurtner, 2008, Wound repair and regeneration, Nature, 453, 314, 10.1038/nature07039 Hamasaki, 2016, Neuropeptides in the brain defense against distant organ damage, Journal of Neuroimmunology, 290, 33, 10.1016/j.jneuroim.2015.11.014 Hansenne, 2009, Aire and Foxp3 expression in a particular microenvironment for T cell differentiation, Neuroimmunomodulation, 16, 35, 10.1159/000179665 Hansenne, 2005, Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network, Journal of Neuroimmunology, 158, 67, 10.1016/j.jneuroim.2004.08.007 Hildebrandt, 2009, High-fat diet determines the composition of the murine gut microbiome independently of obesity, Gastroenterology, 137, 10.1053/j.gastro.2009.08.042 Ho, 2013, Coming full circle: Contributions of central and peripheral oxytocin actions to energy balance, Endocrinology, 154, 589, 10.1210/en.2012-1751 Ho, 2015, Systemic effects of gut microbiota and its relationship with disease and modulation, BMC Immunology, 16, 21, 10.1186/s12865-015-0083-2 Hou, 2015, Study and use of the probiotic Lactobacillus reuteri in pigs: A review, Journal of Animal Science and Biotechnology, 6, 14, 10.1186/s40104-015-0014-3 Houshmand, 2009, Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats, Peptides, 30, 2301, 10.1016/j.peptides.2009.09.010 Hsieh, 2016, Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats, Food & Function, 7, 2374, 10.1039/C5FO01396H Huang, 2015, Hypolipidemic effects and safety of Lactobacillus reuteri 263 in a hamster model of hyperlipidemia, Nutrients, 7, 3767, 10.3390/nu7053767 Huseini, 2012, Evaluation of wound healing activities of kefir products, Burns, 38, 719, 10.1016/j.burns.2011.12.005 Ibrahim, 2014, Maternal gut microbes control offspring sex and survival, Journal of Probiotics and Health, 2, 6 Iseri, 2010, Oxytocin or social housing alleviates local burn injury in rats, Journal of Surgical Research, 162, 122, 10.1016/j.jss.2009.02.018 Iseri, 2008, Oxytocin ameliorates skin damage and oxidant gastric injury in rats with thermal trauma, Burns, 34, 361, 10.1016/j.burns.2007.03.022 Iseri, 2005, Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism, Peptides, 26, 483, 10.1016/j.peptides.2004.10.005 Iseri, 2005, Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils, Journal of Surgical Research, 126, 73, 10.1016/j.jss.2005.01.021 Iwasaki, 2015, Chromatin resetting mechanisms preventing transgenerational inheritance of epigenetic states, Frontiers in Plant Science, 6, 380, 10.3389/fpls.2015.00380 Jankowski, 2010, Anti-inflammatory effect of oxytocin in rat myocardial infarction, Basic Research in Cardiology, 105, 205, 10.1007/s00395-009-0076-5 Jia, 2014, High expression of MICA in human kidney cancer tissue and renal cell carcinoma lines, Asian Pacific Journal of Cancer Prevention, 15, 1715, 10.7314/APJCP.2014.15.4.1715 Johnson, 1985, Regulation of lymphokine production by arginine vasopressin and oxytocin: Modulation of lymphocyte function by neurohypophyseal hormones, Journal of Immunology, 135, 773s, 10.4049/jimmunol.135.2.773 Kallus, 2012, The intestinal microbiota and obesity, Journal of Clinical Gastroenterology, 46, 16, 10.1097/MCG.0b013e31823711fd Kamada, 2013, Role of the gut microbiota in the development and function of lymphoid cells, Journal of Immunology, 190, 1389, 10.4049/jimmunol.1203100 Karelina, 2011, Oxytocin mediates social neuroprotection after cerebral ischemia, Stroke, 42, 3606, 10.1161/STROKEAHA.111.628008 Karimi, 2009, Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice, American Journal of Respiratory and Critical Care Medicine, 179, 186, 10.1164/rccm.200806-951OC Kelly, 2016, Brain-gut-microbiota axis: Challenges for translation in psychiatry, Annals of Epidemiology, 26, 366, 10.1016/j.annepidem.2016.02.008 Knobloch, 2014, Evolution of oxytocin pathways