MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

DP Bartel, 2009, MicroRNAs: target recognition and regulatory functions, Cell, 136, 215, 10.1016/j.cell.2009.01.002

RC Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, 19, 92, 10.1101/gr.082701.108

H Guo, 2010, Mammalian microRNAs predominantly act to decrease target mRNA levels, Nature, 466, 835, 10.1038/nature09267

W Filipowicz, 2008, Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight, Nat Rev Genet, 9, 102, 10.1038/nrg2290

R Garzon, 2008, MicroRNAs in normal and malignant hematopoiesis, Curr Opin Hematol, 15, 352, 10.1097/MOH.0b013e328303e15d

U Bissels, 2012, MicroRNAs are shaping the hematopoietic landscape, Haematologica, 97, 160, 10.3324/haematol.2011.051730

JC Byon, 2012, MicroRNAs: Allies or foes in erythropoiesis?, J Cell Physiol, 227, 7, 10.1002/jcp.22729

CH Lawrie, 2010, microRNA expression in erythropoiesis and erythroid disorders, Br J Haematol, 150, 144, 10.1111/j.1365-2141.2009.07978.x

KD Rasmussen, 2010, The miR-144/451 locus is required for erythroid homeostasis, J Exp Med, 207, 1351, 10.1084/jem.20100458

KD Rasmussen, 2011, The miR-144/451eGFP allele, a novel tool for resolving the erythroid potential of hematopoietic precursors, Blood, 118, 2988, 10.1182/blood-2011-04-350728

J Lu, 2008, MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors, Dev Cell, 14, 843, 10.1016/j.devcel.2008.03.012

N Felli, 2005, MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation, Proc Natl Acad Sci USA, 102, 18081, 10.1073/pnas.0506216102

N Felli, 2009, MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis, Haematologica, 94, 479, 10.3324/haematol.2008.002345

J Lu, 2005, MicroRNA expression profiles classify human cancers, Nature, 435, 834, 10.1038/nature03702

DE Bauer, 2012, Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders, Blood, 120, 2945, 10.1182/blood-2012-06-292078

VG Sankaran, 2010, Advances in the understanding of haemoglobin switching, Br J Haematol, 149, 181, 10.1111/j.1365-2141.2010.08105.x

N Bianchi, 2009, Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression, BMB Rep, 42, 493, 10.5483/BMBRep.2009.42.8.493

SJ Noh, 2009, Let-7 microRNAs are developmentally regulated in circulating human erythroid cells, J Transl Med, 7, 98, 10.1186/1479-5876-7-98

M Gabbianelli, 2010, Mechanism of human Hb switching: a possible role of the kit receptor/miR 221–222 complex, Haematologica, 95, 1253, 10.3324/haematol.2009.018259

VG Sankaran, 2011, MicroRNA-15a and -16–1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13, Proc Natl Acad Sci USA, 108, 1519, 10.1073/pnas.1018384108

I Azzouzi, 2011, MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis, PLoS One, 6(7), e22838, 10.1371/journal.pone.0022838

VG Sankaran, 2008, Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A, Science, 322, 1839, 10.1126/science.1165409

VG Sankaran, 2009, Developmental and species-divergent globin switching are driven by BCL11A, Nature, 460, 1093, 10.1038/nature08243

E Satterwhite, 2001, The BCL11 gene family: involvement of BCL11A in lymphoid malignancies, Blood, 98, 3413, 10.1182/blood.V98.12.3413

P Liu, 2003, Bcl11a is essential for normal lymphoid development, Nat Immunol, 4, 525, 10.1038/ni925

SL Thein, 2007, Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults, Proc Natl Acad Sci USA, 104, 11346, 10.1073/pnas.0611393104

N Emambokus, 2003, Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb, EMBO J, 22, 4478, 10.1093/emboj/cdg434

J Jiang, 2006, cMYB is involved in the regulation of fetal hemoglobin production in adults, Blood, 108, 1077, 10.1182/blood-2006-01-008912

Sankaran VG (2011) Target therapeutic strategies for fetal hemoglobin induction. Hematology Am Soc Hematol Educ Program. 2011; 459–65. Review.

J Xu, 2010, Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6, Genes Dev, 24, 783, 10.1101/gad.1897310

N Felli, 2010, Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states, BMC Syst Biol, 16, 4

M Gabbianelli, 2000, Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose dependent fetal hemoglobin reactivation potentiated by sodiumbutyrate, Blood, 95, 3555, 10.1182/blood.V95.11.3555

M Gabbianelli, 2008, Effective erythropoiesis and HbF reactivation induced by kit ligand in beta-thalassemia, Blood, 111, 421, 10.1182/blood-2007-06-097550

L Leone, 1985, Reversed-phase high-performance liquid chromatography of human haemoglobin chains, J Chromatogr, 321, 407, 10.1016/S0021-9673(01)90459-5

M Merkerova, 2010, MicroRNA expression profiles in umbilical cord blood cell lineages, Stem Cells Dev, 19, 17, 10.1089/scd.2009.0071

H Liu, 2006, Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells, Mol Cancer, 16, 5

O Sripichai, 2009, Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming, Blood, 114, 2299, 10.1182/blood-2009-05-219386

A Reverter, 2008, Combining partial correlation and an information theory approach to the reversed engineering of gene co-expression networks, Bioinformatics, 24, 2491, 10.1093/bioinformatics/btn482

S Menzel, 2007, A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15, Nat Genet, 39, 1197, 10.1038/ng2108

M Uda, 2008, Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia, Proc Natl Acad Sci USA, 105, 1620, 10.1073/pnas.0711566105

EM Small, 2010, Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486, Proc Natl Acad Sci USA, 107, 4218, 10.1073/pnas.1000300107

HK Oh, 2011, Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer, Clin Cancer Res, 17, 2657, 10.1158/1078-0432.CCR-10-3152

PG Gallagher, 2000, The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter, Blood, 96, 1136, 10.1182/blood.V96.3.1136

D Zhou, 1997, Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle, J Cell Biol, 136, 621, 10.1083/jcb.136.3.621

R Navon, 2009, Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types, PLoS One, 4, e8003, 10.1371/journal.pone.0008003

J Yu, 2012, MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias, Clin Cancer Res, 18, 981, 10.1158/1078-0432.CCR-11-2347

Ali S, Saleh H, Sethi S, Sarkar FH, Philip PA (2012) MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer. Br J Cancer doi: 10.1038/bjc.2012.383.

R Hummel, 2011, Chemotherapy-induced modification of microRNA expression in esophageal cancer, Oncol Rep Rep, 26, 1011

N Mosakhani, 2012, MicroRNA profiling differentiates colorectal cancer according to KRAS status, Genes Chromosomes Cancer, 51, 1, 10.1002/gcc.20925

X Tan, 2011, A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis, Clin Cancer Res, 17, 6802, 10.1158/1078-0432.CCR-11-0419

E Chan, 2011, MicroRNA signatures differentiate melanoma subtypes, Cell Cycle, 10, 1845, 10.4161/cc.10.11.15777

H Konishi, 2011, Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma, Br J Cancer, 106, 740, 10.1038/bjc.2011.588

J Xu, 2011, Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing, Science, 334, 993, 10.1126/science.1211053

MA Hall, 2003, The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12, Proc Natl Acad Sci USA, 100, 992, 10.1073/pnas.0237324100

CM Kiefer, 2011, Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells, Blood, 118, 6200, 10.1182/blood-2011-06-363101

YF Fu, 2009, Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis, Blood, 113, 1340, 10.1182/blood-2008-08-174854