MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression

Chu, 2007, Small RNAs: regulators and guardians of the genome, J Cell Physiol, 213, 412, 10.1002/jcp.21230 Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 843, 10.1016/0092-8674(93)90529-Y Lee, 2004, MicroRNA genes are transcribed by RNA polymerase II, EMBO J, 23, 4051, 10.1038/sj.emboj.7600385 Kim, 2006, Genomics of microRNA, Trends Genet, 22, 165, 10.1016/j.tig.2006.01.003 Vatolin, 2006, A novel method to detect functional microRNA targets, J Mol Biol, 358, 983, 10.1016/j.jmb.2006.02.063 Jannot, 2008, Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans, RNA, 14, 829, 10.1261/rna.901908 Leung, 2006, Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules, Proc Natl Acad Sci USA, 103, 18125, 10.1073/pnas.0608845103 Tang, 2011, Quantitative analysis of miRNA expression in seven human foetal and adult organs, PLoS ONE, 6, e28730, 10.1371/journal.pone.0028730 Liu, 2009, Identification of miRNAs in a liver of a human fetus by a modified method, PLoS ONE, 26 Liu, 2010, Quantitative analysis of miRNA expression in several developmental stages of human livers, Hepatol Res, 40, 813, 10.1111/j.1872-034X.2010.00683.x Redova, 2012, Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma, J Transl Med, 10, 55, 10.1186/1479-5876-10-55 Bitarte, 2011, MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells, Stem Cells, 29, 1661, 10.1002/stem.741 Namløs, 2012, Modulation of the osteosarcoma expression phenotype by microRNAs, PLoS ONE, 7, e48086, 10.1371/journal.pone.0048086 Lau, 2001, An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans, Science, 294, 858, 10.1126/science.1065062 Brennecke, 2005, Principles of microRNA-target recognition, PLoS Biol, 3, e85, 10.1371/journal.pbio.0030085 Kim, 2011, miR451 and AMPK mutual antagonism in glioma cell migration and proliferation: a mathematical model, PLoS ONE, 6, e28293, 10.1371/journal.pone.0028293 Krejci, 2009, Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes, Cell Signal, 21, 151, 10.1016/j.cellsig.2008.10.006 Anglesio, 2011, IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer, Clin Cancer Res, 17, 2538, 10.1158/1078-0432.CCR-10-3314 Badache, 2001, Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells, Cancer Res, 61, 383 Lamy, 2012, Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway, Exp Cell Res, 318, 1586, 10.1016/j.yexcr.2012.04.004 Mihara, 2012, IL-6/IL-6 receptor system and its role in physiological and pathological conditions, Clin Sci, 122, 143, 10.1042/CS20110340