MicroRNA-146a and its target gene IRAK1 polymorphisms confer susceptibility to systemic lupus erythematosus

Rastin, 2017, Clinical & immunological characteristics in systemic lupus erythematosus patients, Indian J Med Res, 146, 224, 10.4103/ijmr.IJMR_1356_15 Rekvig, 2018, Systemic lupus erythematosus: definitions, contexts, conflicts, enigmas, Front Immunol, 9, 10.3389/fimmu.2018.00387 Zhang, 2011, Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus, Mol Biol Rep, 38, 1463, 10.1007/s11033-010-0252-6 O’Brien, 2018, Overview of microRNA biogenesis, mechanisms of actions, and circulation, Front Endocrinol, 9, 402, 10.3389/fendo.2018.00402 Jiménez-Morales, 2012, MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients, Tissue Antigens, 80, 317, 10.1111/j.1399-0039.2012.01929.x Kaarthikeyan, 2020, Association analysis of miR-499 rs3746444 gene polymorphism with periodontitis, Int J Immunogenet, 47, 485, 10.1111/iji.12508 Testa, 2017, miR-146 and miR-155: two key modulators of immune response and tumor development, Noncod RNA, 3, 22 Lee, 2016, MiR-146 and miR-125 in the regulation of innate immunity and inflammation, BMB Rep, 49, 311, 10.5483/BMBRep.2016.49.6.056 Ramkaran, 2014, miR-146a polymorphism influences levels of miR-146a IRAK-1, and TRAF-6 in young patients with coronary artery disease, Cell Biochem Biophys, 68, 259, 10.1007/s12013-013-9704-7 Elessawi, 2020, Micro RNA 499 gene expression and interleukin 17 in Egyptian patients with Behçet's disease, Egypt Rheumatol, 42, 135, 10.1016/j.ejr.2019.07.003 Mai, 2012, MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors, Front Biosci (Elite Ed), 4, 1478, 10.2741/e474 Alemán-Ávila, 2017, Functional polymorphisms in pre-miR146a and pre-miR499 are associated with systemic lupus erythematosus but not with rheumatoid arthritis or Graves’ disease in Mexican patients, Oncotarget, 8, 91876, 10.18632/oncotarget.19621 Zhang, 2017, Effects of microRNA-499 on the inflammatory damage of endothelial cells during coronary artery disease via the targeting of PDCD4 through the NF-Kβ/TNF-α signaling pathway, Cell Physiol Biochem, 44, 110, 10.1159/000484588 Shaker, 2018, Association of MiRNA-146a, MiRNA-499 IRAK1 and PADI4 polymorphisms with rheumatoid arthritis in Egyptian population, Cell Physiol Biochem, 46, 2239, 10.1159/000489592 Ahmadi, 2020, Polymorphisms of pre-miR-499 rs3746444 T/C and pre-miR-146a rs2910164C/G in the autoimmune diseases of rheumatoid arthritis and systemic lupus erythematosus in the west of Iran, Iran J Public Health, 49, 782 Löfgren, 2012, Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene, Genes Immun, 13, 268, 10.1038/gene.2011.84 Ulhaq, 2020, Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia, Med Clin (Barc), 10.1016/j.medcli.2020.07.002 Ulhaq, 2020, Aqueous humor interleukin-6 levels in primary open-angle glaucoma (POAG): a systematic review and meta-analysis, Arch Soc Esp Oftalmol (Engl Ed), 95, 315, 10.1016/j.oftal.2020.03.018 Ulhaq, 2020, Chemokine IL-8 level in aqueous humor of open-angle glaucoma: a meta-analysis, Arch Soc Esp Oftalmol (Engl Ed), 95, 114, 10.1016/j.oftal.2019.11.014 Ulhaq, 2020, Comment on the assessment of “Association of interleukin-6 gene polymorphisms and glaucoma: systematic review and meta-analysis”, Eur J Ophthalmol Soraya, 2020, Crucial laboratory parameters in COVID-19 diagnosis and prognosis: an updated meta-analysis, Med Clin (Barc), 155, 143, 10.1016/j.medcli.2020.05.017 Ulhaq, 2020, Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia, Acta Neurol Belg Ulhaq, 2020, Genetic polymorphisms associated with age-related macular degeneration, Int J Retina, 3, 10.35479/ijretina.2020.vol003.iss001.102 Ulhaq, 2020, Inflammation-related gene polymorphisms associated with Parkinson's disease: an updated meta-analysis, Egypt J Med Hum Genet, 21, 14, 10.1186/s43042-020-00056-6 Ulhaq, 2020, Interleukin-6 as a potential biomarker of COVID-19 