Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Neuron - Tập 25 Số 1 - Trang 239-252 - 2000
Asa Abeliovich1, Yvonne Schmitz2, Isabel Fariñas3, DL Choi-Lundberg4, Wei-Hsien Ho4, Dominick P. Purpura5, Natasha Shinsky4, José Manuel García‐Verdugo3, Mark Armanini4, Anne Ryan4, M. Hynes4, Heidi Phillips4, David Sulzer2, Arnon Rosenthal4
1Department of Neurology University of California, San Francisco San Francisco, California 94143, USA
2Departments of Neurology and Psychiatry, Columbia University, New York State Psychiatric Institute, Department of Neuroscience, New York, New York 10032, USA
3Department Biología Celular, Universidad de Valencia, 46100 Burjasot, Spain
4Department of Neuroscience, Genentech, South San Francisco, California 94080, USA
5Nancy Friend Pritzker Laboratory, Departments of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Buchman, 1998, Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system, J. Neurosci., 18, 9335, 10.1523/JNEUROSCI.18-22-09335.1998

Castillo, 1997, Rab3A is essential for mossy fibre long-term potentiation in the hippocampus, Nature, 388, 590, 10.1038/41574

Clayton, 1998, The synucleins, Trends Neurosci., 21, 249, 10.1016/S0166-2236(97)01213-7

Cohen, 1998, Pathologic conformations of prion proteins, Annu. Rev. Biochem., 67, 793, 10.1146/annurev.biochem.67.1.793

Conway, 1998, Accelerated in vitro fibril formation by a mutant linked to early-onset Parkinson's disease, Nat. Med., 4, 1318, 10.1038/3311

Davidson, 1998, Stabilization of α-synuclein secondary structure upon binding to synthetic membranes, J. Biol. Chem., 273, 9443, 10.1074/jbc.273.16.9443

DiFiglia, 1997, Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990

Dittman, 1998, Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse, J. Neurosci., 18, 6147, 10.1523/JNEUROSCI.18-16-06147.1998

Fon, 1997, Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action, Neuron, 19, 1271, 10.1016/S0896-6273(00)80418-3

Frohman, 1996, Phospholipid signaling, Curr. Biol., 6, 945, 10.1016/S0960-9822(02)00634-6

Garris, 1994, Heterogeneity of evoked dopamine overflow in striatal and striatoamygdaloid regions, Neuroscience, 59, 417, 10.1016/0306-4522(94)90606-8

Garris, 1999, Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation, Nature, 398, 67, 10.1038/18019

George, 1995, Characterization of a novel protein regulated during the critical period for song learning in the zebra finch, Neuron, 15, 361, 10.1016/0896-6273(95)90040-3

Goda, 1997, Calcium regulation of neurotransmitter release, Curr. Opin. Cell Biol., 9, 513, 10.1016/S0955-0674(97)80027-0

Gomis, 1999, Two actions of calcium regulate the supply of releasable vesicles at the ribbon synapse of retinal bipolar cells, J. Neurosci., 19, 6309, 10.1523/JNEUROSCI.19-15-06309.1999

Grace, 1984, The control of firing pattern in nigral dopamine neurons, J. Neurosci., 4, 2877, 10.1523/JNEUROSCI.04-11-02877.1984

Hong, 1998, Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17, Science, 282, 1914, 10.1126/science.282.5395.1914

Horger, 1998, Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons, J. Neurosci., 18, 4929, 10.1523/JNEUROSCI.18-13-04929.1998

Hynes, 1995, Control of neuronal diversity by the floor plate, Cell, 80, 95, 10.1016/0092-8674(95)90454-9

Iwai, 1995, The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system, Neuron, 14, 467, 10.1016/0896-6273(95)90302-X

Jakes, 1994, Identification of 2 distinct synucleins from human brain, FEBS Lett., 345, 27, 10.1016/0014-5793(94)00395-5

Jenco, 1998, Regulation of phospholipase D2, Biochemistry, 37, 4901, 10.1021/bi972776r

Jensen, 1995, Residues in the synuclein consensus motif of α-synuclein fragment, NAC, participate in the transglutaminase-catalysed cross-linking to Alzheimer-disease amyloid βA4 peptide, Biochem. J., 310, 91, 10.1042/bj3100091

Jensen, 1997, Binding of Aβ to α- and β-synucleins, Biochem. J., 323, 539, 10.1042/bj3230539