in the brain of vertebrates, Frontiers in Behavioral Neuroscience, 8, 31, 10.3389/fnbeh.2014.00031 Kobyliak, 2016, Pathophysiological role of host microbiota in the development of obesity, Nutrition Journal, 15, 43, 10.1186/s12937-016-0166-9 Kokko, 2008, Parental investment, sexual selection and sex ratios, Journal of Evolutionary Biology, 21, 919, 10.1111/j.1420-9101.2008.01540.x Koren, 2012, Host remodeling of the gut microbiome and metabolic changes during pregnancy, Cell, 150, 470, 10.1016/j.cell.2012.07.008 Koren, 2012, Cortisol and corticosterone independence in cortisol-dominant wildlife, General and Comparative Endocrinology, 177, 113, 10.1016/j.ygcen.2012.02.020 Kosfeld, 2005, Oxytocin increases trust in humans, Nature, 435, 673, 10.1038/nature03701 Lakritz, 2014, Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice, International Journal of Cancer, 135, 529, 10.1002/ijc.28702 Lau, 2015, Beyond gut microbiota: Understanding obesity and type 2 diabetes, Hormones (Athens, Greece), 14, 358 Lee, 2008, A conditional knockout mouse line of the oxytocin receptor, Endocrinology, 149, 3256, 10.1210/en.2007-1710 Lee, 2009, Oxytocin: The great facilitator of life, Progress in Neurobiology, 88, 127 Lee, 2010, Has the microbiota played a critical role in the evolution of the adaptive immune system?, Science, 330, 1768, 10.1126/science.1195568 Lefevre, 2016, The two fold role of oxytocin in social developmental disorders: A cause and a remedy?, Neuroscience and Biobehavioral Reviews, 63, 168, 10.1016/j.neubiorev.2016.01.011 Leng, 2016, Intranasal oxytocin: Myths and delusions, Biological Psychiatry, 79, 243, 10.1016/j.biopsych.2015.05.003 Levkovich, 2013, Probiotic bacteria induce a ‘glow of health’, PloS One, 8, e53867, 10.1371/journal.pone.0053867 Lin, 2008, Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun, Inflammatory Bowel Diseases, 14, 1068, 10.1002/ibd.20448 Liu, 2010, Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation, American Journal of Physiology. Gastrointestinal and Liver Physiology, 299, G1087, 10.1152/ajpgi.00124.2010 Liu, 2012, Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine, American Journal of Physiology. Gastrointestinal and Liver Physiology, 302, G608, 10.1152/ajpgi.00266.2011 Livingston, 2010, Gut commensal Lactobacillus reuteri 100–23 stimulates an immunoregulatory response, Immunology and Cell Biology, 88, 99, 10.1038/icb.2009.71 Lokrantz, 1997, Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats, Physiology & Behavior, 62, 347, 10.1016/S0031-9384(97)00021-8 Lorea Baroja, 2007, Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients, Clinical and Experimental Immunology, 149, 470, 10.1111/j.1365-2249.2007.03434.x Maccio, 2010, Oxytocin both increases proliferative response of peripheral blood lymphomonocytes to phytohemagglutinin and reverses immunosuppressive estrogen activity, In Vivo, 24, 157 Maejima, 2011, Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass, Aging (Albany NY), 3, 1169, 10.18632/aging.100408 Maejima, 2009, Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway, Cell Metabolism, 10, 355, 10.1016/j.cmet.2009.09.002 Manichanh, 2012, The gut microbiota in IBD, Nature Reviews. Gastroenterology & Hepatology, 9, 599, 10.1038/nrgastro.2012.152 Marchesi, 2016, The gut microbiota and host health: A new clinical frontier, Gut, 65, 330, 10.1136/gutjnl-2015-309990 Matsuura, 2016, Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats, Neuroscience Letters, 621, 104, 10.1016/j.neulet.2016.04.010 Mayes, 2015, Clinical safety and efficacy of probiotic administration following burn injury, Journal of Burn Care & Research, 36, 92, 10.1097/BCR.0000000000000139 Maynard, 2012, Reciprocal interactions of the intestinal microbiota and immune system, Nature, 489, 231, 