Chuột không có các Ganglioside chính trong não phát triển triệu chứng Parkinson

Allende ML, Proia RL (2002) Lubricating cell signaling pathways with gangliosides. Current Opinion in Struct Biol 12:587–592 Takamiya K, Yamamoto A, Furukawa K et al (1996) Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc Nat Acad Sc USA 93:10662–10667 Sheikh KA, Sun J, Liu Y et al (1999) Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Nat Acad Sci USA 96:7532–7537 Chiavegatto S, Sun J, Nelson RJ et al (2000) A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. Exp Neurol 166:227–234 Wu G, Xie X, Lu Z-H et al (2001) Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium. Proc Natl Acad Sci USA 98:307–312 Wu G, Lu Z-H, Wang J et al (2005) Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci 25:11014–11022 Braak H, Del Tredici K, Rub U et al (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24:197–211 Meredith GE, Sonsalla PK, Chesselet M-F (2008) Animal models of Parkinson’s disease progression. Acta Neuropathol 115:385–398 Hadjiconstantinou M, Rossetti ZL, Paxton RC et al (1986) Administration of GM1 ganglioside restores the dopamine content in striatum after chronic treatment with MPTP. Neuropharm 25:1075–1077 Schneider JS, Kean A, DiStefano L (1995) GM1 ganglioside rescues substantia nigra pars compacta neurons and increases DA synthesis in residual nigrostriatal dopaminergic neurons in MPTP-treated mice. J Neurosci Res 42:117–123 Schneider JS, DiStefano L (1995) Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. Neuropharm 34:489–493 Hadjiconstantinou M, Mariani AP, Neff NH (1989) GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study. Brain Res 484:297–303 Pope-Coleman A, Schneider JS (1998) Effects of chronic GM1 ganglioside treatment on cognitive and motor deficits in a slowly progressing model of Parkinsonism in non-human primates. Restorative Neurol Neurosci 12:255–266 Schneider JS, Roeltgen DP, Mancall EL (1998) Parkinson’s disease: improved function with GM1 ganglioside treatment in a randomized placebo-controlled study. Neurology 50:1630–1636 Schneider JS, Sendek S, Daskalakis C et al (2010) GM1 ganglioside in Parkinson’s disease: results of a five year open study. J Neurol Sciences 292:45–51 Liu Y, Wada R, Kawai H et al (1999) A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest 103:497–505 Sedelis M, Hofele K, Auburger GW et al (2000) MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences. Behav Genet 30:171–182 Lu XH, Fleming SM, Meurers B et al (2009) Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci 29:1962–1976 Prasad K, Richfield EK (2008) Sporadic midbrain dopamine neuron abnormalities in laboratory mice. Neurobiol Disease 32:262–272 Prasad K, Richfield EK (2010) Number and nuclear morphology of TH+ and TH− neurons in the mouse ventral midbrain using epifluorescence stereology. Exp Neurol 225:328–340 Lees M, Paxman S (1972) Lipid composition of the normal human brain: gray matter, white matter, and myelin. J Lipid Res 6:537–544 German DC, Manaye KF, Sonsalla PK, Brooks BA (1992) Midbrain dopaminergic cell loss in Parkinson’s disease and MPTP-induced Parkinsonism: sparing of calbindin-D28k-containing cells. Ann NY Acad Sci 648:42–62 Fahn S (2006) Description of Parkinson’s disease as a clinical syndrome. Ann NY Acad Sci 991:1–14 Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psych 79:368–376 Eriksen JL, Dawson TM, Dickson DW et al (2003) Caught in the act: alpha-synuclein is the culprit in Parkinson’s disease. Neuron 40:453–456 Matsuda J, Vanier MT, Popa J et al (2006) GD3- and O-acetylated GD3-gangliosides in the GM2 synthase-deficient mouse brain and their immunohistochemical localization. Proc Jpn Acad Ser B 82:189–196 Manev H, Favaron M, Vicini S et al (1990) Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids. J Pharmacol Exp Ther 252:419–427 Wu G, Lu Z-H, Xie X et al (2004) Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J 21:305–313 Schneider JS, DiStefano L (1994) Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism. Neurology 44:748–750 Xie X, Wu G, Lu Z-H et al (2002) Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside. J Neurochem 81:1185–1195 Wu G, Xie X, Lu Z-H et al (2009) Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum. Proc Natl Acad Sci USA 106:10829–10834 Wei J, Fujita M, Nakai M et al (2009) Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Amer J Pathol 174:1891–1909 Martinez Z, Zhu M, Han S et al (2007) GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. Biochemistry 46:1868–1877 Chan CS, Gertler TS, Surmeier DJ (2009) Calcium homeostasis, selective vulnerability and Parkinson’s disease. Trends Neurosci 32:249–256 Okada M, Itoh M, Haraguchi M et al (2002) b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem 277:1633–1636 Handa Y, Ozaki N, Honda T et al (2005) GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation. Pain 117:271–279 Miyagi T, Wada T, Iwamatsu A et al (1999) Molecular cloning and characterization of plasma membrane-associated sialidase specific for gangliosides. J Biol Chem 274:5004–5011 Wang J, Wu G, Miyagi T, Lu Z-H, Ledeen RW (2009) Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a. J Neurochem 111:547–554 Goodwin NS, Engelborghs Y, Pountney DL (2010) Raised calcium promotes α-synuclein aggregate formation. Mol Cell Neurosci (2010 Dec 8) [Epub ahead of print] Yazdani U, German DC, Liang C-L et al (2006) Rat model of Parkinson’s disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+). Exp Neurol 200:172–183