Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life

Mucosal Immunology - Tập 12 - Trang 378-389 - 2019
Takashi Senda1,2, Pranay Dogra1,3, Tomer Granot1,3,4, Kazuhiro Furuhashi1, Mark E. Snyder1,3, Dustin J. Carpenter1,2, Peter A. Szabo1,3, Puspa Thapa1,3, Michelle Miron1,5, Donna L. Farber1,2,5
1Columbia Center for Translational Immunology, Columbia University Medical Center, 10032, New York, NY, USA
2Department of Surgery, Columbia University Medical Center, 10032, New York, NY, USA
3Department of Medicine, Columbia University Medical Center, 10032, New York, NY, USA
4Compugen, San Francisco, CA, USA
5Department of Microbiology and Immunology, Columbia University Medical Center, 10032, New York, NY, USA

Tài liệu tham khảo

Gupta, 2011, The prevalence, severity, and distribution of childhood food allergy in the United States, Pediatrics, 128, e9, 10.1542/peds.2011-0204 Bernstein, 2006, The epidemiology of inflammatory bowel disease in Canada: a population-based study, Am. J. Gastroenterol., 101, 1559, 10.1111/j.1572-0241.2006.00603.x Haggar, 2009, Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors, Clin. Colon Rectal Surg., 22, 191, 10.1055/s-0029-1242458 Hamada, 2002, Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine, J. Immunol., 168, 57, 10.4049/jimmunol.168.1.57 Peterson, 2014, Intestinal epithelial cells: regulators of barrier function and immune homeostasis, Nat. Rev. Immunol., 14, 141, 10.1038/nri3608 Pabst, 2005, Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes, Eur. J. Immunol., 35, 98, 10.1002/eji.200425432 Gustafson, 2014, Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy, Mucosal Immunol., 7, 467, 10.1038/mi.2013.64 Pearson, 2012, Lymphoid microenvironments and innate lymphoid cells in the gut, Trends Immunol., 33, 289, 10.1016/j.it.2012.04.004 Chassaing, 2011, Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae, J. Clin. Invest., 121, 966, 10.1172/JCI44632 Farstad, 1994, Heterogeneity of M-cell-associated B and T cells in human Peyer's patches, Immunology, 83, 457 Thome, 2014, Spatial map of human T cell compartmentalization and maintenance over decades of life, Cell, 159, 814, 10.1016/j.cell.2014.10.026 Masopust, 2006, Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population, J. Immunol., 176, 2079, 10.4049/jimmunol.176.4.2079 Masopust, 2010, Dynamic T cell migration program provides resident memory within intestinal epithelium, J. Exp. Med., 207, 553, 10.1084/jem.20090858 Kumar, 2017, Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites, Cell Rep., 20, 2921, 10.1016/j.celrep.2017.08.078 Sakaguchi, 2008, Regulatory T cells and immune tolerance, Cell, 133, 775, 10.1016/j.cell.2008.05.009 Coombes, 2005, Regulatory T cells and intestinal homeostasis, Immunol. Rev., 204, 184, 10.1111/j.0105-2896.2005.00250.x Izcue, 2009, Regulatory lymphocytes and intestinal inflammation, Annu. Rev. Immunol., 27, 313, 10.1146/annurev.immunol.021908.132657 Santiago, 2011, Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa, Immunobiology, 216, 1085, 10.1016/j.imbio.2011.05.007 Carpenter, 2018, Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation, Am. J. Transplant., 18, 74, 10.1111/ajt.14434 Thome, 2016, Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues, Nat. Med., 22, 72, 10.1038/nm.4008 Sathaliyawala, 2013, Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets, Immunity, 38, 187, 10.1016/j.immuni.2012.09.020 Granot, 2017, Dendritic cells display subset and tissue-specific maturation dynamics over human life, Immunity, 46, 504, 10.1016/j.immuni.2017.02.019 Gordon, 2017, Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection, J. Exp. Med., 214, 651, 10.1084/jem.20160758 Cornes, 1965, Number, size, and distribution of Peyer's patches in the human small intestine: part I. The development of Peyer's patches, Gut, 6, 225, 10.1136/gut.6.3.225 Lazuardi, 2005, Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes, Immunology, 114, 37, 10.1111/j.1365-2567.2004.02006.x Moghaddami, 1998, Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine, Gastroenterology, 115, 1414, 10.1016/S0016-5085(98)70020-4 Sallusto, 2004, Central memory and effector memory T cell subsets: function, generation, and maintenance, Annu. Rev. Immunol., 22, 745, 10.1146/annurev.immunol.22.012703.104702 Sallusto, 1999, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions [see comments], Nature, 401, 708, 10.1038/44385 Laidlaw, 2014, CD4+T cell help guides formation of CD103+lung-resident memory CD8+T cells during influenza viral infection, Immunity, 41, 633, 10.1016/j.immuni.2014.09.007 Shiow, 2006, CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs, Nature, 440, 540, 10.1038/nature04606 Liu, 2006, CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+T reg cells, J. Exp. Med., 203, 1701, 10.1084/jem.20060772 Du Toit, 2015, Randomized trial of peanut consumption in infants at risk for peanut allergy, N. Engl. J. Med., 372, 803, 10.1056/NEJMoa1414850 Capper, 2018, DNA methylation-based classification of central nervous system tumours, Nature, 555, 469, 10.1038/nature26000 Mobadersany, 2018, Predicting cancer outcomes from histology and genomics using convolutional networks, Proc. Natl. Acad. Sci. USA, 115, E2970, 10.1073/pnas.1717139115 Poplin, 2018, Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning, Nat. Biomed. Eng., 2, 158, 10.1038/s41551-018-0195-0 Hovhannisyan, 2011, Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases, Gastroenterology, 140, 957, 10.1053/j.gastro.2010.12.002 Stenstad, 2006, Gut-associated lymphoid tissue-primed CD4+T cells display CCR9-dependent and -independent homing to the small intestine, Blood, 107, 3447, 10.1182/blood-2005-07-2860 Thome, J. J., et al. Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1, eaah6506 (2016). den Braber, 2012, Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans, Immunity, 36, 288, 10.1016/j.immuni.2012.02.006 Halsey, 1985, The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age, Bull. World Health Organ, 63, 1151 Dubois, 2009, Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance, Gastroenterology, 137, 1019, 10.1053/j.gastro.2009.03.055 Goubier, 2008, Plasmacytoid dendritic cells mediate oral tolerance, Immunity, 29, 464, 10.1016/j.immuni.2008.06.017 Morisset, 2007, Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy, Eur. Ann. Allergy Clin. Immunol., 39, 12 Longo, 2008, Specific oral tolerance induction in children with very severe cow's milk-induced reactions, J. Allergy Clin. Immunol., 121, 343, 10.1016/j.jaci.2007.10.029 Skripak, 2008, A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy, J. Allergy Clin. Immunol., 122, 1154, 10.1016/j.jaci.2008.09.030 Esterhazy, 2016, Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance, Nat. Immunol., 17, 545, 10.1038/ni.3408 Statsmodels: Econometric and Statistical Modeling with Python. Proc. 9th Python Science Conf. (SCIPY 2010) (2010). Pedregosa, 2011, Scikit-learn: machine learning in Python, J. Mach. Learn. Res., 12, 2825