10.1038/nature11551 Mccabe, 2013, Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice, Journal of Cellular Physiology, 228, 1793, 10.1002/jcp.24340 Mcfall-Ngai, 2013, Animals in a bacterial world, a new imperative for the life sciences, Proceedings of the National Academy of Sciences of the United States of America, 110, 3229, 10.1073/pnas.1218525110 Mechoud, 2012, Lactobacillus reuteri CRL1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: Involvement of lipid rafts, International Immunopharmacology, 14, 446, 10.1016/j.intimp.2012.08.020 Milani, 2016, The human gut microbiota and its interactive connections to diet, Journal of Human Nutrition and Dietetics, 10.1111/jhn.12371 Million, 2013, Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli, International Journal of Obesity (London), 37, 1460, 10.1038/ijo.2013.20 Million, 2012, Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii, International Journal of Obesity, 36, 817, 10.1038/ijo.2011.153 Moghimian, 2012, The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: Role of oxytocin, Stress, 15, 385, 10.3109/10253890.2011.630436 Molin, 1993, Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines, Journal of Applied Bacteriology, 74, 314, 10.1111/j.1365-2672.1993.tb03031.x Moloney, 2014, The microbiome: Stress, health and disease, Mammalian Genome, 25, 49, 10.1007/s00335-013-9488-5 Morton, 2012, Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats, American Journal of Physiology. Endocrinology and Metabolism, 302, E134, 10.1152/ajpendo.00296.2011 Mozaffarian, 2011, Changes in diet and lifestyle and long-term weight gain in women and men, New England Journal of Medicine, 364, 2392, 10.1056/NEJMoa1014296 Muchmore, 1981, A dual mechanism of action of oxytocin in rat epididymal fat cells, Journal of Biological Chemistry, 256, 365, 10.1016/S0021-9258(19)70144-6 Mullis, 2013, Oxytocin action in the ventral tegmental area affects sucrose intake, Brain Research, 1513, 85, 10.1016/j.brainres.2013.03.026 Murphy, 2010, Composition and energy harvesting capacity of the gut microbiota: Relationship to diet, obesity and time in mouse models, Gut, 59, 1635, 10.1136/gut.2010.215665 Nagao-Kitamoto, 2016, Pathogenic role of the gut microbiota in gastrointestinal diseases, Intestinal Research, 14, 127, 10.5217/ir.2016.14.2.127 Nager, 1999, Experimental demonstration that offspring sex ratio varies with maternal condition, Proceedings of the National Academy of Sciences of the United States of America, 96, 570, 10.1073/pnas.96.2.570 Nation, 2010, Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE−/− mice, Psychosomatic Medicine, 72, 376, 10.1097/PSY.0b013e3181d74c48 Neish, 2009, Microbes in gastrointestinal health and disease, Gastroenterology, 136, 65, 10.1053/j.gastro.2008.10.080 Nieuwdorp, 2014, Role of the microbiome in energy regulation and metabolism, Gastroenterology, 146, 1525, 10.1053/j.gastro.2014.02.008 Niv, 2005, The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome—A double blind, placebo-controlled, randomized study, Clinical Nutrition, 24, 925, 10.1016/j.clnu.2005.06.001 Nomura, 2007, Foxp3 and aire in thymus-generated Treg cells: A link in self-tolerance, Nature Immunology, 8, 333, 10.1038/ni0407-333 Noverr, 2004, Does the microbiota regulate immune responses outside the gut?, Trends in Microbiology, 12, 562, 10.1016/j.tim.2004.10.008 Oliva, 2012, Randomised clinical trial: The effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis, Alimentary Pharmacology & Therapeutics, 35, 327, 10.1111/j.1365-2036.2011.04939.x Olson, 1991, Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats, Peptides, 12, 113, 10.1016/0196-9781(91)90176-P Olszewski, 2010, Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake, Endocrinology, 151, 4736, 10.1210/en.2010-0151 O'toole, 