Microalbuminuria as a target to improve cardiovascular and renal outcomes in diabetic patients
Tóm tắt
Microalbuminuria has been shown to be a risk factor for adverse renal and cardiovascular outcomes in patients with diabetes mellitus. This risk appears to increase with higher levels of albuminuria. There is also evidence that reducing the level of albuminuria improves these outcomes. This review focuses on the most recent advances in this area and reviews literature over the past year on this topic.
Tài liệu tham khảo
Yokoyama H, Kawai K, Kobayashi M: Microalbuminuria is common in Japanese type 2 diabetic patients. Diabetes Care 2007, 30:989–992.
Lewis EJ, Hunsicker LG, Clarke WR, et al.: Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001, 345:851–860.
Brenner BM, Cooper ME, de Zeeuw D, et al.: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001, 345:861–890.
Anavekar NS, Gans DJ, Berl T, et al.: Predictors of cardiovascular events in patients with type 2 diabetic nephropathy and hypertension: a case for albuminuria. Kidney Int 2004, 66:S50–S55.
de Zeeuw D, Remuzzi G, Parving HH, et al.: Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation 2004, 110:921–927.
Gerstein HC, Mann JFE, Yi Q, et al.: Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001, 286:421–426.
Araki S, Haneda M, Koya D, et al.: Reduction in micro-albuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes. Diabetes 2007, 56:1727–1730.
American Diabetes Association: Standards of medical care. Diabetes Care 2005, 28Suppl 1):S4–S36.
Arnlov J, Evans J, Meigs J, et al.: Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals, the Framingham heart study. Circulation 2005, 112:969–975.
Comper WD, Osicka TM: Albumin-like material in urine. Kidney Int Suppl 2004, 92:S65–S66.
Rao PV, Lu X, Standley M, et al.: Proteomic identification of urinary biomarkers of diabetic nephropathy. Diabetes Care 2007, 30:629–637.
Otu HH, Can H, Spentzos D, et al.: Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy. Diabetes Care 2007, 30:638–643.
Schmieder RE, Delles C, Mimran A, et al.: Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care 2007, 30:1351–1356.
Tamsma JT, van den Born J, Bruijn JA, et al.: Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparan sulfate in the glomerular basement membrane. Diabetologia 1994, 37:313–320.
Van der Pijl JW, Daha MR, Van Den Born J, et al.: Extracellular matrix in human diabetic nephropathy: reduced expression of heparan sulfate in skin basement membrane. Diabetologia 1998, 41:791–798.
Gambaro G, Kinalska I, Oksa A, et al.: Oral sulodexide reduced albuminuria in microalbuminuric and macroalbuminuria type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial. J Am Soc Nephrol 2002, 13:1615–1625.
Gambaro G, Cavazzana AO, Luzi P, et al.: Glycosaminoglycans prevent morphological renal alterations and albuminuria in diabetic rats. Kidney Int 1992, 42:285–291.
Yokokawa K, Kohno M, Mandal AK, et al.: Heparin suppresses endothelin-1 (ET-1) peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats. J Am Soc Nephrol 1994, 4:1683–1689.
Reantragoon S, Arrigo LM, Seoud MA, et al.: Specific heparin fractions suppress ET-1 production in cultured human umbilical vein endothelial cells. Arch Biochem Biophys 1994, 314:315–322.
Ceol M, Vianello D, Schleicher E, et al.: Heparin reduces glomerular infiltration and TGF-beta protein expression by macrophages in puromycin glomerulosclerosis. J Nephrol 2003, 16:210–218.
Sulikowska B, Olejniczak H, Muszynska M, et al.: Effect of sulodexide on albuminuria, NAG excretion and glomerular filtration response to dopamine in diabetic patients. Am J Nephrology 2006, 26:621–628.
Fogari R, Derosa G, Zoppi A, et al.: Effect of telmisartanamlodipine combination at different doses on urinary albumin excretion in hypertensive diabetic patients with microalbuminuria. Am J Hypertens 2007, 20:417–422.
Shiga Microalbuminuria Reduction Trial (SMART) Group: Reduction of microalbuminuria in patients with type 2 diabetes. Diabetes Care 2007, 30:1581–1583.
Bakris GL, Ruilope LM, McMorn SO, et al.: Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria. J Hypertension 2006, 24:2047–2055.
Lazarevic G, Antic S, Vlahovic P, et al.: Effects of aerobic exercise on microalbuminuria and enzymuria in type 2 diabetic patients. Renal Failure 2007, 29:199–205.
Saito K, Sone H, Kawai K, et al.: Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their development of microalbuminuria. Diabetes Care 2007, 30:1286–1288.