MiR-146a/b: a family with shared seeds and different roots

Physiological Genomics - Tập 49 Số 4 - Trang 243-252 - 2017
Mark Paterson1, Alison J. Kriegel2,1
1Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; and
2Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

Tóm tắt

MicroRNAs are small, noncoding, RNAs known for their powerful modulation of molecular processes, making them a major focus for studying pathological mechanisms. The human miR-146 family of microRNAs consists of two member genes, MIR146A and MIR146B. These two microRNAs are located on different chromosomes and exhibit differential regulation in many cases. However, they are nearly identical in sequence, sharing a seed region, and are thus predicted to target the same set of genes. A large proportion of the microRNA (miR)-146 literature focuses on its role in regulating the innate immune response in the context of various pathologies by modulating two widely studied target genes in the toll-like receptor signaling cascade. A growing subset of the literature reports a role of miR-146 in cardiovascular and renal disease, and data suggest there is exciting potential for miR-146 as a diagnostic and therapeutic target. Nevertheless, the published literature is confounded by unclear and imprecise language concerning the specific effects of the two miR-146 family members. The present review will compare the genomic origin and regulation of miR-146a and miR-146b, discuss some approaches to overcome analytical and experimental challenges, and summarize findings in major areas of miR-146 research. Moving forward, careful evaluation of miR-146a/b specificity in analytical and experimental approaches will aid researchers in elucidating the functional relevance of differential regulation of the miR-146 family members in health and disease.

Từ khóa


Tài liệu tham khảo

10.7554/eLife.05005

10.1038/nri1391

10.1093/nar/gkq167

10.1038/4641227a

10.1016/j.cell.2009.01.002

10.1152/physrev.00041.2015

10.1152/ajprenal.00387.2015

10.1038/onc.2008.171

10.18632/aging.100042

10.1182/blood-2010-04-273771

10.1002/bies.201300104

10.1073/pnas.0408192102

10.1016/j.cell.2009.01.035

10.1038/srep22312

10.1038/ng.2007.30

10.1016/j.chom.2010.09.005

10.1093/nar/gkr604

10.3389/fgene.2014.00337

10.1084/jem.20061692

10.1161/CIRCRESAHA.115.305242

10.1073/pnas.1219852110

10.1093/nar/gkl183

10.1007/978-1-4939-6730-8_11

10.1093/cvr/cvv120

10.1038/nature06783

10.1093/nar/gki193

10.1101/gr.082701.108

10.4049/jimmunol.1403155

10.1093/nar/gkj112

10.1172/JCI64365

10.1093/cvr/cvq274

10.1038/nrg3765

10.1038/nrg1379

10.1038/nature05939

10.1007/s10753-016-0492-2

10.4049/jimmunol.0900707

10.1016/j.yjmcc.2014.06.018

10.1158/0008-5472.CAN-08-3559

10.1073/pnas.0802682105

10.1038/ncomms12864

10.1161/HYPERTENSIONAHA.115.05645

10.1093/nar/gkq718

10.1152/physiolgenomics.00173.2011

10.1152/physiolgenomics.00141.2011

10.1042/CS20110159

10.1038/nrg2843

10.1093/nar/gkm024

10.1038/nature04303

10.1038/sj.cdd.4402310

Kutty RK, 2013, Mol Vis, 19, 737

10.1016/S0960-9822(02)00809-6

10.1186/s12014-016-9124-y

10.1016/j.bbrc.2014.02.096

10.3892/mmr.2015.4333

10.1161/CIRCRESAHA.117.305844

10.1016/j.neulet.2010.09.079

10.1038/nrd4359

10.1152/physiolgenomics.00080.2009

10.1152/ajprenal.00045.2009

10.1158/0008-5472.CAN-14-2108

10.1159/000437090

10.1161/HYPERTENSIONAHA.109.144428

10.1038/nrneph.2011.26

10.1182/blood-2016-05-714535

10.1074/jbc.M805371200

10.1093/jmcb/mjr007

10.4137/CIN.S30563

10.1038/sj.leu.2402713

10.1097/FJC.0b013e3181f603d0

10.2147/IJN.S82587

10.1002/emmm.201201749

10.1038/nrg3162

10.1016/j.taap.2015.12.002

10.4049/jimmunol.180.8.5689

10.1016/j.atherosclerosis.2011.07.020

10.1126/science.1140488

10.1038/ki.2015.148

10.3389/fimmu.2014.00578

10.1007/978-1-4939-6563-2_1

10.1093/nar/gkq1305

10.1136/ard.2008.100289

10.1101/pdb.prot5421

10.1038/nm.2054

10.3233/CBM-140431

10.1073/pnas.0605298103

10.1042/CS20100003

10.1002/path.4874

10.1084/jem.20141898

10.1002/wrna.121

10.1016/j.mehy.2011.11.019

10.1016/j.jconrel.2015.08.011

10.1161/01.CIR.98.2.100

10.1126/scisignal.2004497

10.1007/s00059-016-4495-4

10.1016/j.mrfmmm.2014.01.001

10.1038/ki.2012.241

10.1016/j.ccr.2006.01.025

10.1038/nrg3763

10.4161/epi.26931

10.1016/j.jconrel.2013.09.015

10.5966/sctm.2015-0355

10.1155/2011/247654