2015, Gut microbiota and aging, Science, 350, 1214, 10.1126/science.aac8469 Peral, 2009, Bacteriotherapy with Lactobacillus plantarum in burns, International Wound Journal, 6, 73, 10.1111/j.1742-481X.2008.00577.x Petersson, 2001, Oxytocin decreases carrageenan induced inflammation in rats, Peptides, 22, 1479, 10.1016/S0196-9781(01)00469-7 Pittman, 2011, A neuro-endocrine-immune symphony, Journal of Neuroendocrinology, 23, 1296, 10.1111/j.1365-2826.2011.02176.x Poggi, 2007, C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet, Diabetologia, 50, 1267, 10.1007/s00125-007-0654-8 Poutahidis, 2016, Commensal bacteria modulate the tumor microenvironment, Cancer Letters, 380, 356, 10.1016/j.canlet.2015.12.028 Poutahidis, 2013, Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin, PloS One, 8, e78898, 10.1371/journal.pone.0078898 Poutahidis, 2014, Gut microbiota and the paradox of cancer immunotherapy, Frontiers in Immunology, 5, 157, 10.3389/fimmu.2014.00157 Poutahidis, 2013, Microbial reprogramming inhibits Western diet-associated obesity, PloS One, 8, e68596, 10.1371/journal.pone.0068596 Poutahidis, 2014, Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice, PloS One, 9, e84877, 10.1371/journal.pone.0084877 Poutahidis, 2015, Dietary microbes modulate transgenerational cancer risk, Cancer Research, 75, 1197, 10.1158/0008-5472.CAN-14-2732 Pryke, 2012, Mothers adjust offspring sex to match the quality of the rearing environment, Proceedings of the Biological Sciences, 279, 4051, 10.1098/rspb.2012.1351 Pryke, 2011, Context-dependent sex allocation: Constraints on the expression and evolution of maternal effects, Evolution, 65, 2792, 10.1111/j.1558-5646.2011.01391.x Qian, 2014, Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients, Journal of Clinical Endocrinology and Metabolism, 99, 4683, 10.1210/jc.2014-2206 Qiao, 2015, Effects of different lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model, Journal of Functional Foods, 14, 424, 10.1016/j.jff.2015.02.013 Qin, 2009, Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats, Neurogastroenterology and Motility, 21, 430, 10.1111/j.1365-2982.2009.01282.x Rao, 2007, Breast cancer: Should gastrointestinal bacteria be on our radar screen?, Cancer Research, 67, 847, 10.1158/0008-5472.CAN-06-3468 Rautava, 2012, Microbial contact during pregnancy, intestinal colonization and human disease, Nature Reviews. Gastroenterology & Hepatology, 9, 565, 10.1038/nrgastro.2012.144 Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science, 341, 1241214, 10.1126/science.1241214 Rinaman, 2005, Dehydration anorexia is attenuated in oxytocin-deficient mice, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288, R1791, 10.1152/ajpregu.00860.2004 Rook, 2010, 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis, Clinical and Experimental Immunology, 160, 70, 10.1111/j.1365-2249.2010.04133.x Rook, 2013, Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health, Proceedings of the National Academy of Sciences of the United States of America, 110, 18360, 10.1073/pnas.1313731110 Rosenberg, 2011, Symbiosis and development: The hologenome concept, Birth Defects Research. Part C, Embryo Today, 93, 56, 10.1002/bdrc.20196 Round, 2009, The gut microbiota shapes intestinal immune responses during health and disease, Nature Reviews. Immunology, 9, 313, 10.1038/nri2515 Salim, 2013, Supplementation of direct-fed microbials as an alternative to antibiotic on growth performance, immune response, cecal microbial population, and ileal morphology of broiler chickens, Poultry Science, 92, 2084, 10.3382/ps.2012-02947 Sandrini, 2015, Microbial endocrinology: Host-bacteria communication within the gut microbiome, Journal of Endocrinology, 225, R21, 10.1530/JOE-14-0615 Schreiber, 