MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

Almind, 2007, Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice, Proc. Natl. Acad. Sci. USA, 104, 2366, 10.1073/pnas.0610416104 Atit, 2006, Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse, Dev. Biol., 296, 164, 10.1016/j.ydbio.2006.04.449 Bosnakovski, 2008, Prospective isolation of skeletal muscle stem cells with a Pax7 reporter, Stem Cells, 26, 3194, 10.1634/stemcells.2007-1017 Bowman, 1969, Actions of sympathomimetic amines and their antagonists on skeletal muscle, Pharmacol. Rev., 21, 27 Cannon, 2001, Respiratory and thermogenic capacities of cells and mitochondria from brown and white adipose tissue, Methods Mol. Biol., 155, 295 Cannon, 2004, Brown adipose tissue: function and physiological significance, Physiol. Rev., 84, 277, 10.1152/physrev.00015.2003 Chance, 1955, A simple and rapid assay of oxidative phosphorylation, Nature, 175, 1120, 10.1038/1751120a0 Chargé, 2004, Cellular and molecular regulation of muscle regeneration, Physiol. Rev., 84, 209, 10.1152/physrev.00019.2003 Chen, 2006, The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation, Nat. Genet., 38, 228, 10.1038/ng1725 Cypess, 2010, Brown fat as a therapy for obesity and diabetes, Curr. Opin. Endocrinol. Diabetes Obes., 17, 143, 10.1097/MED.0b013e328337a81f Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N. Engl. J. Med., 360, 1509, 10.1056/NEJMoa0810780 Frontini, 2010, Distribution and development of brown adipocytes in the murine and human adipose organ, Cell Metab., 11, 253, 10.1016/j.cmet.2010.03.004 Ghorbani, 1997, Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats, Int. J. Obes. Relat. Metab. Disord., 21, 465, 10.1038/sj.ijo.0800432 Houten, 2010, A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation, J. Inherit. Metab. Dis., 33, 469, 10.1007/s10545-010-9061-2 Joe, 2010, Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis, Nat. Cell Biol., 12, 153, 10.1038/ncb2015 Kajimura, 2008, Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex, Genes Dev., 22, 1397, 10.1101/gad.1666108 Kalaany, 2005, LXRs regulate the balance between fat storage and oxidation, Cell Metab., 1, 231, 10.1016/j.cmet.2005.03.001 Kopecky, 1995, Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity, J. Clin. Invest., 96, 2914, 10.1172/JCI118363 Krief, 1993, Tissue distribution of beta 3-adrenergic receptor mRNA in man, J. Clin. Invest., 91, 344, 10.1172/JCI116191 Krützfeldt, 2005, Silencing of microRNAs in vivo with ‘antagomirs’, Nature, 438, 685, 10.1038/nature04303 Kuang, 2007, Asymmetric self-renewal and commitment of satellite stem cells in muscle, Cell, 129, 999, 10.1016/j.cell.2007.03.044 Larsen, 2012, Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects, J. Physiol., 590, 3349, 10.1113/jphysiol.2012.230185 Lepper, 2010, Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells, Genesis, 48, 424, 10.1002/dvg.20630 Matthias, 2000, Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis, J. Biol. Chem., 275, 25073, 10.1074/jbc.M000547200 Nedergaard, 2007, Unexpected evidence for active brown adipose tissue in adult humans, Am. J. Physiol. Endocrinol. Metab., 293, E444, 10.1152/ajpendo.00691.2006 Nedergaard, 2010, Three years with adult human brown adipose tissue, Ann. N Y Acad. Sci., 1212, E20, 10.1111/j.1749-6632.2010.05905.x Nishijo, 2009, Biomarker system for studying muscle, stem cells, and cancer in vivo, FASEB J., 23, 2681, 10.1096/fj.08-128116 Ouellet, 2012, Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans, J. Clin. Invest., 122, 545, 10.1172/JCI60433 Pfannenberg, 2010, Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans, Diabetes, 59, 1789, 10.2337/db10-0004 Saito, 2009, High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity, Diabetes, 58, 1526, 10.2337/db09-0530 Scimè, 2005, Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha, Cell Metab., 2, 283, 10.1016/j.cmet.2005.10.002 Seale, 2000, Pax7 is required for the specification of myogenic satellite cells, Cell, 102, 777, 10.1016/S0092-8674(00)00066-0 Seale, 2007, Transcriptional control of brown fat determination by PRDM16, Cell Metab., 6, 38, 10.1016/j.cmet.2007.06.001 Seale, 2008, PRDM16 controls a brown fat/skeletal muscle switch, Nature, 454, 961, 10.1038/nature07182 Seale, 2011, Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice, J. Clin. Invest., 121, 96, 10.1172/JCI44271 Trajkovski, 2012, MyomiR-133 regulates brown fat differentiation through Prdm16, Nat. Cell Biol., 14, 1330, 10.1038/ncb2612 van Marken Lichtenbelt, 2009, Cold-activated brown adipose tissue in healthy men, N. Engl. J. Med., 360, 1500, 10.1056/NEJMoa0808718 Virtanen, 2009, Functional brown adipose tissue in healthy adults, N. Engl. J. Med., 360, 1518, 10.1056/NEJMoa0808949 Walden, 2009, Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes, J. Cell. Physiol., 218, 444, 10.1002/jcp.21621 Wang, 2012, Satellite cells, the engines of muscle repair, Nat. Rev. Mol. Cell Biol., 13, 127, 10.1038/nrm3265 Williams, 2009, MicroRNA control of muscle development and disease, Curr. Opin. Cell Biol., 21, 461, 10.1016/j.ceb.2009.01.029 Zingaretti, 2009, The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue, FASEB J., 23, 3113, 10.1096/fj.09-133546