MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF-β Signaling

Bernstein, 2003, Dicer is essential for mouse development, Nat. Genet., 35, 215, 10.1038/ng1253 Betel, 2008, The microRNA.org resource: targets and expression, Nucleic Acids Res., 36, D149, 10.1093/nar/gkm995 Chandran, 2014, The TGF-beta-inducible miR-23a cluster attenuates IFN-gamma levels and antigen-specific cytotoxicity in human CD8(+) T cells, J. Leukoc. Biol., 96, 633, 10.1189/jlb.3A0114-025R Chhabra, 2010, Cooperative and individualistic functions of the microRNAs in the miR-23a∼27a∼24-2 cluster and its implication in human diseases, Mol. Cancer, 9, 232, 10.1186/1476-4598-9-232 Drabsch, 2012, TGF-beta signalling and its role in cancer progression and metastasis, Cancer Metastasis Rev., 31, 553, 10.1007/s10555-012-9375-7 Evans, 1981, Establishment in culture of pluripotential cells from mouse embryos, Nature, 292, 154, 10.1038/292154a0 Fei, 2010, Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells, Cell Res., 20, 1306, 10.1038/cr.2010.158 Gangaraju, 2009, MicroRNAs: key regulators of stem cells, Nat. Rev. Mol. Cell Biol., 10, 116, 10.1038/nrm2621 Hailesellasse Sene, 2007, Gene function in early mouse embryonic stem cell differentiation, BMC Genomics, 8, 85, 10.1186/1471-2164-8-85 Hao, 2011, MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer, Biochem. Biophys. Res. Commun., 406, 552, 10.1016/j.bbrc.2011.02.086 Hassan, 2010, A network connecting Runx2, SATB2, and the miR-23a∼27a∼24-2 cluster regulates the osteoblast differentiation program, Proc. Natl. Acad. Sci. USA, 107, 19879, 10.1073/pnas.1007698107 Hay, 2004, Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells, Stem Cells, 22, 225, 10.1634/stemcells.22-2-225 He, 2014, MiR-23a functions as a tumor suppressor in osteosarcoma, Cell Physiol. Biochem., 34, 1485, 10.1159/000366353 Hu, 2010, ATM is down-regulated by N-Myc-regulated microRNA-421, Proc. Natl. Acad. Sci. USA, 107, 1506, 10.1073/pnas.0907763107 Kozomara, 2014, miRBase: annotating high confidence microRNAs using deep sequencing data, Nucleic Acids Res., 42, D68, 10.1093/nar/gkt1181 Lee, 2011, Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions, PLoS Genet., 7, e1002130, 10.1371/journal.pgen.1002130 Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15, 10.1016/j.cell.2004.12.035 Marchand, 2012, miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells, PLoS One, 7, e44532, 10.1371/journal.pone.0044532 Melton, 2010, Opposing microRNA families regulate self-renewal in mouse embryonic stem cells, Nature, 463, 621, 10.1038/nature08725 Moustakas, 2009, The regulation of TGFbeta signal transduction, Development, 136, 3699, 10.1242/dev.030338 Musto, 2014, miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis, Cell Death Differ., 22, 1047, 10.1038/cdd.2014.198 Nagpal, 2014, miR-191: an emerging player in disease biology, Front. Genet., 5, 99, 10.3389/fgene.2014.00099 Ng, 2011, The transcriptional and signalling networks of pluripotency, Nat. Cell Biol., 13, 490, 10.1038/ncb0511-490 Niakan, 2010, Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal, Genes Dev., 24, 312, 10.1101/gad.1833510 Oshimori, 2012, The harmonies played by TGF-beta in stem cell biology, Cell Stem Cell, 11, 751, 10.1016/j.stem.2012.11.001 Pekarsky, 2015, Role of miR-15/16 in CLL, Cell Death Differ., 22, 6, 10.1038/cdd.2014.87 Strumpf, 2005, Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst, Development, 132, 2093, 10.1242/dev.01801 Tay, 2008, MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation, Nature, 455, 1124, 10.1038/nature07299 Wang, 2007, DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal, Nat. Genet., 39, 380, 10.1038/ng1969 Ying, 2003, BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3, Cell, 115, 281, 10.1016/S0092-8674(03)00847-X Zhang, 2010, Distinct functions of BMP4 during different stages of mouse ES cell neural commitment, Development, 137, 2095, 10.1242/dev.049494