2009, Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions, American Journal of Physiology. Gastrointestinal and Liver Physiology, 296, G534, 10.1152/ajpgi.90470.2008 Shen, 2015, Neuroscience: The hard science of oxytocin, Nature, 522, 410, 10.1038/522410a Sherwin, 2016, A gut (microbiome) feeling about the brain, Current Opinion in Gastroenterology, 32, 96, 10.1097/MOG.0000000000000244 Shoelson, 2007, Obesity, inflammation, and insulin resistance, Gastroenterology, 132, 2169, 10.1053/j.gastro.2007.03.059 Simon, 2015, Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: A proof of concept, Diabetes Care, 38, 1827, 10.2337/dc14-2690 Singh, 2015, Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet, International Journal of Food Science and Nutrition, 66, 71, 10.3109/09637486.2014.953450 Smits, 2005, Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin, Journal of Allergy and Clinical Immunology, 115, 1260, 10.1016/j.jaci.2005.03.036 Smolinsky, 2009, Analysis of grooming behavior and its utility in studying animal stress, anxiety, and depression, Neuromethods, 42, 21, 10.1007/978-1-60761-303-9_2 Sommer, 2013, The gut microbiota—Masters of host development and physiology, Nature Reviews. Microbiology, 11, 227, 10.1038/nrmicro2974 Sommer, 2016, The gut microbiota modulates energy metabolism in the hibernating brown bear Ursus arctos, Cell Reports, 14, 1655, 10.1016/j.celrep.2016.01.026 Sonnenburg, 2016, Diet-induced extinctions in the gut microbiota compound over generations, Nature, 529, 212, 10.1038/nature16504 Souza-Moreira, 2011, Neuropeptides as pleiotropic modulators of the immune response, Neuroendocrinology, 94, 89, 10.1159/000328636 Spetter, 2015, Intranasal neuropeptide administration to target the human brain in health and disease, Molecular Pharmaceutics, 12, 2767, 10.1021/acs.molpharmaceut.5b00047 Stilling, 2016, The brain's Geppetto-microbes as puppeteers of neural function and behaviour?, Journal of Neurovirology, 22, 14, 10.1007/s13365-015-0355-x Sun, 2016, High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches, Nutrition, 32, 265, 10.1016/j.nut.2015.08.020 Sun, 2016, Functions of vasopressin and oxytocin in bone mass regulation, Proceedings of the National Academy of Sciences of the United States of America, 113, 164, 10.1073/pnas.1523762113 Szajewska, 2014, Meta-analysis: Lactobacillus reuteri strain DSM 17938 (and the original strain ATCC 55730) for treating acute gastroenteritis in children, Beneficial Microbes, 5, 285, 10.3920/BM2013.0056 Szeto, 2008, Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells, American Journal of Physiology. Endocrinology and Metabolism, 295, E1495, 10.1152/ajpendo.90718.2008 Takayanagi, 2008, Oxytocin receptor-deficient mice developed late-onset obesity, Neuroreport, 19, 951, 10.1097/WNR.0b013e3283021ca9 Tamma, 2009, Oxytocin is an anabolic bone hormone, Proceedings of the National Academy of Sciences of the United States of America, 106, 7149, 10.1073/pnas.0901890106 Taranto, 1998, Evidence for hypocholesterolemic effect of Lactobacillus reuteri in hypercholesterolemic mice, Journal of Dairy Science, 81, 2336, 10.3168/jds.S0022-0302(98)70123-7 Taylor, 2014, Oxytocin treatment in pediatric populations, Frontiers in Behavioral Neuroscience, 8, 360, 10.3389/fnbeh.2014.00360 Ting, 2015, Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function, British Journal of Nutrition, 114, 706, 10.1017/S0007114515002469 Tremaroli, 2012, Functional interactions between the gut microbiota and host metabolism, Nature, 489, 242, 10.1038/nature11552 Trivers, 1973, Natural selection of parental ability to vary the sex ratio of offspring, Science, 179, 90, 10.1126/science.179.4068.90 Turnbaugh, 2009, A core gut microbiome in obese and lean twins, Nature, 457, 480, 10.1038/nature07540 Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414 