MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Engineering - Tập 16 - Trang 162-175 - 2022
Tao Rui1, Xueyou Zhang2,3, Shi Feng2,3, Haitao Huang2,3, Shaowei Zhan2,3, Haiyang Xie2,3, Lin Zhou2,3, Shusen Zheng2,3, Qi Ling2,3
1Department of Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2Department of Surgery, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
3Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province, Hangzhou, 310003, China

Tài liệu tham khảo

Siegel, 2018, Cancer statistics, 2018, CA Cancer J Clin, 68, 7, 10.3322/caac.21442 Cronin, 2018, Annual report to the nation on the status of cancer, part I: national cancer statistics, Cancer, 124, 2785, 10.1002/cncr.31551 Ryder, 2003, Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults, Gut, 52, iii1, 10.1136/gut.52.suppl_3.iii1 Bruix, 2017, Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial, Lancet, 389, 56, 10.1016/S0140-6736(16)32453-9 Livraghi, 2008, Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?, Hepatology, 47, 82, 10.1002/hep.21933 Bruix, 2004, Chemoembolization for hepatocellular carcinoma, Gastroenterology, 127, S179, 10.1053/j.gastro.2004.09.032 Sapisochin, 2017, Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches, Nat Rev Gastroenterol Hepatol, 14, 203, 10.1038/nrgastro.2016.193 Berindan-Neagoe, 2014, MicroRNAome genome: a treasure for cancer diagnosis and therapy, CA Cancer J Clin, 64, 311, 10.3322/caac.21244 Wang, 2016, microRNAs in the same clusters evolve to coordinately regulate functionally related genes, Mol Biol Evol, 33, 2232, 10.1093/molbev/msw089 Kabekkodu, 2018, Clustered miRNAs and their role in biological functions and diseases, Biol Rev, 93, 1955, 10.1111/brv.12428 Gennarino, 2012, Identification of microRNA-regulated gene networks by expression analysis of target genes, Genome Res, 22, 1163, 10.1101/gr.130435.111 Pagliuca, 2013, Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression, Oncogene, 32, 4806, 10.1038/onc.2012.495 Noguer-Dance, 2010, The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta, Hum Mol Genet, 19, 3566, 10.1093/hmg/ddq272 Rui, 2020, The chromosome 19 microRNA cluster, regulated by promoter hypomethylation, is associated with tumour burden and poor prognosis in patients with hepatocellular carcinoma, J Cell Physiol, 235, 6103, 10.1002/jcp.29538 Augello, 2012, MicroRNA profiling of hepatocarcinogenesis identifies C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma, Liver Int, 32, 772, 10.1111/j.1478-3231.2012.02795.x Fornari, 2012, In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2, J Pathol, 227, 275, 10.1002/path.3995 Toffanin, 2011, MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a, Gastroenterology, 140, 1618, 10.1053/j.gastro.2011.02.009 Mills, 2019, Cancer-derived extracellular vesicle-associated microRNAs in intercellular communication: one cell’s trash is another cell’s treasure, Int J Mol Sci, 20, 6109, 10.3390/ijms20246109 Colombo, 2014, Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles, Annu Rev Cell Dev Biol, 30, 255, 10.1146/annurev-cellbio-101512-122326 Delorme-Axford, 2013, Autophagy as a mechanism of antiviral defense at the maternal-fetal interface, Autophagy, 9, 2173, 10.4161/auto.26558 Delorme-Axford, 2013, Human placental trophoblasts confer viral resistance to recipient cells, Proc Natl Acad Sci USA, 110, 12048, 10.1073/pnas.1304718110 Bullerdiek, 2012, Exosome-delivered microRNAs of “chromosome 19 microRNA cluster” as immunomodulators in pregnancy and tumorigenesis, Mol Cytogenet, 5, 27, 10.1186/1755-8166-5-27 Zhang, 2020, TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding, Aging, 12, 13365, 10.18632/aging.103442 Chong, 2018, MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis, Nucleic Acids Res, 46, W486, 10.1093/nar/gky310 Singh, 2019, DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays, Bioinformatics, 35, 3055, 10.1093/bioinformatics/bty1054 Karnovsky, 2012, Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data, Bioinformatics, 28, 373, 10.1093/bioinformatics/btr661 Rui, 2020, The similar effects of miR-512-3p and miR-519a-2-5p on the promotion of hepatocellular carcinoma: different tunes sung with equal skill, Front Oncol, 10, 1244, 10.3389/fonc.2020.01244 Meunier, 2013, Birth and expression evolution of mammalian microRNA genes, Genome Res, 23, 34, 10.1101/gr.140269.112 Heusermann, 2016, Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER, J Cell Biol, 213, 173, 10.1083/jcb.201506084 Tian, 2010, Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy, J Cell Biochem, 111, 488, 10.1002/jcb.22733 Tseng, 2013, LMBD1 protein serves as a specific adaptor for insulin receptor internalization, J Biol Chem, 288, 32424, 10.1074/jbc.M113.479527 Shi, 2019, Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure, Stress, 22, 366, 10.1080/10253890.2019.1568987 Orlicky, 1998, Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells, J Lipid Res, 39, 1152, 10.1016/S0022-2275(20)32539-6 Scott, 2017, Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism, Nucleic Acids Res, 45, 12509, 10.1093/nar/gkx963 Liu, 2017, A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis, Hepatology, 66, 167, 10.1002/hep.29183 Vander Heiden, 2017, Understanding the intersections between metabolism and cancer biology, Cell, 168, 657, 10.1016/j.cell.2016.12.039 Villa, 2019, Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides, Cancers, 11, 688, 10.3390/cancers11050688 Yin, 2018, Potential mechanisms connecting purine metabolism and cancer therapy, Front Immunol, 9, 1697, 10.3389/fimmu.2018.01697 Ma, 2019, Dual-specificity tyrosine phosphorylation-regulated kinase 3 loss activates purine metabolism and promotes hepatocellular carcinoma progression, Hepatology, 70, 1785, 10.1002/hep.30703 Santana-Codina, 2018, Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis, Nat Commun, 9, 4945, 10.1038/s41467-018-07472-8 Feng, 2020, UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism, Embo J, 39, 10.15252/embj.2019102541 Newman, 2017, One-carbon metabolism in cancer, Br J Cancer, 116, 1499, 10.1038/bjc.2017.118 Ribbenstedt, 2018, Development, characterization and comparisons of targeted and non-targeted metabolomics methods, PLoS ONE, 13, e0207082, 10.1371/journal.pone.0207082 Piazza, 2018, A map of protein-metabolite interactions reveals principles of chemical communication, Cell, 172, 358, 10.1016/j.cell.2017.12.006