MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc

Pollak, 2012, The insulin and insulin-like growth factor receptor family in neoplasia: An update, Nat Rev Cancer, 12, 159, 10.1038/nrc3215

Cornellà, 2011, Molecular pathogenesis of hepatocellular carcinoma, Alcohol Clin Exp Res, 35, 821, 10.1111/j.1530-0277.2010.01406.x

Cervello, 2012, Targeted therapy for hepatocellular carcinoma: Novel agents on the horizon, Oncotarget, 3, 236, 10.18632/oncotarget.466

Chang, 2013, In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma, Anticancer Drugs, 24, 251, 10.1097/CAD.0b013e32835ba289

Cohen, 2005, Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871, Clin Cancer Res, 11, 2063, 10.1158/1078-0432.CCR-04-1070

Lin, 2007, Inhibition of hepatocellular carcinoma growth by antisense oligonucleotides to type I insulin-like growth factor receptor in vitro and in an orthotopic model, Hepatol Res, 37, 366, 10.1111/j.1872-034X.2007.00055.x

Rodon, 2008, Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials, Mol Cancer Ther, 7, 2575, 10.1158/1535-7163.MCT-08-0265

Chen, 2008, Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells, Cancer Res, 68, 6698, 10.1158/0008-5472.CAN-08-0257

van Malenstein, 2013, Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth, Cancer Lett, 329, 74, 10.1016/j.canlet.2012.10.021

Tai, 2012, Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3, Mol Cancer Ther, 11, 452, 10.1158/1535-7163.MCT-11-0412

Gedaly, 2010, PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways, Anticancer Res, 30, 4951

O'Reilly, 2006, mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt, Cancer Res, 66, 1500, 10.1158/0008-5472.CAN-05-2925

Zitzmann, 2010, Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease, Cancer Lett, 295, 100, 10.1016/j.canlet.2010.02.018

Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, 19, 92, 10.1101/gr.082701.108

Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15, 10.1016/j.cell.2004.12.035

Pillai, 2007, Repression of protein synthesis by miRNAs: How many mechanisms?, Trends Cell Biol, 17, 118, 10.1016/j.tcb.2006.12.007

Lan, 2011, Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A), Int J Cancer, 128, 319, 10.1002/ijc.25336

Croce, 2009, Causes and consequences of microRNA dysregulation in cancer, Nat Rev Genet, 10, 704, 10.1038/nrg2634

He, 2007, A microRNA component of the p53 tumour suppressor network, Nature, 447, 1130, 10.1038/nature05939

El Tayebi, 2012, miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma, FEBS Lett, 586, 3309, 10.1016/j.febslet.2012.06.054

Law, 2012, MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma, Carcinogenesis, 33, 1134, 10.1093/carcin/bgs130

Li, 2011, MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma, J Biol Chem, 286, 36677, 10.1074/jbc.M111.270561

Peng, 2013, Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer, Proc Natl Acad Sci USA, 110, 15043, 10.1073/pnas.1307107110

Mazzaferro, 1996, Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis, N Engl J Med, 334, 693, 10.1056/NEJM199603143341104

El Tayebi, 2013, Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern, Biochem Biophys Res Commun, 434, 421, 10.1016/j.bbrc.2013.04.003

De Meyts, 2004, Insulin and its receptor: Structure, function and evolution, Bioessays, 26, 1351, 10.1002/bies.20151

Durzyńska, 2014, IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review), Oncol Rep, 32, 2295, 10.3892/or.2014.3505

Shaw, 2005, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin, Science, 310, 1642, 10.1126/science.1120781

Oh, 2011, Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer, Clin Cancer Res, 17, 2657, 10.1158/1078-0432.CCR-10-3152

Wang, 2014, Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer, Oncogene, 33, 1181, 10.1038/onc.2013.42

Small, 2010, Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486, Proc Natl Acad Sci USA, 107, 4218, 10.1073/pnas.1000300107

Pang, 2014, Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer, Mol Cancer, 13, 240, 10.1186/1476-4598-13-240

Huang, 2015, MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1, FEBS J, 282, 579, 10.1111/febs.13167

Ali, 2012, MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer, Br J Cancer, 107, 1354, 10.1038/bjc.2012.383

Namløs, 2012, Modulation of the osteosarcoma expression phenotype by microRNAs, PLoS One, 7, e48086, 10.1371/journal.pone.0048086

Lim, 2012, Hepatitis C virus Core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation, Cancer Lett, 321, 154, 10.1016/j.canlet.2012.01.044

Dong, 2014, Aberrant DNA methylation in hepatocellular carcinoma tumor suppression (Review), Oncol Lett, 8, 963, 10.3892/ol.2014.2301

Pourdehnad, 2013, Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers, Proc Natl Acad Sci USA, 110, 11988, 10.1073/pnas.1310230110

Mazzoletti, 2011, Combination of PI3K/mTOR inhibitors: Antitumor activity and molecular correlates, Cancer Res, 71, 4573, 10.1158/0008-5472.CAN-10-4322

Floc'h, 2012, Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model, Cancer Res, 72, 4483, 10.1158/0008-5472.CAN-12-0283

Ragusa, 2010, Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment, Mol Cancer Ther, 9, 3396, 10.1158/1535-7163.MCT-10-0137

Song, 2013, miR-486 sustains NF-kB activity by disrupting multiple NF-kB-negative feedback loops, Cell Res, 23, 274, 10.1038/cr.2012.174