Urbanska, 2016, Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children, Alimentary Pharmacology & Therapeutics, 43, 1025, 10.1111/apt.13590 Uvnas-Moberg, 1998, Oxytocin may mediate the benefits of positive social interaction and emotions, Psychoneuroendocrinology, 23, 819, 10.1016/S0306-4530(98)00056-0 Varian, 2016, Beneficial bacteria inhibit cachexia, Oncotarget, 7, 11803, 10.18632/oncotarget.7730 Varian, 2016, Beneficial dog bacteria up-regulate oxytocin and lower risk of obesity, Journal of Probiotics & Health, 4, 1 Varian, 2014, Beneficial bacteria stimulate youthful thyroid gland activity, Journal of Obesity and Weight Loss Therapy, 4, 1 Viero, 2010, REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy, CNS Neuroscience & Therapeutics, 16, e138, 10.1111/j.1755-5949.2010.00185.x Vijay-Kumar, 2010, Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5, Science, 328, 228, 10.1126/science.1179721 Vila, 2014, Immune cell toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis, Cell Reports, 7, 1116, 10.1016/j.celrep.2014.03.062 Vitalo, 2009, Nest making and oxytocin comparably promote wound healing in isolation reared rats, PloS One, 4, e5523, 10.1371/journal.pone.0005523 Walter, 2011, Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm, Proceedings of the National Academy of Sciences of the United States of America, 108, 4645, 10.1073/pnas.1000099107 Walters, 2011, PrimerProspector: De novo design and taxonomic analysis of barcoded polymerase chain reaction primers, Bioinformatics, 27, 1159, 10.1093/bioinformatics/btr087 Wang, 2015, Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity, Journal of Neuroimmunology, 289, 152, 10.1016/j.jneuroim.2015.11.001 Welch, 2014, Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice, American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, G848, 10.1152/ajpgi.00176.2014 Wong, 2013, From germ theory to germ therapy: Skin microbiota, chronic wounds, and probiotics, Plastic and Reconstructive Surgery, 132, 854e, 10.1097/PRS.0b013e3182a3c11e Woting, 2016, The intestinal microbiota in metabolic disease, Nutrients, 8, 202, 10.3390/nu8040202 Wu, 2003, Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats, Naunyn-Schmiedeberg’s Archives of Pharmacology, 367, 406, 10.1007/s00210-003-0690-y Yanai, 2011, Is rate of skin wound healing associated with aging or longevity phenotype?, Biogerontology, 12, 591, 10.1007/s10522-011-9343-6 Yang, 2013, Nonsocial functions of hypothalamic oxytocin, ISRN Neuroscience, 2013, 179272, 10.1155/2013/179272 Yoo, 2016, Probiotics and prebiotics: Present status and future perspectives on metabolic disorders, Nutrients, 8, 173, 10.3390/nu8030173 Yoshida, 2009, Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice, Journal of Neuroscience, 29, 2259, 10.1523/JNEUROSCI.5593-08.2009 Yosten, 2010, The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298, R1642, 10.1152/ajpregu.00804.2009 Young, 2009, Vasopressin/oxytocin and receptors Yuan, 2016, Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice, Journal of Neuroinflammation, 13, 77, 10.1186/s12974-016-0541-7 Zhang, 2011, Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance, Neuron, 69, 523, 10.1016/j.neuron.2010.12.036 Zhang, 2011, Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment, American Journal of Physiology. Endocrinology and Metabolism, 301, E1004, 10.1152/ajpendo.00196.2011 Zhang, 2015, Loss of bone and Wnt10b expression in male type 1 diabetic mice is blocked by the probiotic Lactobacillus reuteri, Endocrinology, 156, 3169, 10.1210/EN.2015-1308 Zhang, 2013, Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models, PloS One, 8, 1 Zingg, 2003, The oxytocin receptor, Trends in Endocrinology and Metabolism, 14, 222, 10.1016/S1043-2760(03)00080-8