MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

Bartel DP . (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281–297.

Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E . (2005). Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21–24.

Bitomsky N, Bohm M, Klempnauer KH . (2004). Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene 23: 7484–7493.

Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E et al. (2002). Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukaemia. Proc Natl Acad Sci USA 99: 15524–15529.

Chan JA, Krichevsky AM, Kosik KS . (2005). MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029–6033.

Chen CZ, Li L, Lodish HF, Bartel DP . (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83–86.

Chen Y, Knosel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S et al. (2003). Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. Pathology 200: 640–646.

Cmarik J, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H et al. (1999). Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci USA 96: 14037–14042.

Croce CM, Calin GA . (2005). miRNAs, cancer, and stem cell division. Cell 122: 6–7.

Doench JG, Sharp PA . (2004). Specificity of microRNA target selection in translational repression. Genes & Dev 18: 504–511.

Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M . (2006). S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314: 467–471.

Esquela-Kerscher A, Slack FJ . (2006). Oncomirs—microRNAs with a role in cancer. Nat Rev Cancer 6: 259–269.

Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B . (2004). Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. Ann NY Acad Sci 1014: 220–222.

Hammond SM . (2006). MicroRNAs as oncogenes. Curr Opin Genet Dev 16: 4–9.

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S et al. (2005). MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065–7070.

Jansen AP, Camalier C, Colburn NH . (2005). Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res 65: 6034–6041.

Kang M, Ahn HS, Lee JY, Matsuhashi S, Park WY . (2002). Up-regulation of PDCD4 in senescent human diploid fibroblasts. Biochem Biophys Res Commun 293: 617–621.

Lankat-Buttgereit B, Gregel C, Knolle A, Hasilik A, Arnold R, Goke R . (2004). Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. Mol Cell Endocrinol 214: 149–153.

Leupold JH, Yang H-S, Colburn NH, Asangani I, Post S, Allgayer H . (2007). Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene 26: 4550–4562.

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. (2005). MicroRNA expression profiles classify human cancers. Nature 425: 834–838.

Meister G, Landthaler M, Dorsett Y, Tuschl T . (2004). Sequence-specific inhibition of microRNA and siRNA-induced RNA silencing. RNA 10: 544–550.

Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT et al. (2006). Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 130: 2113–2129.

Mudduluru G, Medved F, Grobholz R, Jost C, Gruber A, Leupold JH et al. (2007). Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer 110: 1697–1707.

Onishi Y, Hashimoto S, Kizaki H . (1998). Cloning of the TIS gene suppressed by topoisomerase inhibitors. Gene 215: 453–459.

Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y . (2005). Akt Phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res 65: 11282–11286.

Pfaffl MW . (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.

Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E et al. (2005). Inhibition of translational initiation by let-7 microRNA in human cells. Science 309: 1573–1576.

Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S et al. (2006). MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 24: 4677–4684.

Schlichter U, Burk O, Worpenberg S, Klempnauer KH . (2001). The chicken Pdcd4 gene is regulated by v-Myb. Oncogene 20: 669–676.

Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T . (1995). Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene 166: 297–301.

Si M-L, Zhu S, Wu H, Lu Z, Wu F, Mo YY . (2007). miR-21-mediated tumor growth. Oncogene 26: 2799–2803.

Yang H, Cho M, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH . (2004). A Novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Bio 24: 3894–3906.

Yang H, Knies J, Stark C, Colburn NH . (2003). Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene 22: 3712–3720.

Yang H, Matthews C, Clair T, Wang Q, Baker AR, Li CC et al. (2006). Tumorigenesis suppressor Pdcd4 downregulates MAP4K1 expression to suppress colon carcinoma cell invasion. Mol Cell Biol 26: 1297–1306.

Zakowicz H, Yang H, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH . (2005). Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA 11: 261–274.

Zamore PD, Haley B . (2005). Ribo-gnome: the big world of small RNAs. Science 309: 1519–1524.

Zhang Z, DuBois R . (2001). Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene 20: 4450–4456.

Zhu S, Si M-L, Wu H, Mo YY . (2007). MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282: 14328–14336.

Zijlstra A, Mellor R, Panzarella G, Aimes RT, Hooper JD, Marchenko ND et al. (2002). A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res 62: 7083–7092.