Jones, 1998, Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter, J. Neurosci., 18, 1979, 10.1523/JNEUROSCI.18-06-01979.1998

Kennedy, 1992, Dynamic observations of dopamine autoreceptor effects in rat striatal slices, J. Neurochem., 59, 449, 10.1111/j.1471-4159.1992.tb09391.x

Klein, 1995, Role of phospholipase D activation in nervous system physiology and pathophysiology, J. Neurochem., 65, 1445, 10.1046/j.1471-4159.1995.65041445.x

Krüger, 1998, Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease, Nat. Genet., 18, 106, 10.1038/ng0298-106

Lavedan, 1998, The synuclein family, Genome Res., 8, 871, 10.1101/gr.8.9.871

Maroteaux, 1991, The rat brain synucleins; family of proteins transiently associated with neuronal membrane, Brain Res. Mol. Brain Res., 11, 335, 10.1016/0169-328X(91)90043-W

Maroteaux, 1988, Synuclein, J. Neurosci., 8, 2804, 10.1523/JNEUROSCI.08-08-02804.1988

Mezey, 1998, α-synuclein in neurodegenerative disorders, Nat. Med., 4, 755, 10.1038/nm0798-755

Moore, 1996, Renal and neuronal abnormalities in mice lacking GDNF, Nature, 382, 76, 10.1038/382076a0

Ostrerova, 1999, α-Synuclein shares physical and functional homology with 14-3-3 protein, J. Neurosci., 19, 5782, 10.1523/JNEUROSCI.19-14-05782.1999

Paik, 1998, Self-oligomerization of NACP, the precursor protein of the non-amyloid β-/A4 (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25–35), FEBS Lett., 421, 73, 10.1016/S0014-5793(97)01537-8

Polymeropoulos, 1997, Mutations in the α-synuclein gene identified in families with Parkinson's disease, Science, 276, 2045, 10.1126/science.276.5321.2045

Rebec, 1997, Transient increases in catecholamine activity in medial prefrontal cortex and nucleus accumbens shell during novelty, Neuroscience, 76, 707, 10.1016/S0306-4522(96)00382-X

Schlüter, 1999, Rabphilin knock-out mice reveal that rabphilin is not required for Rab3 function in regulating neurotransmitter release, J. Neurosci., 19, 5834, 10.1523/JNEUROSCI.19-14-05834.1999

Seiden, 1993, Amphetamine, Annu. Rev. Pharmacol. Toxicol., 32, 639, 10.1146/annurev.pa.33.040193.003231

Spillantini, 1998, α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies, Proc. Natl. Acad. Sci. USA, 95, 6469, 10.1073/pnas.95.11.6469

Starke, 1989, Modulation of presynaptic release by presynaptic autoreceptors, J. Neurochem., 2, 449

Stevens, 1995, Estimates for the pool size of releasable quanta at a single central synapse and for the time required to fill the pool, Proc. Natl. Acad. Sci. USA, 92, 846, 10.1073/pnas.92.3.846

Stevens, 1998, Activity-dependent modulation of the rat at which synaptic vesicles become available to undergo exocytosis, Neuron, 21, 415, 10.1016/S0896-6273(00)80550-4

Südhof, 1995, The synaptic vesicle cycle, Nature, 375, 645, 10.1038/375645a0

Sulzer, 1995, Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport, J. Neurosci., 15, 4102, 10.1523/JNEUROSCI.15-05-04102.1995

Tong, 1996, Long-term potentiation in cultures of single hippocampal granule cells, Neuron, 16, 1147, 10.1016/S0896-6273(00)80141-5

Ueda, 1993, Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 90, 11282, 10.1073/pnas.90.23.11282

Wang, 1998, High-frequency firing helps replenish the readily releasable pool of synaptic vesicles, Nature, 394, 384, 10.1038/28645

Weinreb, 1996, NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded, Biochemistry, 35, 13709, 10.1021/bi961799n

Wightman, 1990, Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake, Brain Res. Brain Res. Rev., 15, 135, 10.1016/0165-0173(90)90015-G

Williams, 1995, Modulation of memory fields by dopamine D1 receptors in prefrontal cortex, Nature, 376, 572, 10.1038/376572a0

Wise, 1996, Addictive drugs and brain stimulation reward, Annu. Rev. Neurosci., 19, 319, 10.1146/annurev.ne.19.030196.001535