progression, Med Mal Infect, 50, 382, 10.1016/j.medmal.2020.04.002 Soraya, 2020, Interleukin-6 levels in children developing SARS-CoV-2 infection, Pediatr Neonatol, 61, 253, 10.1016/j.pedneo.2020.04.007 Ulhaq, 2020, [Recurrent positive SARS-CoV-2 RNA tests in recovered and discharged patients], Rev Clin Esp, 220, 524, 10.1016/j.rce.2020.06.012 Ulhaq, 2021, Roles of IL-8-251A/T and +781C/T polymorphisms IL-8 level, and the risk of age-related macular degeneration, Arch Soc Esp Oftalmol (Engl Ed), 10.1016/j.oftal.2020.02.019 Ulhaq, 2020, The association between genetic polymorphisms in estrogen receptor genes and the risk of ocular disease: a meta-analysis, Turk J Ophthalmol, 50, 216, 10.4274/tjo.galenos.2020.91298 Ulhaq, 2020, The association of estrogen-signaling pathways and susceptibility to open-angle glaucoma, Beni-Suef Univ J Basic Appl Sci, 9, 10.1186/s43088-020-0034-8 Ulhaq, 2020, The prevalence of ophthalmic manifestations in COVID-19 and the diagnostic value of ocular tissue/fluid, Graefes Arch Clin Exp Ophthalmol, 258, 1351, 10.1007/s00417-020-04695-8 Ulhaq, 2020, The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis, Sci Rep, 10, 17453, 10.1038/s41598-020-74203-9 Ulhaq, 2020, Update on “Associations of estrogen receptor alpha gene polymorphisms with type 2 diabetes mellitus and metabolic syndrome: a systematic review and meta-analysis”, Horm Metab Res, 52, 67, 10.1055/a-1063-6377 Ulhaq, 2020, Vitamin D and its receptor polymorphisms are associated with glaucoma, J Fr Ophtalmol, 43, 1009, 10.1016/j.jfo.2020.02.016 Labib, 2019, Association between miRNA-146a and polymorphisms of its target gene IRAK1, regarding susceptibility to and clinical features of systemic lupus erythematous and multiple sclerosis, Lab Med, 50, 34, 10.1093/labmed/lmy033 Zhai, 2013, Association of interleukin-1 receptor-associated kinase (IRAK1) gene polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus in a Chinese Han population, Inflamm Res, 62, 555, 10.1007/s00011-013-0607-2 Fouda, 2020, Genetic variants of microRNA-146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, and disease activity, Mol Biol Rep, 47, 7459, 10.1007/s11033-020-05802-y Chen, 2013, Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: a meta-analysis, Gene, 521, 259, 10.1016/j.gene.2013.03.073 Fu, 2016, Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility, Hum Immunol, 77, 1, 10.1016/j.humimm.2014.09.002 Ji, 2014, Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis, Lupus, 23, 1023, 10.1177/0961203314534512 Lee, 2015, The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis, Z Rheumatol, 74, 153, 10.1007/s00393-014-1509-6 Sun, 2017, Relationship of miRNA-146a to primary Sjögren's syndrome and to systemic lupus erythematosus: a meta-analysis, Rheumatol Int, 37, 1311, 10.1007/s00296-017-3756-8 Luo, 2011, A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus, PLoS Genet, 7, e1002128, 10.1371/journal.pgen.1002128 Saba, 2014, MicroRNA-146a: a dominant, negative regulator of the innate immune response, Front Immunol, 5, 10.3389/fimmu.2014.00578 Perez-Hernandez, 2020, Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis, J Nephrol Wang, 2017, Two single nucleotide polymorphisms (rs2431697 and rs2910164) of miR-146a are associated with risk of coronary artery disease, Int J Environ Res Public Health, 14, 514, 10.3390/ijerph14050514 Chatzikyriakidou, 2019, Association of IRAK1 gene polymorphism rs3027898 with papillary cancer restricted to the thyroid gland: a pilot study, In Vivo, 33, 2281, 10.21873/invivo.11734 Zhou, 2018, Upregulated IL-1 receptor-associated kinase 1 (IRAK1) in systemic lupus erythematosus: IRAK1 inhibition represses Th17 differentiation with therapeutic potential, Immunol Invest, 47, 468, 10.1080/08820139.2018.1458105 Lu, 2014, MicroRNA-499 rs3746444 polymorphism and autoimmune diseases risk: a meta-analysis, Mol Diagn Ther, 18, 237, 10.1007/s40291-013-0073-0